 
                        
                Trials of the Firstborn
                It's not easy being the first kid in a family, but at least you get to inoculate your sibs.
            
        
    
    
            Firstborns donβt have the luxury of a tested microbiota, typically passed down via sibling snot, to tutor their naΓ―ve immune system. That lack of education leads firstborns to overreact when exposed to new microbes.
scottcanderson.substack.com/p/trials-of-...
               
            
            
                14.10.2025 02:48 β π 1    π 0    π¬ 0    π 0                      
            
         
            
        
            
        
            
            
            
            
            
    
    
            
                             
                        
                Life Can Start Out Crappy
                Birth is full of microbes. Thatβs how nature planned it.
            
        
    
    
            Your amniotic bubble having popped, you become exposed to the world. Itβs your big day and everything is cold, dry and infectious. You, of course, are naked. You have no real consciousness yet, and you won't remember this day, but you know enough to cry.
scottcanderson.substack.com/p/birth-is-p...
               
            
            
                21.09.2025 14:36 β π 4    π 0    π¬ 0    π 0                      
            
         
            
        
            
            
            
            
            
    
    
            
                             
                        
                Embryos Are Living In a Microbial World
                Embryos are full of potential, but very vulnerable. And microbes play a surprising role.
            
        
    
    
            The idea that beneficial bacteria could be passed down by mothers is shocking to many doctors and scientists, who think that microbes associated with embryos are universally pathogenic. Yet researchers keep finding microbes wherever they look.
scottcanderson.substack.com/p/embryos-ar...
               
            
            
                15.09.2025 12:59 β π 3    π 0    π¬ 0    π 0                      
            
         
            
        
            
            
            
            
            
    
    
            
                             
                        
                A Bed Fit for an Egg
                As an embryo develops, microbes play a mysterious role.
            
        
    
    
            There is a connection between maternal depression and preterm birth. Surprisingly, even paternal depression can contribute to the preterm risk. However, there are hints that psychobiotic treatment can help minimize this effect.
scottcanderson.substack.com/p/a-bed-fit-...
               
            
            
                05.09.2025 15:14 β π 2    π 0    π¬ 0    π 0                      
            
         
            
        
            
            
            
            
            
    
    
            
                             
                        
                Boy Meets Girl
                From an awkward and inauspicious meeting of two cells, a miracle happens.
            
        
    
    
            Reproductive biology is pretty perfunctory when it comes to the male contribution. In many animals, the male is actually optional. If one isn't around, the mother can execute the whole business on her own in a process called parthenogenesis.
scottcanderson.substack.com/p/boy-meets-...
               
            
            
                29.08.2025 15:58 β π 3    π 1    π¬ 0    π 0                      
            
         
            
        
            
            
            
            
            
    
    
            
                             
                        
                Epigenetics and Development
                If your genes represent the blueprint, epigenetics represent the construction crew.
            
        
    
    
            Studies by John Cryan and Ted Dinan have demonstrated that beneficial microbe can cause epigenetic effects in the brain, favoring the growth of new nerve cells and enhancing cognition. Amazing science!
scottcanderson.substack.com/p/epigenetic...
               
            
            
                22.08.2025 20:36 β π 2    π 1    π¬ 0    π 0                      
            
         
            
        
            
        
            
            
            
            
            
    
    
            
                             
                        
                Pregnant Moms Need Pampering
                Pregnant mothers, like all of us, are stressed by modern life. This can have a long-term impact on their kids. Here are some tips for mitigating the stress.
            
        
    
    
            Pregnant women who are stressed can suffer from an impaired microbiome. That can be passed down to their babies, affecting their weight, mood, and attitude, often into their teens or later.
www.psychologytoday.com/us/blog/mood...
               
            
            
                29.07.2025 16:00 β π 2    π 0    π¬ 0    π 0                      
            
         
            
        
            
            
            
            
            
    
    
            
                             
                        
                Can Gut Microbes Improve Postpartum Depression?
                Emerging research suggests that a bacteria found in yogurt could improve maternal mood.
            
        
    
    
            Can a microbe help with postpartum depression? Learn more about a bacterium that improves gut health, soothes the immune system, reduces cortisol and boosts oxytocin. 
scottcanderson.substack.com/p/can-gut-mi...
               
