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Dave Natale

@drcnatale.bsky.social

Associate professor - Queen’s University Placenta researcher studying trophoblast stem cells and fetal growth restriction using cell culture and rodent models of placental pathology Views are my own

100 Followers  |  155 Following  |  7 Posts  |  Joined: 10.02.2025
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Posts by Dave Natale (@drcnatale.bsky.social)

Thrilled to see this work published!
Congratulations Jessie, Bry and Dan!

07.11.2025 05:29 — 👍 4    🔁 0    💬 0    📌 0

Excited to share the latest work from our lab investigating human placental pericytes!

22.10.2025 15:04 — 👍 4    🔁 1    💬 0    📌 0
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Exploring the differentiation potential of EomesPOS mouse trophoblast cells in mid-gestation Mouse trophoblast stem (mTS) cells can be derived from the blastocyst or extraembryonic ectoderm as late as embryonic day (E) 6.5 and when cultured in…

Full paper link: tinyurl.com/vcp23d95

06.10.2025 11:43 — 👍 3    🔁 2    💬 1    📌 0
Immunofluorescence Staining of E17.5 Ai6 x Eomes-Cre Placentae for Mesenchymal Cells. EomesPOS cells and daughters (ZsGreen; green), all counterstained with NucBlue (DAPI; blue). (A) Staining of endothelial cells in the chorion and lower labyrinth layer with an anti-CD31 antibody (red; 400x). Ai6NEG (above) and Ai6POS (below). (B) Staining of placental pericytes in the labyrinth layer with an anti-αSMA antibody (red; 400x). Ai6NEG (above) and Ai6POS (below). White arrowheads show colocalization of ZsGreen with antibody staining.

Immunofluorescence Staining of E17.5 Ai6 x Eomes-Cre Placentae for Mesenchymal Cells. EomesPOS cells and daughters (ZsGreen; green), all counterstained with NucBlue (DAPI; blue). (A) Staining of endothelial cells in the chorion and lower labyrinth layer with an anti-CD31 antibody (red; 400x). Ai6NEG (above) and Ai6POS (below). (B) Staining of placental pericytes in the labyrinth layer with an anti-αSMA antibody (red; 400x). Ai6NEG (above) and Ai6POS (below). White arrowheads show colocalization of ZsGreen with antibody staining.

#DBfeature

Lineage tracing of Eomes-positive mouse trophoblast cells confirms their capacity to contribute to both placental layers in vivo even after E7.5

-Avery McGinnis, Megan Cull, Nichole Peterson, Matthew Tang, Bryony Natale @bnatale.bsky.social, David Natale

#Extraembryonic

06.10.2025 11:43 — 👍 6    🔁 4    💬 1    📌 0
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Identifying established human placental markers of schizophrenia in rodents after gestational ∆9-tetrahydrocannabinol exposure† Summary Sentence Prenatal THC exposure led to alterations in the expression of established prioritized markers of schizophrenia in placenta and brain model

Excited to see my MSc student Andrea Kocsis’ BOR publication identifying THC-specific placental markers of #schizophrenia academic.oup.com/biolreprod/a... #cannabis #placenta @drcnatale.bsky.social @schulichmeddent.bsky.social @sriwomenshealth.bsky.social @placentadoc.bsky.social

12.09.2025 10:41 — 👍 6    🔁 2    💬 0    📌 0
Assistant or Associate Professor and Canada Research Chair, Tier 2, Biology or Health Sciences or Neuroscience (Human Metabolic Disease) - Office of the Deputy Provost (Academic Operations and Plannin... About the Position The Faculty of Science invites applications for a Canadian Institute of Health Research (CIHR) Tier 2 Canada Research Chair (CRC) appointment in Biology, as applicable to Human Meta...

🔊Share widely!
Were looking for a Tier 2 CRC in Human Metabolic Disease!

Just posted but hurry as app deadline is May 15!

Got expertise in #obesity or #diabetes and are an emerging expert in your field?

Apply now!!!!

carleton.ca/deputyprovos...

08.04.2025 22:44 — 👍 10    🔁 29    💬 1    📌 1

Thanks @westernu.bsky.social for your continued support of our research!

08.04.2025 14:05 — 👍 4    🔁 1    💬 0    📌 0
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Omega-3s have potential to counteract THC effects on fetal development, study finds Previous studies show exposure to Tetrahydrocannabinol (THC)—the main psychoactive component in cannabis—while in utero can lead to lower birth weight and potential heart complications in newborn anim...

Omega-3s have potential to counteract THC effects on fetal development

"The best way to prevent the adverse cardiac health outcomes in offspring is to stop using cannabis, but this study raises the exciting possibility that an Omega-3 diet could be beneficial to those…exposed to cannabis in utero."

04.04.2025 14:57 — 👍 10    🔁 4    💬 1    📌 0
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Congratulations Matthew, Caelan, Daniel, Sophia on your spectacular posters! What a way to finish up your fourth year projects!

Congrats as well to all the students who presented over the past three days - wonderful job and amazing studies!
@queensuglobal.bsky.social

04.04.2025 15:34 — 👍 5    🔁 1    💬 0    📌 0
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A huge thank you to everyone who joined us at the 2025 SRI Annual Scientific Meeting!

With over 1,000 attendees from more than 30 countries, this year’s meeting was an incredible success.

📸 Keep an eye out for the SRI 2025 photo album coming soon!

#SRI2025

01.04.2025 20:00 — 👍 11    🔁 3    💬 0    📌 0
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#SRI2025 poster award!!
Congratulations Caelan!!

29.03.2025 21:26 — 👍 4    🔁 0    💬 0    📌 0
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Congratulations Caelan on your spectacular poster presentation at SRI in Charlotte, NC today!!! Amazing job and an awesome meeting!
@queensuglobal.bsky.social @sriwomenshealth.bsky.social

29.03.2025 01:49 — 👍 9    🔁 2    💬 1    📌 0

Great session today!
Thank you @sriwomenshealth.bsky.social for the opportunity to present our work!!

28.03.2025 03:08 — 👍 2    🔁 0    💬 0    📌 0
Assistant Professor (Tenure-Track) | Department of Medical Genetics | Life Sciences Institute (LSI) - Department of Medical Genetics The Department of Medical Genetics, in collaboration with the Life Sciences Institute (LSI), invites applications for a full-time faculty position at the rank of Assistant Professor, tenure track with...

My alma mater, the University of British Columbia, Dept of Medical Genetics, is hiring for a tenure track junior faculty position specializing in chromatin regulation / gene regulatory mechanisms. Beautiful city and vibrant epigenetics research. Please share!

medgen.med.ubc.ca/assistant-pr...

04.03.2025 02:36 — 👍 171    🔁 107    💬 3    📌 4
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Excited to share the latest work from our lab - published in @devbiol.bsky.social!

can01.safelinks.protection.outlook.com?url=https%3A...

Congratulations Avery, @bnatale.bsky.social , Matthew Tang, Megan Cull and Nicki Peterson!

18.02.2025 22:16 — 👍 9    🔁 4    💬 0    📌 0
Preview
Exploring the differentiation potential of EomesPOS mouse trophoblast cells in mid-gestation Mouse trophoblast stem (mTS) cells can be derived from the blastocyst or extraembryonic ectoderm as late as embryonic day (E) 6.5 and when cultured in…

Exploring the differentiation potential of EomesPOS mouse trophoblast cells in mid-gestation
#trophoblaststemcells #lineagetracing

Congratulations McGinnis et al, @drcnatale.bsky.social

www.sciencedirect.com/science/arti...

17.02.2025 16:21 — 👍 5    🔁 2    💬 0    📌 0