Ben Ereshefsky, PharmD

I also try to emphasize how much fluid and sodium you get with IV antibiotics. Every so often it works, but usually I’m just ignored 🤷🏻‍♂️.

Really disappointed in the ATS’ stubbornness and doubling down on a bad rec that they keep trying to justify with weak reasoning.

Effectiveness of Doxycycline in Combination with Other Antibiotics for Gram-Positive Periprosthetic Joint Infections: a Causal Inference Study AbstractObjectives. Doxycycline is occasionally used as step-down therapy in periprosthetic joint infections (PJI), but evidence supporting its efficacy is

New PJI study in @ofidjournal.bsky.social:

Largest restrospective study to date of doxycycline use for PJI treatment with encouraging results

All doxycycline use was in combination though, primarily rifampin. Limited to Staph, Coryne, & Cuti

#IDSky #OrthoID

academic.oup.com/ofid/advance...

“When the rich wage war, it’s the poor who die.”
-Sartre

🥳SIDP is turning 35 this year!🥳 Let’s get in that celebratory birthday mood by looking back at some of the things going on when SIDP was founded 😱⏰ Follow along because we’ll be keeping the party going all year long!

Don’t worry, he’ll come down with some new injury come playoff time (just not before he gets the OKC out of lottery contention though)!

Pathogenesis of Mucormycosis, Host Defenses, and Potential Future Therapeutic Targets. Mucorales sporangiospores released into the air from sporangia are inhaled, and the sporangiospore coat protein CotH3 binds to GRP78 on the pseudostratified columnar epithelial cells of the upper resp tract, where the sporangiospores may germinate into hyphae to invade nasal airways and sinuses (Panel A). Sporangiospores, by means of another coat adhesin (CotH7), also bind to epidermal growth factor receptor (EGFR) and integrin α3β1 receptor on pulmonary alveolar epithelial cells of the lower respiratory tract, which triggers a downstream transcriptional response involving cytokines (interleukin-6 and interleukin-8), chemokines (CCL2 and CCL5), and intercellular adhesion molecule 1 (ICAM-1). Hyphal invasion also triggers production of hypoxia-inducible factor 1α (HIF1α) and release of proinflammatory cytokines. In wound-related mucormycosis, traumatic inoculation of fungal elements (found on the surfaces of rocks, wood, glass, and metal) into damaged tissue allows for the development of infection in a host with immune paralysis due to trauma. The release of endogenous host-derived molecules known as damage-associated molecular patterns (DAMPs) reduces phagocytosis, impairs chemotaxis, and induces immune paralysis. Mucoricin released by the invading hyphae induces death of immune and endothelial cells, which results in tissue necrosis and accelerates endovascular thrombosis, ischemia, and infarction (Panel B). PMNs and monocytes recognize early germinated sporangiospores by pattern recognition receptors (e.g., TLR2) that detect mucorales-associated molecular patterns (e.g., 1,3-βD-glucans exposed on hyphal structures). Intrinsic host colony-stimulating factors such as granulocyte–macrophage colony-stimulating factor (GM-CSF) and IFN-γ further contribute to augmentation of innate host defenses against the invading hyphae, which in turn dampen immune responses. Factors in the tissue …

Risk factors for Mucormycosis

Risk factors for mucormycosis continued

Mucormycosis

Review in @nejm.org by Dimitrios Kontoyiannis and Tom Walsh

www.nejm.org/doi/10.1056/...

#IDSky #TxID #MedMycoSky @msgerc.bsky.social

FDA declines to review Moderna's mRNA flu shot Under Health Secretary Robert F. Kennedy Jr., the Food and Drug Administration has taken an aggressive stance against mRNA technology.

I genuinely cannot believe the degree to which we are pissing away this generational breakthrough, even given the fuckmuppets who are involved www.nbcnews.com/health/healt...

Gulag Americana

Today's front page on @lemonde.fr

DHS has shot 12 people during immigration enforcement operations since September:

This speaks volumes about the problems we face where the ID experts aren’t respected! #IDSky

ACIP Chair Says Polio Vaccine Should be Optional | Contagion Live Kirk Milhoan, MD, PhD, said vaccine choice is the most important element to the public even with the possibility of people contracting this disease or others when given the right to opt out of vaccina...

