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Steven Kleinstein

@skleinstein.bsky.social

Computational immunologist; Professor at Yale School of Medicine; Co-Director, Computational Biology & Biomedical Informatics; B cell receptor sequencing analysis, http://immcantation.org + multi-omics signatures of infection, vaccination & autoimmunity.

1,239 Followers  |  492 Following  |  8 Posts  |  Joined: 19.11.2024
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Posts by Steven Kleinstein (@skleinstein.bsky.social)

AIRR Community Meeting VIII.

πŸš€ Registration is now OPEN for AIRR Community Meeting VIII: Decoding and Recoding Immunity! Join us June 8–11, 2026 at Yale University (USA) or attend virtually. πŸ’Έ Early-bird rates available until April 15! πŸ”— Register: tinyurl.com/airrcmeeting8

#AIRRC8 #immunosky

27.02.2026 20:28 β€” πŸ‘ 5    πŸ” 5    πŸ’¬ 1    πŸ“Œ 2
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Immcantation.org user or interested in #Bcell & #Tcell repertoire analysis? #AIRRseq

🚨Register now for the "2026 Immcantation Users Group Meeting"

πŸ—“οΈFREE virtual meeting on January 22, 2026 from 10AM – 1:30PM ET.

πŸ”—Program & registration: immcantation.github.io/users-meetin...

07.01.2026 14:42 β€” πŸ‘ 6    πŸ” 5    πŸ’¬ 0    πŸ“Œ 0
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Immcantation.org user or interested in #Bcell & #Tcell repertoire analysis? #AIRRseq

🚨Register now for the "2026 Immcantation Users Group Meeting"

πŸ—“οΈFREE virtual meeting on January 22, 2026 from 10AM – 1:30PM ET.

πŸ”—Program & registration: immcantation.github.io/users-meetin...

07.01.2026 14:42 β€” πŸ‘ 6    πŸ” 5    πŸ’¬ 0    πŸ“Œ 0
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Interested in pursuing a PhD in Computational Biology and Biomedical Informatics (CBB) at Yale?

Join us for a CBB PhD Virtual Open House
Tuesday, November 11 | 8:00–9:00 PM ET

πŸ‘‰ Register here: yalesurvey.ca1.qualtrics.com/jfe/form/SV_...

@yalecbb.bsky.social

31.10.2025 22:43 β€” πŸ‘ 4    πŸ” 1    πŸ’¬ 0    πŸ“Œ 0
SPE - join us Postdoctoral position: In January 2026, we are relocating to Yale university to start a theory initiative at the Center for Systems and Engineering Immunology (CSEI). We are looking for talented postd...

excited to announce that this January we are relocating to Yale to start a theory initiative at the Center for Systems and Engineering Immunology (CSEI): @yalecsei.bsky.social

looking to hire 2 postdocs to join us in this endeavor.

more details can be found here: sites.google.com/uw.edu/statp...

27.10.2025 20:47 β€” πŸ‘ 18    πŸ” 8    πŸ’¬ 1    πŸ“Œ 0
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Interested in pursuing a PhD in Computational Biology and Biomedical Informatics (CBB) at Yale?

Join us for the CBB PhD Virtual Open House
Tuesday, October 21 | 8:00–9:00 PM ET

πŸ‘‰ Register here: yalesurvey.ca1.qualtrics.com/jfe/form/SV_...

@yalecbb.bsky.social

16.10.2025 01:26 β€” πŸ‘ 3    πŸ” 1    πŸ’¬ 0    πŸ“Œ 0

TODAY is the deadline for abstract submission for the 2026 Immcantation Users Group Meeting!

immcantation.github.io/users-meetin...

01.10.2025 13:12 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
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🚨 Immcantation.org user or interested in #Bcell repertoire analysis?
πŸ—“οΈ Join the FREE virtual 2026 Immcantation Users Group Meeting
πŸ“… Jan 22, 2026 | ⏰ 10AM–1:30PM ET
πŸ“’ Abstracts due Oct 1, 2025
πŸ”— immcantation.github.io/users-meeting/2026

#AIRRseq #Immcantation

24.09.2025 10:46 β€” πŸ‘ 3    πŸ” 2    πŸ’¬ 0    πŸ“Œ 1
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🚨 One week left! 🚨 Don’t forget to submit your 250-word abstract by October 1st! Share how you use Immcantation and contribute to building a supportive, collaborative research community. πŸ”— 2026 Immcantation Users Group Meeting immcantation.github.io/users-meeting/2026 #airrseq #immunosky

24.09.2025 07:57 β€” πŸ‘ 3    πŸ” 3    πŸ’¬ 0    πŸ“Œ 0
2026 Immcantation Users Group Meeting. Important information summary:
Who: open to the public
When: January 22nd, 2026
Time: 10:00 am - 1:30 pm ET
Where: Virtual
Fee: Free
Abstracts due: October 1st, 2025
Final program: December 1st, 2025

2026 Immcantation Users Group Meeting. Important information summary: Who: open to the public When: January 22nd, 2026 Time: 10:00 am - 1:30 pm ET Where: Virtual Fee: Free Abstracts due: October 1st, 2025 Final program: December 1st, 2025

🚨 Immcantation.org user or interested in #Bcell repertoire analysis?
πŸ—“οΈ Join the FREE virtual 2026 Immcantation Users Group Meeting
πŸ“… Jan 22, 2026 | ⏰ 10AM–1:30PM ET
πŸ“’ Abstracts due Oct 1, 2025
πŸ”— immcantation.github.io/users-meeting/2026

#AIRRseq #Immcantation

28.08.2025 13:38 β€” πŸ‘ 6    πŸ” 5    πŸ’¬ 0    πŸ“Œ 1
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Atul Butte died yesterday. | Euan Ashley Atul Butte died yesterday. The world lost a giant. A big bear of a man. With a huge smile. With love for everyone. With energy that could power a room. I loved everything about Atul. I loved how he wa...

