Priya Prakash pryprk - Bluesky Statics

Cellular mechanisms of brain lipid metabolism in health and disease - Nature Cell Biology This Review discusses brain lipid metabolism from a cellular perspective, focusing on lipid uptake, de novo synthesis, storage, breakdown and intercellular transfer, and highlights its emerging implic...

Cellular mechanisms of brain lipid metabolism in health and disease www.nature.com/articles/s41...

20.02.2026 15:45 — 👍 0 🔁 0 💬 0 📌 0

Sleep-dependent clearance of brain lipids by peripheral blood cells - Nature Peripheral macrophage-like haemocytes in Drosophila promote sleep by clearing lipid buildup in the brain, helping to maintain metabolic homeostasis and brain function and fitness.

Sleep-dependent clearance of brain lipids by peripheral blood cells www.nature.com/articles/s41...

18.02.2026 14:57 — 👍 1 🔁 1 💬 0 📌 0

Spatially resolved transcriptome–metabolome integration reveals region-specific glial lipid dysregulation associated with Alzheimer’s pathology Glial cells maintain the brain’s lipid and energy balance, and their breakdown is increasingly recognized as a causal contributor to Alzheimer’s disease (AD). While this concept is established, no approach has directly shown how glial homeostatic failure manifests across brain regions and microenvironments or how it links local pathology, such as plaques, to global metabolic imbalance. To address this gap, we developed iMIST, an integrated platform that combines MALDI-based metabolite imaging, histology, and spatial transcriptomics within a single tissue section to align molecular and anatomical information. Using a mouse model of late-onset AD that recapitulates both amyloid deposition and metabolic vulnerability, iMIST revealed that glial lipid dysregulation is widespread but spatially specialized. In gray matter, plaque-associated microglia were associated with upregulated glycerophospholipid-remodeling in cortico-thalamic areas indicating metabolic stress around local pathology. In contrast, white matter tracts rich in lipid-producing oligodendrocytes show plaque-independent deficits in galactosylceramide metabolism reflecting their high myelin demand. Both processes intensify with age, transforming adaptive glial responses into persistent metabolic dysfunction. Together, these findings demonstrate the spatial interplay between global glial metabolic imbalance and local microenvironmental stressors associated with AD pathology. By integrating transcriptomic and metabolomic information in situ , iMIST provides a framework for uncovering how regional glial vulnerability shapes the pathogenesis of neurodegenerative diseases. ### Competing Interest Statement The authors have declared no competing interest. NIH, R01NS130876, R01AI178795, R01AI149699, R42GM143989, P01AG002132, R01AG082141

Spatially resolved transcriptome–metabolome integration reveals region-specific glial lipid dysregulation associated with Alzheimer’s pathology www.biorxiv.org/content/10.6...

30.01.2026 18:01 — 👍 0 🔁 0 💬 0 📌 0

Dying oligodendrocytes persist without mitochondria www.biorxiv.org/content/10.6...

23.01.2026 18:52 — 👍 4 🔁 0 💬 0 📌 0

Myelin is repaired by constitutive differentiation of oligodendrocyte progenitors Oligodendrocytes form myelin sheaths around axons to enable rapid signaling within neural circuits. The generation of new oligodendrocytes through differentiation of oligodendrocyte precursor cells (O...

Myelin is repaired by constitutive differentiation of oligodendrocyte progenitors www.science.org/doi/10.1126/...

23.01.2026 00:24 — 👍 3 🔁 2 💬 0 📌 0

Inducible deletion of DGAT1 and 2 from microglia exacerbates neurodegeneration and endolysosomal lipid accumulation in male PS19 mice Brain myeloid cells accumulate neutral lipids in multiple human neurodegenerative disorders and relevant mouse models. These lipids are often assumed …

Inducible deletion of DGAT1 and 2 from microglia exacerbates neurodegeneration and endolysosomal lipid accumulation in male PS19 mice www.sciencedirect.com/science/arti...

20.01.2026 13:44 — 👍 6 🔁 2 💬 0 📌 0

Single-cell RNA sequencing uncovers molecular features underlying microglial lipid accumulation and depression-related behaviors in high-fat diet mouse model of obesity | Neuropsychopharmacology Obesity is a worldwide health crisis, with unhealthy diet as a major contributor. Comorbid neuropsychiatric conditions such as depression and anxiety are associated with obesity. Since obesity is a pro-inflammatory state, chronic neuroinflammation may mediate obesity and neuropsychiatric comorbidity. We used RNA-seq to provide a single-cell resolution transcriptome of brain immune cells using long-term high-fat diet (HFD) to model obesity in male mice. HFD mice exhibited depression and anxiety-like behavior. We observed a shift towards increased proportions of lipid droplet-accumulating microglia (LDAM) in the long-term HFD brain. By in-depth characterization of the transcriptional signature of LDAM, we identified that ACSL1, a key regulator of lipid droplet biogenesis, was highly expressed in LDAM induced by HFD. Finally, we demonstrated that ACSL1 inhibition reduced lipid droplets deposition in microglia exposed to free fatty acids (FFA). Our findings provide a comprehensive view of the molecular changes in brain immune cells associated with HFD, suggesting a link between microglial lipid droplet accumulation and neurological comorbidities induced by obesity.