            
            
                25.07.2025 17:08 β π 3    π 0    π¬ 0    π 0                      
            
         
            
        
            
            
            
            
            
    
    
            
                             
                        
                OCD and the Gut-Brain Axis
                Could Your Gut Flora Be Fueling OCD?
            
        
    
    
            The gut-brain axis explains the astonishing connections between the microbes that live in your gut and your brain issues, including OCD. When your gut microbes are out of balance, your mood may suffer, and your OCD may worsen.
scottcanderson.substack.com/p/ocd-and-th...
               
            
            
                18.07.2025 18:44 β π 3    π 0    π¬ 0    π 0                      
            
         
            
        
            
            
            
            
            
    
    
            
                             
                        
                Can Gut Microbes Improve Postpartum Depression?
                A common microbe, found in yogurt, could improve mothers' moods after birth, research suggestsβpotentially helping ward off postpartum depression.
            
        
    
    
            Stressed moms have higher levels of cortisol, but also lower levels of oxytocin, the βcuddle hormone.β This one-two punch affects rat moms so deeply that they stop licking their pups. In that way, moms transfer stress to their pups.
www.psychologytoday.com/us/blog/mood...
               
            
            
                07.07.2025 20:14 β π 4    π 0    π¬ 1    π 0                      
            
         
            
        
            
            
            
            
            
    
    
            
                             
                        
                Autism, Inflammation, and the Gut-Brain Axis
                Inflammation may play a surprising role in autistic behavior.
            
        
    
    
            Is there is a microbial fingerprint of autism? By analyzing oral microbes, researchers can predict whether or not a child will develop autism with 80 percent accuracy. 
scottcanderson.substack.com/p/autism-inf...
               
            
            
                05.07.2025 13:45 β π 4    π 0    π¬ 0    π 0                      
            
         
            
        
            
        
            
        
            
            
            
            
            
    
    
            
                             
                        
                Is Your Gut Sabotaging Your Meds? Part 1
                The state of your gut has a surprising impact on your medsβand vice versa.
            
        
    
    
            Variations in gut microbiome composition may influence drug metabolism, potentially explaining why some patients respond better to treatment than others. It may not be sufficient to test drugs without considering the microbiome.
scottcanderson.substack.com/p/is-your-gu...
               
            
            
                20.06.2025 14:30 β π 2    π 0    π¬ 0    π 0                      
            
         
            
        
            
            
            
            
            
    
    
            
                             
                        
                Stress Eating and the Microbiome
                Can you treat eating disorders with a microbiome-friendly diet?
            
        
    
    
            Iβve been stress eating since the election. It turns out that gut microbes play a major role in stress eating. Thatβs actually great, because we have some control over our microbiome. Ready for some cool science?
scottcanderson.substack.com/p/stress-eat...
               
            
            
                18.06.2025 02:04 β π 3    π 0    π¬ 0    π 0                      
            
         
            
        
            
            
            
            
            
    
    
            
                             
                        
                Stress Eating and the Microbiome
                Can you treat eating disorders with a microbiome-friendly diet?
            
        
    
    
            Gut microbes play a major role in stress eating. Thatβs great because we have some control over our microbiome. Want to learn more?
scottcanderson.substack.com/p/stress-eat...
               
            
            
                13.06.2025 16:14 β π 0    π 0    π¬ 0    π 0                      
            
         
            
        
            
            
            
            
            
    
    
            
                             
                        
                We Are Jailing Scientists Now
                Scientist Kseniya Petrova has spent 3 months in a detention center in Louisiana. Itβs about to get worse.
            
        
    
    
            Itβs June 6, and Harvard scientist Kseniya Petrova is still in detention in Louisiana. This is a gift from Trump to Putin and a blow to Harvard and Alzheimerβs research. How can you help?
scottcanderson.substack.com/p/we-are-jai...
               
            
            
                06.06.2025 15:07 β π 2    π 0    π¬ 0    π 0                      
            
         
            
        
            
            
            
            
            
    
    
            
                             
                        
                What Juicing Does to Your Brain
                Is it time to retire your juicer?
            
        
    
    
            Juicing is a health-food staple, but what is it doing to the gut-brain axis?
scottcanderson.substack.com/p/what-juici...
               