🧵 Why even suggesting that polio vaccination should be optional is dangerous.
www.contagionlive.com/view/acip-ch...

If it looks like a Nazi and sounds like a Nazi…

I don’t know how else to tell you that your life literally doesn’t matter to these people, and they do not want to make America healthy

Google the video & see for yourself.

This is not law enforcement. This is murder.

Sickening.

2. I also blame “sepsis.” Too often people just call something sepsis, and never think about the the of infection they’re treating, the organisms that cause that infection, and actual risk factors or prevalence of MDRO.

1. These are some great points! There are definitely too many ways to take shortcuts (somewhat understandable given how there’re really not any incentives to take more time to think through a problem).

Effectiveness and Impact of Maternal RSV Immunization and Nirsevimab in US Children This study estimates maternal respiratory syncytial virus (RSV) vaccine and nirsevimab effectiveness against acute respiratory illness and estimates the impact of these products on RSV-associated hosp...

Getting the #RSV #vaccine during pregnancy helped protect babies under 6 months:
• Cut doctor visits for RSV by about two-thirds
• Reduced RSV hospitalizations by about 70%

jamanetwork.com/journals/jam...

Waiting 4 days seem excessively long to wait for de-escalation!

Biggest takeaway is that we have got to find a way to improve #MedEd so that anti-MRSA and anti-pseudomonal ABX are NOT the preferred empiric treatments for community-acquired infections.

#IDSky

This is a wildly unethical study that would be illegal to conduct in the United States. Have you heard of the Tuskegee experiments (crimes against humanity)? This sounds like that.

More reasons for me never to go to Florida again!

I hope @sidpharm.bsky.social can get the annual meeting moved to a pro-vaccine state soon.

Impact of institutional treatment guidance on the management and outcomes of Stenotrophomonas maltophilia and carbapenem-resistant Acinetobacter baumannii infections | Antimicrobial Stewardship & Healthcare Epidemiology | Cambridge Core Impact of institutional treatment guidance on the management and outcomes of Stenotrophomonas maltophilia and carbapenem-resistant Acinetobacter baumannii infections - Volume 5 Issue 1

@ryanvpharmd.bsky.social @brainofbpharm.bsky.social: This study evaluated the impact of a guidance document on treatment decisions, clinical outcomes for CRAB, Steno. Our results demonstrate that implementing a treatment guideline may ⬆️ guideline directed treatment. doi.org/10.1017/ash....

White House Begins Christmas Season With Ceremonial Lighting Of Cross

White House Begins Christmas Season With Ceremonial Lighting Of Cross

The ACIP decision to discontinue the recommendation for a universal hepatitis B birth dose vaccine will cause harm.

As the federal government continues to fail children's health, families can rely on our nation's physicians to continue to put children's health first.

Any death is tragic; however, the Food and Drug Administration’s vague declaration about the COVID-19 vaccine and pediatric deaths undermines confidence in the safety of the vaccine and raises questions about FDA’s own approval process.

Our statement: bit.ly/44B8IvH

I hate to say it, but absolutely do NOT listen to the CDC about vaccines. #IDSky #VaccineSky

Decades of rigorous and scientifically sound research have proven that vaccines do not cause autism. CDC’s decision to change language on its website reversing that finding is reckless & harmful.

Our statement w/ @hivma.bsky.social, APIC, @sheaepi.bsky.social & @sidpharm.bsky.social: bit.ly/3XEc0KH

The corrupted CDC website refers to a Danish study (Andersson et al) and "a statistically significant 67% increased risk of Asperger's syndrome per 1 mg increase in aluminum exposure among children born between 2007 and 2018 (Supplement Figure 4)." It's worth putting this into context. Short 🧵

A screen shot of the antibiotic personality quiz

It’s World AMR Awareness Week, and this year I had the honor to re-imagine and doodle the antibiotics in the antibiotic personality quiz 😇🖍️
Thank u @brxad.bsky.social for this amazing and fun opportunity!

C’mon, take the quiz, it’s a #WAAW tradition 😉💊
#IDSky

quiz.tryinteract.com#/59e68e3a8ec...