Iva Pashkuleva

Bioinspired helical systems with defined chirality assembled from discrete peptide and glycan amphiphiles Molecular helices are ubiquitous in biological systems and play key roles in life functions such as recognition, coding and transferring information, replication, catalytic activity, among others. They can have different handedness and dimensions from molecular to macroscale but the exact mechanisms for their forma

Don't miss this #OpenAccess review by Vânia I. B. Castro, Rui L. Reis, Ricardo A. Pires and Iva Pashkuleva

"Bioinspired helical systems with defined chirality assembled from discrete peptide and glycan amphiphiles"

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Bioinspired helical systems with defined chirality assembled from discrete peptide and glycan amphiphiles Molecular helices are ubiquitous in biological systems and play key roles in life functions such as recognition, coding and transferring information, replication, catalytic activity, among others. The...

doi.org/10.1039/D5CS...

Fresh off the press: Life uses homochiral D-sugars and L-amino acids to code information but how chiral information is transferred to different structural levels
doi.org/10.1039/D5CS... Vania Castro, Rui L. Reis, @ricardoapires.bsky.social.Thanks to the reviewers and the editors @chemsocrev.rsc.org

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Thanks, Joao!

Nanoengineered Self-Assembling Peptides with Increased Proteolytic Stability Promote Wound Healing The copper complex of the tripeptide glycine–histidine–lysine (GHK) has proven benefits in wound healing and tissue remodeling by promoting blood vessel growth and increasing skin oxygen levels, but i...

How to hide a functional peptide from an enzyme without to compromise its bioactivity? Here👇👇👇 is our suggestion #self-assembly
doi.org/10.1021/acsa...
@pubs.acs.org

1st MOBILIsE Symposium in Molecular Bioengineering
📅16-18 June 2025
📍i3S

📝Abstract submission until 12Mar
⏰Early registrations also until 12Mar
➕info: tinyurl.com/2s4hu9ad
#i3Sevents #ERAChairs #EUfunding #MOBILIsE

Effect of Hyaluronan Molecular Weight on the Stability and Biofunctionality of Microfibers Assembled by Interfacial Polyelectrolyte Complexation Nervous system disorders are characterized by a progressive loss of function and structure of neurons that ultimately leads to a decline in cognitive and motor functions. In this study, we used interfacial polyelectrolyte complexation (IPC) to produce fibers for neural tissue regeneration. IPC is a processing method that allows spinning of sensitive biopolymers. The rate of spinning and the properties of the used biopolymers (charge and molecular weight) influence different characteristics of the fibers such as size and stability, among others. We used two major components of the neuronal stem cell niche, the polycationic collagen (Col) and the polyanionic hyaluronic acid (HA), to obtain bioactive fibers. We tested HA with different molecular weights and found that HA with medium and high molecular weights (350 and 1200 kDa, respectively) enabled drawing of microfibers with a homogeneous distribution of Col and HA, whereas low-molecular-weight HA (40 kDa) did not allow spinning. The obtained microfibers showed high swelling ability in a physiological buffer: their diameters increased more than 5-fold from their dry state. At these conditions, the tensile storage moduli of the fibers were similar to nervous tissues. Collagenase and hyaluronidase did not change the morphology of the fibers for up to 3 days but reduced their moduli 2- to 3-fold. Assays with PC12 neuronal-like cells showed that IPC microfibers support cell adhesion and viability regardless of the molecular weight of the used HA.

Happy to share our work on interfacial polyelectrolyte complexation of hyaluronan and collagen. We obtained microfibers from extracellular matrix components using only supramolecular interactions - no high temperatures, no crosslinking. doi.org/10.1021/acsa... #Chemsky @acspublications.bsky.social

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