Priya Prakash

PICALM Alzheimer’s risk allele causes aberrant lipid droplets in microglia www-nature-com.ezproxy.med.nyu.edu/articles/s41...

Huntington's disease successfully treated for first time www.bbc.com/news/article...

Mitochondrial transfer www.nature.com/articles/s42...

Happy to share that I have been awarded an @alzassociation.bsky.social grant to advance our work on astrocyte lipids in tau-mediated neurodegeneration. Important gaps remain in understanding glial lipid metabolism in AD and related diseases, and I’m excited to drive this work forward! #ALZFunded

Out today in @nature.com: Together with the Honigmann, Shevchenko, Drobot and Hof labs, we present a general workflow for imaging the localization and transport of individual lipids in cells and mapping their metabolism.
www.nature.com/articles/s41...

Postdoc paper submitted! Venturing into a completely new research direction with incredible collaborators and a fascinating finding. Excited to see how it all pans out! 🚀

Amyloid-β induces lipid droplet-mediated microglial dysfunction via the enzyme DGAT2 in Alzheimer’s disease Why microglia stop reducing amyloid deposits from Alzheimer’s disease (AD) brains is unknown. Prakash, Manchanda, et al. show that microglia increase their lipid droplets and lose their phagocytic cap...

Dysregulated lipid metabolism in Alzheimer’s disease causes lipid buildup in microglia, reducing the immune cell’s ability to clear amyloid beta plaques.

Original article: www.cell.com/immunity/ful...

Amyloid Beta Impairs Microglia Function in Alzheimer’s Disease Dysregulated lipid metabolism in Alzheimer’s disease causes lipid buildup in microglia, reducing the immune cell’s ability to clear amyloid beta plaques.

'Amyloid Beta Impairs Microglia Function in Alzheimer’s Disease' the-scientist.com/amyloid-beta... Our work on microglial lipid droplets in Alzheimer's disease featured on The Scientist by Shelby Bradford.

Of course!

We worked with Emma from Draw Impacts for our cover art submission for Immunity. bsky.app/profile/pryp...

Glia-derived noncanonical fatty acid binding protein modulates brain lipid storage and clearance Glial lipid chaperone Obp44a maintains brain health by regulating lipid transport, waste clearance, and stress responses.

Glia-derived noncanonical fatty acid binding protein modulates brain lipid storage and clearance www.science.org/doi/10.1126/... Fly glia secrete Obp44a, a fatty acid binding protein, that binds long-chain fatty acids and shuttles between glia and neurons.

a sign that says do not enter hangs above a woman ALT: a sign that says do not enter hangs above a woman

Haha watch out!

Sadaf! I somehow missed this update. Congratulations! 🎉What a fantastic news! 🙌

If I have to read one more 'single cell atlas' paper... 😑

Brain myelin as a deficient energy source in aging and disease Central nervous system (CNS) myelin may act as a dynamic energy store that supports brain metabolism; its consumption and replenishment is a newly recognized form of metabolic plasticity aimed at main...

Brain myelin as a deficient energy source in aging and disease www.cell.com/trends/endoc... Excellent discussion on how myelin fatty acid reserves may be reallocated during aging and neurodegeneration

Lipid metabolism and neuroinflammation: What is the link? rupress.org/jem/article/... Another nice review covering lipid metabolism in the CNS, including discussion of interferon pathways and their connection to lipid regulation

Triglycerides are an important fuel reserve for synapse function in the brain - Nature Metabolism Kumar et al. show that under glucose-depleted conditions, neurons can use fatty acids as an alternative source of energy to support synaptic function.

Triglycerides are an important fuel reserve for synapse function in the brain www.nature.com/articles/s42...

thank you! :)

Immune cells’ fat blocks brain’s ability to clean Alzheimer’s plaques Alzheimer's disease progression linked to microglia fat metabolism, potential new treatment target identified in recent study.

Excited to share @thehindu.com coverage of our research: “Immune cells’ fat blocks brain’s ability to clean Alzheimer’s plaques” -- now out in print and online! Grateful to Manjeera Gowravaram for the thoughtful and clear storytelling. www.thehindu.com/sci-tech/sci...

Thank you so much for your kind words!

thank you! the kool-aid is the DGAT2 degrader (i.e., that reduces lipid droplets in microglia so they can get rid of the amyloid) :)

How this image is #notthecover? It's the coolest one I've seen in a while! All praise to M, our microglia savior, for destroying amyloid and rescuing neurons!

Thank you, Danielle! @cp-immunity.bsky.social

tiny but significant* details 😅

Thanks so much, Kelsey! I'm a superman fan and wanted to make a microglia superwoman 😅 We also tossed around a Star Wars–themed cover idea but the superwoman ultimately won! 🦸‍♀️ @davalos.bsky.social came up with the idea of DGAT2 kool-aid, lipid droplet shackles, and all the tiny details! 🙌

Amyloid-β induces lipid droplet-mediated microglial dysfunction via the enzyme DGAT2 in Alzheimer’s disease Why microglia stop reducing amyloid deposits from Alzheimer’s disease (AD) brains is unknown. Prakash, Manchanda, et al. show that microglia increase their lipid droplets and lose their phagocytic cap...

Bummed we didn’t get the cover, but absolutely thrilled that Emma Videl (drawimpacts) brought our microglia superhero vision to life in the most fantastic way! 🦸‍♀️🧠💥

#SciArt #Alzheimers #Microglia #Immunity‍ #notthecover

www.cell.com/immunity/ful...

Meet M, our microglia superheroine 🦸‍♀️💥

After chugging the magical DGAT2-Stop! Kool-Aid 💊🧃, she breaks free from her lipid droplet shackles 💥💪

Supercharged, she lifts the amyloid beams 🧱 trapping neurons and saves the city of Brain 🧠🏙️!

Our cover submission for @cp-immunity.bsky.social. #notthecover

#notthecover, but it’s beautiful and captures the science so well! Thank you for sharing your creative vision with us!

Very cool, thanks for sharing!

Thanks Shane! 🙏🏽