David A. Hill, MD, PhD

Excited to attend the #AAAAI26 foundation benefit tonight. What an important event that is central to supporting so many advances in allergy and immunology!

Go see Hill Lab member Natasha Puzon‘s #AAAAI26 poster presentation on how #diet influences #asthma right now!

Go see Hill Lab member Julie Dilollo‘s #AAAAI26 poster presentation on #EoE T cells right now!

Come see past Hill Lab member and current CHOP A/I Assistant Professor Stan Gabryszewski give his talk on Artificial Intelligence in EoE at the CEGIR/TiGERS session right now! #AAAAI26

Come see Hill Lab member Julie give her oral abstract at the CEGIR/TiGERS session right now!

What would your vote be?

Congratulations to all of the #AAAAI26 Foundation awardees!

Very excited for the first day of #AAAAI26! Welcome to Philadelphia!

What if dietary fat acts as an immune signal?

In our new review, we explore how saturated fatty acids activate conserved inflammatory pathways, shape immune cell function, and may represent an evolutionarily conserved host defense mechanism. Look for it soon in DNA and Cell Biology!

🎉 Excited to share that our newest manuscript has been accepted in @insight.jci.org!

We identify CD9 as a key regulator of macrophage-driven adipose remodeling, linking immune–stromal crosstalk to metabolic dysfunction in obesity!

Stay tuned!

#obesity #immunometabolism #macrophages #adiposetissue

Big thanks to our funders: #FoodAllergyFund, @aaaaiorg.bsky.social, @apfed.bsky.social, @chopresearch.bsky.social, and others!

2026 is off to a great start...🚨New publication alert!🚨

Our latest paper is out in Diagnostics!

🧬 We show that functional T-cell blood tests accurately predict milk and soy allergy in EoE, an important step towards a clinical test!

🔗 Read the full paper here: www.mdpi.com/2075-4418/16...

Had a great time at the #GordonFoodAllergy conference last week! What a wonderful community of highly dedicated investigators!

The CHOP Allergy and Immunology Division has a new recent publications board! Look at all that new knowledge… but the best is yet to come!

BIG thanks to our funders: The Food Allergy Fund, @aaaaiorg.bsky.social, @apfed.bsky.social, The Hartwell Foundation, and others!

Excited to share our latest work, soon to be published in Diagnostics!

This trial of >200 patients showed high performance for the #EoE #Food #Test! This transformational technology is now under development by the CHOP Clinical Immunology Lab.

Stay tuned to know when the paper drops!

Oesophageal Epithelial Cell‐Intrinsic MHCII Regulates Food Antigen‐Dependent Eosinophilic Esophagitis in an IFNγ‐Dependent Manner We found that oesophageal epithelial cells upregulate MHCII expression during active EoE in humans and a mouse model. MHCII expression by EECs was governed by IFNγ-inducible transcriptional elements....

Just in time for the holidays...🚨New publication alert!🚨

Our latest paper is out in Clinical and Experimental Allergy!

The esophagus is not just for food transport! Esophageal epithelial cells help to control allergic inflammation via expression of MHCII!

onlinelibrary.wiley.com/doi/10.1111/...

Seven feel-good science stories to restore your faith in 2025 Immense progress in gene editing, drug discovery and conservation are just some of the reasons to be cheerful about 2025.

www.nature.com/articles/d41...

The Nuremberg Code and Its Lasting Relevance to Allergy and Immunology - PubMed The Nuremberg Code and Its Lasting Relevance to Allergy and Immunology

Check out this new editorial from CHOP attending Tim Buckley!

pubmed.ncbi.nlm.nih.gov/41423097/

Excited to share our latest work, soon to be published in Clinical & Experimental Allergy!

We uncover a protective role for #IFN-γ–induced epithelial MHCII in limiting eosinophilic inflammation in #EoE!

Big thanks to the funders including @aaaaiorg.bsky.social!

Stay tuned to know when it drops!

Feeding kids with food allergies can be expensive. So CHOP opened a pantry to help families access allergen-free staples Households that struggle to pay for items like egg substitute and soy milk can find them at the health system's Buerger Center. And a delivery program is in the works.

Way to go, @childrensphila.bsky.social Allergy and Immunology!

nam10.safelinks.protection.outlook.com?url=https%3A...

Peanut Allergy Prevention: What we have learned from early introduction (Episode 206) Podcast Episode · Primary Care Perspectives · 12/09/2025 · 30m

Check out @chopresearch.bsky.social Allergy/Immunology Dr. Stan Gabryszewski speaking on Katie Lockwood’s Primary Care Perspectives Podcast about our latest peanut allergy study!

podcasts.apple.com/us/podcast/p...

It’s paper submission (and resubmission) day!

I really enjoyed speaking with Stephanie on Public Health On Call. Please help to get the word out that early allergen introduction is safe and effective!

I really enjoyed this conversation, and I hope others find it helpful!

Thanks for a great visit, UAB and Children’s of Alabama! Such a phenomenal group doing inspiring work.

Allergen-specific mRNA-lipid nanoparticle therapy for prevention and treatment of experimental allergy in mice - PubMed Allergic diseases have reached epidemic proportions globally, calling attention to the need for better treatment and preventive approaches. Herein, we developed allergen-encoding messenger RNA (mRNA)-lipid nanoparticle (LNP) strategies for both therapy and prevention of allergic responses. Immunizat …

Cool new technology that holds promise for asthma and other antigen-driven allergic conditions!

pubmed.ncbi.nlm.nih.gov/40985871/

Single cell RNA-seq analysis of hematopoietic cell types in 22q11.2 deletion syndrome reveals significant changes to non-T cells - PubMed Surprisingly, all cell types examined exhibited differences between patients and controls. Monocytes and NK cells, the cell types least likely to be directly impacted by thymic effects, had unique patterns of gene expression, although both were highly altered in patients. This suggests a widespread …

Check out this great new article by @katesullimmuno.bsky.social !

pubmed.ncbi.nlm.nih.gov/41174964/

CHOP study finds peanut allergies declined in kids after updated guidance There was a 43% decline in peanut allergies among U.S. children under 3 after the release of new early introduction guidelines.

www.inquirer.com/health/peanu...

Thanks Philadelphia Inquirer!

And now! A link! slate.com/podcasts/wha...