Natalie Wong

The amoeba Naegleria gruberi has two distinct cell states with different structures, including a mitotic spindle (left) and flagella (right). These cells use different tubulins to build these different structures. CREDIT: Andrew Kennard (University of Massachusetts, Amherst).

By investigating the peculiar states of the #amoeba Naegleria gruberi, researchers showed that #microtubules are more than just simple building blocks of the #cytoskeleton. In PNAS Journal Club: www.pnas.org/post/journal...

#tubulin #CellBiology #evolution

Cancer cells restrict immunogenicity of retrotransposon expression via distinct mechanisms Overexpression of transposable elements is a common feature of cancer. Sun, You, et al. show that, in pancreatic ductal adenocarcinoma, tumor cells adapt through different mechanisms to mitigate a spe...

A new study in @cellpress.bsky.social Immunity from the lab of Dr. Benjamin Greenbaum provides insights into how #PancreaticCancer cells accommodate active retrotransposons without triggering the innate immune response. #oncsky #medsky

Microscopic images of the cerebral cortex and hippocampus in brains with Alzheimer's disease.

Dr. Gabor Kovacs’ team at UHN's Krembil Brain Institute has characterized the diversity in the neuropathological changes responsible for #Alzheimers, including a novel subtype, paving the way for personalized care.

Read more ➡️ www.uhnresearch.ca/news/unlocki...

AI: The New Virtual Radiologist 🩻 🫁

Researchers at UHN’s Toronto General Hospital Research Institute are using AI to enhance the accuracy and consistency of organ evaluation for lung #transplantation.

Read more ➡️ www.uhnresearch.ca/news/ai-new-...

IRE1α silences dsRNA to prevent taxane-induced pyroptosis in triple-negative breast cancer Mechanisms dictating the form of chemotherapy-induced cancer cell death are elusive. This study reports that immunologically cold triple-negative breast cancer (TNBC) hijacks an ancient ER stress resp...

Blocking IRE1α enables RNA accumulation, triggering ZBP1-driven cell death and making cold TNBC tumors ICI-sensitive!

www.cell.com/cell/fulltex...

Insurance, legal, and financial hardships of childhood and adolescent cancer survivors—a systematic review - Journal of Cancer Survivorship Purpose Childhood and adolescent cancer survivors (CACS) experience medical and psychosocial adverse effects. Attention widens to include issues such as socio-bureaucratic hardships. This systematic r...

A number of #AYA cancer survivors experience insurance and financial hardships, including foregoing medical care due to financial constraints, problems paying medical bills, and difficulties accessing loans or insurances. #survonc #ayacsm

link.springer.com/article/10.1...

🧪Participants who received a single dose had a 78% lower risk of symptomatic COVID-19 infection in the first month compared to placebo. That compares quite favorably with the efficacy of approved COVID vaccines, which has been reported to be 52% at four weeks.
apnews.com/press-releas...

A must-have food for Thanksgiving 🦃🍴

Share a little cutie. 🐶🐶

Vascular #GeneEditing therapy #MultisystemiSmoothMuscleDysfunctionSyndrome

ABE8e-eVRQR
AAV-PR
MYH11-Cre:ACTA2 R179H/+🐭
P3 iv▶️
8-wk editing
Liver 45%🫀12%🧠vessel 7% Aorta 1%

Lifespan 6➡️23 wk
⬇️Aorticφ
⬆️Locomotor
⬆️🧠Arteriolar SMC

@markelindsay.bsky.social bioRxiv 2024
www.biorxiv.org/content/10.1...

Hello! I'm Jane and I make nature inspired art using printmaking and mixed media processes including cyanotype, linocut and collage. I would describe myself as a left wing nature lover with plenty of woke thrown in! Would love to connect with like-minded folks on this platform 😊

Single-cell RNA sequencing (scRNA-seq) is an important tool for analyzing the cellular composition and heterogeneity of organoids. Through scRNA-seq, researchers can accurately identify various cell types in neural organoids, including neural progenitor cells (NPCs), neurons, and glial cells.

I am a new user of Bluesky. I look forward to meeting industry elites in the same industry through this platform and having more exchanges and learning with everyone. 🤝