Here, long-term high-fat diet in ♂️🐭 induced anxiety- & depression-like behavior + ⬆️ lipid droplet–accumulating microglia, linking microglial lipid storage to neuroinflammation, which may underlie obesity-related psychiatric comorbidities

09.01.2026 17:30 — 👍 1 🔁 1 💬 0 📌 0

Neuronal fatty acid oxidation fuels memory after intensive learning in Drosophila - Nature Metabolism Neurons are shown to use fatty acid β-oxidation as a fuel source for memory formation upon intensive learning in Drosophila, challenging the view that neurons are unable to use fatty acids for energy ...

Textbooks said neurons don’t burn fatty acids for energy🤔. Our study delivers the first in vivo demonstration that fatty acid oxidation in defined memory neurons fuels memory formation.

Closing chapter of my PhD 🥳, out today in Nature Metabolism💥 @natmetabolism.nature.com

10.12.2025 11:13 — 👍 105 🔁 26 💬 4 📌 2

Postdoc Portrait: Priya Prakash This postdoc uncovers how glial dysfunction drives neurodegeneration in a rare movement disorder.

I was featured on The Scientist as a part of their 'Postdoc Portraits' series where I spoke about my scientific career path and ongoing work on oligodendrocyte dysfunction in neurodegeneration. Check it out! www.the-scientist.com/postdoc-port...

01.12.2025 18:56 — 👍 32 🔁 7 💬 0 📌 1

PREPRINTS ON THEIR WORK:

Priya - www.biorxiv.org/content/10.1... and www.biorxiv.org/content/10.1... (press - www.npr.org/2024/10/07/n...)

Melissa - www.biorxiv.org/content/10.1... (press - www.thetransmitter.org/astrocytes/a...)

18.11.2025 20:58 — 👍 2 🔁 1 💬 0 📌 0

#SfN #SocietyForGlia
STARTING NOW!

Ending strong with the last www.liddelowlab.com presentations of the week.

@pryprk.bsky.social
talking about a world first mouse model for XDP... and OLIGODENDROCYTES!

@melcooperphd.bsky.social
presenting on astrocyte networks in the mouse forebrain.

18.11.2025 20:58 — 👍 11 🔁 4 💬 1 📌 0

IT'S A BUSY AFTERNOON FOR THE LAB!

@mrodea.bsky.social - astrocyte chromatin in reactive astrocytes across the forebrain

Nick Kathman - COCKROACH BRAIN ALERT! (is this the largest single cell atlas of an insect brain?)

@liddelowsa.bsky.social - multiomic approaches to study astrocyte reacitivity

17.11.2025 20:38 — 👍 7 🔁 1 💬 0 📌 0

Congrats to our very own Ipshita Zutshi on being awarded the Peter & Patricia Gruber International Research Award in Neuroscience!! #SfN25

16.11.2025 23:42 — 👍 7 🔁 1 💬 0 📌 0

Advances in the genetics and pathology of Lewy body dementia Lewy body dementia is a heterogeneous disease that is underdiagnosed and poorly understood. Pathologically, Lewy body dementia is characterised by the…

Very happy to have contributed to this new review on Lewy body dementia in @thelancetneuro.bsky.social led by Sonja W. Scholz. We highlight the latest advances in genetics and pathology. @liddelowsa.bsky.social Check it out! www.sciencedirect.com/science/arti...

13.11.2025 00:56 — 👍 14 🔁 5 💬 0 📌 0

Looking forward to presenting our work on oligodendrocyte dysfunction in a rare neurodegenerative movement disorder X-linked Dystonia Parkinsonism. Come say hi if you're around on Tuesday, Nov 18 between 1-5 pm! @sfn.org #SfN2025 #SfN25

10.11.2025 23:09 — 👍 13 🔁 3 💬 0 📌 0

(1/2)
preprints:

@melcooperphd.bsky.social - astrocyte networks pubmed.ncbi.nlm.nih.gov/40777296/

@mrodea.bsky.social - single cell analysis & diversity www.biorxiv.org/content/10.1...

@pryprk.bsky.social - XDP www.biorxiv.org/content/10.1..., www.biorxiv.org/content/10.1...

See you in San Diego

10.11.2025 16:43 — 👍 5 🔁 2 💬 1 📌 0

@sfn.org #SfN25 #SanDiego starts this Saturday. The lab is going to be there in full force - see our presentations below.
Represented this year by @borderbiologist.bsky.social, Nick Kathman, @mrodea.bsky.social, @melcooperphd.bsky.social, @pryprk.bsky.social, @kerrylimberg.bsky.social.

