Grateful to my mentors @jshendure.bsky.social, @coletrapnell.bsky.social, @cbmoens.bsky.social, @wnoble.bsky.social, Bob Waterston, @ksusztak.bsky.social , and Qinghua Cui for their guidance and support along the way 🙏 !!

04.11.2025 15:10 — 👍 1    🔁 0    💬 0    📌 0

Thrilled to share I’ve started my lab at Dartmouth’s Geisel School of Medicine! We focus on mapping cellular trajectories & TF networks in development and Mendelian disorders, exploring new therapies. Join us—postdocs, grads, and scientists welcome! sites.dartmouth.edu/qiulab/

04.11.2025 15:10 — 👍 16    🔁 10    💬 2    📌 0

New paper from my lab and @jshendure.bsky.social lab! Led by the brilliant @zukailiu.bsky.social and @cxqiu.bsky.social. We tackled how anterior and posterior progenitor cells cooperate to self-organize into an embryonic structure (termed AP-gastruloid). (1/n) www.biorxiv.org/content/10.1...

26.09.2025 18:06 — 👍 54    🔁 20    💬 3    📌 2

Lineage recording in monoclonal gastruloids reveals heritable modes of early development Mammalian stem cells possess a remarkable capacity for self-organization, a property that underlies increasingly sophisticated in vitro models of early development. However, even under carefully contr...

New preprint with the Shendure lab @jshendure.bsky.social ! We apply the DNA Typewriter lineage recorder to mouse 3D gastruloids, a powerful model of early mammalian development. Led by Sam Regalado and CX Qiu @cxqiu.bsky.social : www.biorxiv.org/content/10.1... (1/13)

27.05.2025 14:56 — 👍 49    🔁 13    💬 2    📌 0

Lineage recording in monoclonal gastruloids reveals heritable modes of early development Mammalian stem cells possess a remarkable capacity for self-organization, a property that underlies increasingly sophisticated in vitro models of early development. However, even under carefully contr...

Big thanks to Sam Regalado, @‪cxqiu.bsky.social‬, @jshendure.bsky.social and all co-authors for sharing this journey. Also check out the accompanying preprint applying barcoded monoclonals for lineage recording with @choijunhong.bsky.social. www.biorxiv.org/content/10.1...

25.05.2025 11:00 — 👍 6    🔁 1    💬 0    📌 0

Barcoded monoclonal embryoids are a potential solution to confounding bottlenecks in mosaic organoid screens Genetic screens in organoids hold tremendous promise for accelerating discoveries at the intersection of genomics and developmental biology. Embryoid bodies (EBs) are self-organizing multicellular str...

Expanding Perturb-seq-like screens to multicellular systems also increases the complexity of confounding effects. We encountered this when we perturbed all TFs in mosaic embryoid bodies (EBs) and develop a scalable solution by barcoding monoclonal individuals. 🧵 www.biorxiv.org/content/10.1...

25.05.2025 11:00 — 👍 63    🔁 14    💬 1    📌 2