            
            
                06.06.2025 13:24 β π 2    π 0    π¬ 0    π 0                      
            
         
            
        
            
            
            
            
            
    
    
            
                             
                        
                4 Scary Food Additives
                Why you don't keep carboxymethylcellulose in your kitchen.
            
        
    
    
            Food additives may not have a big effect on human biology, but some of them kill beneficial bacteria in the gut. Hereβs what to look out for:
scottcanderson.substack.com/p/4-scary-fo...
               
            
            
                03.06.2025 00:43 β π 2    π 0    π¬ 0    π 0                      
            
         
            
        
            
            
            
            
            
    
    
            
                             
                        
                What Trump is Doing to Your Colon
                Presidential chaos creates anxiety that can affect your gut microbiome.
            
        
    
    
            Trump affects your gut-brain axis by stressing you with his flip-flopping. Here are some hacks to help.
scottcanderson.substack.com/p/what-trump...
               
            
            
                01.06.2025 17:52 β π 2    π 0    π¬ 0    π 0                      
            
         
            
        
            
            
            
            
            
    
    
            
                             
                        
                We Are Jailing Scientists Now
                Scientist Kseniya Petrova has spent 3 months in a detention center in Louisiana. Itβs about to get worse.
            
        
    
    
            Itβs May 31, and Harvard scientist Kseniya Petrova is still in detention in Louisiana. This is a gift from Trump to Putin and a blow to Harvard and Alzheimerβs research. A total outrage. Here are some tips to help.
scottcanderson.substack.com/p/we-are-jai...
               
            
            
                31.05.2025 16:14 β π 2    π 0    π¬ 0    π 0                      
            
         
            
        
            
            
            
            
            
    
    
            
                             
                        
                What Trump is Doing to Your Colon
                Presidential chaos creates anxiety that can affect your gut microbiome.
            
        
    
    
            As Trump changes his mind on an hourly basis, flinging America around like a dog with a chew toy, we are subject to uncertainty and loss of control. This is a sure path to anxiety and gut issues. 
scottcanderson.substack.com/p/what-trump...
               
            
            
                31.05.2025 14:53 β π 2    π 0    π¬ 0    π 0                      
            
         
            
        
            
            
            
            
            
    
    
            
                             
                        
                We Are Jailing Scientists Now
                Scientist Kseniya Petrova has spent 3 months in a detention center in Louisiana. Itβs about to get worse.
            
        
    
    
            Her Harvard supervisor says Petrova is "spectacular, the best I've ever seen in 20 years at Harvard." Without her, the research has been put on hold. What a victory for the Trump administration.
scottcanderson.substack.com/p/we-are-jai...
               
            
            
                30.05.2025 21:29 β π 1    π 0    π¬ 0    π 0                      
            
         
            
        
            
            
            
            
            
    
    
            
                             
                        
                What Trump is Doing to Your Colon
                Presidential chaos creates anxiety that can affect your gut microbiome.
            
        
    
    
            As Trump changes his mind on an hourly basis, flinging America around like a dog with a chew toy, we are subject to uncertainty and loss of control. This is a sure path to anxiety and gut issues. 
scottcanderson.substack.com/p/what-trump...
               
            
            
                30.05.2025 15:13 β π 1    π 0    π¬ 0    π 0                      
            
         
            
        
            
            
            
            
            
    
    
            
                             
                        
                Addiction and the Gut-Brain Axis
                Addiction can be fostered and exacerbated by a poor gut microbiota.
            
        
    
    
            Addiction has a connection to your gut microbes. This weird association is both intriguing and liberating.
scottcanderson.substack.com/p/addiction-...
               
            
            
                30.05.2025 01:55 β π 3    π 0    π¬ 0    π 0                      
            
         
            
        
            
            
            
            
            
    
    
    
    
            bsky.app/profile/psyc...
Early life stress can leave deep scars, but a good microbiome can improve resilience.
www.psychologytoday.com/us/blog/mood...
               
            
            
                28.05.2025 18:15 β π 4    π 0    π¬ 0    π 0                      
            
         
            
        
            
            
            
            
            
    
    
            
                             
                        
                A Microbial Signature of Dementia
                Gut microbes are significantly different in people with cognitive impairments.
            
        
    
    
            People with fewer and less-diverse gut microbes are more likely to have cognitive impairment, including dementia and Alzheimerβs. 
scottcanderson.substack.com/p/a-microbia...
               
            
            
                28.05.2025 18:08 β π 2    π 0    π¬ 0    π 0                      
            
         
    
         
        
            
        
                            
                    
                    
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