(1/2)

10.11.2025 16:43 — 👍 50 🔁 17 💬 1 📌 4

Hepatic acetyl-CoA metabolism modulates neuroinflammation and depression susceptibility via acetate Cao et al. show that hepatic hydrolysis of acetyl-CoA by acyl-CoA thioesterase 12 serves as a crucial source of circulating acetate mediating liver-brain communication, which signals the brain to buff...

Liver-brain axis in neuroinflammation. Hepatic acetyl-CoA metabolism modulates neuroinflammation and depression susceptibility via acetate. www.cell.com/cell-metabol...

07.11.2025 13:47 — 👍 2 🔁 0 💬 0 📌 0

Spatial dynamics of brain development and neuroinflammation - Nature A tri-omic atlas of the mouse brain from postnatal day 0 to P21 reveals that layer-specific projection neurons have a role in coordinating axonogenesis and myelination.

Our latest collaboration with @rongfan8.bsky.social, spatial triomics to investigate myelin and cortical brain development, and demyelination, spearheaded by Leslie Kirby in our lab @ki.se and Di Zhang in Rong's lab! Check it out @nature.com

www.nature.com/articles/s41...

05.11.2025 16:03 — 👍 78 🔁 26 💬 5 📌 2

Cholesterol metabolic reprogramming mediates microglia-induced chronic neuroinflammation and hinders neurorestoration following stroke - Nature Metabolism Persistent microglial activation upon ischaemic injury leads to the formation of stroke-associated foamy microglia, perpetuating long-term inflammation, white matter damage and functional impairments....

Cholesterol metabolic reprogramming mediates microglia-induced chronic neuroinflammation and hinders neurorestoration following stroke www.nature.com/articles/s42...

05.11.2025 11:00 — 👍 2 🔁 0 💬 0 📌 0

Heartbreaking, well crafted thread from an immigrant scientist who’s decided being in the US isn’t worth the struggle anymore.

31.10.2025 13:36 — 👍 1 🔁 1 💬 0 📌 0

After 13 years in the US, I’ve made the difficult decision to leave. Having packed up everything and rethought about priorities, rather painstakingly, while I’m sad to leave the life I’ve made here, I’m also relieved that I won’t have to plan my life around immigration policies anymore.

31.10.2025 04:08 — 👍 786 🔁 158 💬 18 📌 34

Oligodendroglial fatty acid metabolism as a central nervous system energy reserve - Nature Neuroscience Brain functions require a constant supply of glucose. However, the brain energy stores are unclear. Here, the authors show that oligodendroglial fatty acid metabolism can be an energy reserve for whit...

Oligodendroglial fatty acid metabolism as a central nervous system energy reserve www.nature.com/articles/s41...

01.11.2025 01:29 — 👍 4 🔁 0 💬 0 📌 0

We're thrilled to publish 2 exciting preprints today on the molecular pathology of X-linked Dystonia Parkinsonism!
biorxiv.org/content/10.1...
AND
biorxiv.org/content/10.1...

@nyulangone.bsky.social

08.10.2025 17:53 — 👍 6 🔁 1 💬 1 📌 1

We've been doing some amazing stuff outside the astrocyte realm.
Check out our latest Oligo investigation led by @pryprk.bsky.social !

24.10.2025 16:40 — 👍 19 🔁 3 💬 0 📌 0

🌏 We thank all the amazing clinicians, geneticists, and neuroscientists across continents who contributed to these two studies to better understand and treat this rare disorder.

24.10.2025 16:32 — 👍 2 🔁 0 💬 0 📌 0

This work was primarily funded by the Collaborative Center for XDP (CCXDP) and NHGRI’s Center of Excellence in Genomic Science – The Center for Synthetic Regulatory Genomics at NYU Langone Health.

24.10.2025 16:32 — 👍 2 🔁 0 💬 1 📌 0

This work represents a close collaboration between the @liddelowsa.bsky.social 🫶 @jefboeke.bsky.social labs at NYU Grossman School of Medicine as a part of The Dark Matter Project @darkmatterproject.bsky.social.

24.10.2025 16:32 — 👍 1 🔁 0 💬 1 📌 0

a computer generated image of a dna molecule with a t on it ALT: a computer generated image of a dna molecule with a t on it

🧬 Dive into the complex genetics of the XDP mice in our companion paper led by Weimin Zhang, Yu (Jeremy) Zhao, Ran Brosh, Jef Boeke, and team:

'Genome writing to dissect consequences of SVA retrotransposon disease X-Linked Dystonia Parkinsonism'
www.biorxiv.org/content/10.1...

24.10.2025 16:32 — 👍 2 🔁 1 💬 1 📌 0

a colorful brain on a black background with a galaxy in the middle ALT: a colorful brain on a black background with a galaxy in the middle

These findings expand the view beyond neurons, revealing glial contributions to XDP and the broader role of retrotransposons in shaping brain health and disease.

🧠 Read the whole story:
'Myelin pathology is a key feature of X-linked Dystonia Parkinsonism' www.biorxiv.org/content/10.1...

24.10.2025 16:32 — 👍 1 🔁 0 💬 1 📌 0

Posts by Priya Prakash (@pryprk.bsky.social)