Our condolences to family and friends of our long collaborator Atul Butte. Word of his death came from Euan Ashley of @stanfordmedicine.bsky.social
#memorial
www.linkedin.com/posts/euanas...

14.06.2025 23:01 β€” πŸ‘ 5    πŸ” 1    πŸ’¬ 0    πŸ“Œ 0
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Mapping of human monoclonal antibody responses to XBB.1.5 COVID-19 monovalent vaccines: a B cell analysis Our findings offer key molecular insights into whether strain-specific boosters elicit sufficient protection against SARS-CoV-2 emerging variants. This knowledge can inform decisions on booster design...

Our collaborators @camilahcoelho.bsky.social @vivianasimonlab.bsky.social (+ others)
show that monovalent XBB.1.5 vaccines recall mostly cross-reactive antibodies to ancestral SARS-CoV-2, not robust de novo responses.
@lancetmicrobe.bsky.social
#ImmuneSky
www.thelancet.com/journals/lan...

02.06.2025 15:48 β€” πŸ‘ 5    πŸ” 6    πŸ’¬ 0    πŸ“Œ 0
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Next week, we are hosting an international scientific workshop focused on the pathogenesis of #LongCovid at
@yalemed.bsky.social.

Please join us on May 15th to learn about what we know and what we need to investigate next to get to the root causes to accelerate therapies πŸ‘‡πŸΌπŸ‘‡πŸΌ

10.05.2025 20:18 β€” πŸ‘ 183    πŸ” 66    πŸ’¬ 8    πŸ“Œ 1
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Don’t forget! 🌺πŸ§ͺ Our HIPC symposium is happening tomorrow β€” join us for a great lineup of talks from
@bjoernpeters.bsky.social, @lungdrc.bsky.social, @settelab.bsky.social, Victoria Zyulina & Thomas Hagan
Tues May 6th | 8:30-10:30 am | Room 313C #Immunology #AAI2025 #HIPC

05.05.2025 23:36 β€” πŸ‘ 6    πŸ” 3    πŸ’¬ 0    πŸ“Œ 0
Chart shows numbers of studies in data resource for Human Immunology Project consortium. more details at immunespace.org

Chart shows numbers of studies in data resource for Human Immunology Project consortium. more details at immunespace.org

Come get our #immune data, free #FAIRsharing is at @immportdb.bsky.social
- from @columbiauniversity.bsky.social
@icahn.bsky.social
@yalemedicine.bsky.social
@stanfordimmunology.bsky.social
@benaroyaresearch.bsky.social
@lji.org
MIT, Seattle Children's
#AAI2025
#ImmuneSky #IDsky

23.04.2025 17:01 β€” πŸ‘ 5    πŸ” 4    πŸ’¬ 0    πŸ“Œ 0
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Teaching machines the language of biology: Scaling large language models for next-generation single-cell analysis

What if LLMs could β€œread” & β€œwrite” biology? πŸ€”
Introducing C2S‑Scaleβ€”a Yale and Google collab: we scaled LLMs (up to 27B!) to analyze & generate single‑cell data 🧬 ➑️ πŸ“
πŸ”— Blog: research.google/blog/teachin...
πŸ”— Preprint: biorxiv.org/content/10.1...

18.04.2025 14:13 β€” πŸ‘ 18    πŸ” 10    πŸ’¬ 2    πŸ“Œ 0

Below, from earlier today, confirmed @statnews.com www.statnews.com/2025/04/18/n...

18.04.2025 21:42 β€” πŸ‘ 219    πŸ” 97    πŸ’¬ 13    πŸ“Œ 2
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Guest Symposia - IMMUNOLOGY2025β„’ Information and details about Guest Symposia to be presented at IMMUNOLOGY2025β„’!

Exciting news!! We are happy to announce that we will have a HIPC Symposium at @aai.org on Tues, May 6th. HIPC will also have a Super Booth at #AAI2025 along with @iedb.bsky.social
and the iAKC Project. Check out the full Symposia list, and see you there! πŸ”—: immunology2025.aai.org/guest-sympos...

03.04.2025 22:07 β€” πŸ‘ 6    πŸ” 5    πŸ’¬ 0    πŸ“Œ 1
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Great to have our latest review "The cellular factors that impair the germinal center in advanced age" out @jimmunol.bsky.social.

Work led by @wsfoster.bsky.social and Edith Marcial-JuΓ‘rez. With @sanmarti92.bsky.social creating the beautiful GC images in figure 2.

doi.org/10.1093/jimm...

17.03.2025 21:42 β€” πŸ‘ 37    πŸ” 11    πŸ’¬ 0    πŸ“Œ 2
Map of Stand Up for Science events, with official SUFS events in Red and solidarity events in Blue

Map of Stand Up for Science events, with official SUFS events in Red and solidarity events in Blue

WHERE WILL YOU BE ON MARCH 7TH!?

Head to www.standupforscience2025.org/local-event-information/ or the link in our bio to find your closest eventβ€”or add one if you're hosting one!

#standupforscience2025

02.03.2025 02:04 β€” πŸ‘ 2259    πŸ” 1160    πŸ’¬ 77    πŸ“Œ 173

πŸš¨β˜€οΈ Hey Bluesky! Know anyone near the following cities that would be willing to help us Stand Up for Science? β˜€οΈπŸš¨

Annapolis, MD
Bismarck, ND
Boise, ID
Charleston, WV
Dover, DE
Jackson, MS
Anchorage or Juneau, AK
Montpelier, VT
Richmond, VA

Send them our way!

#standupforscience2025

21.02.2025 21:15 β€” πŸ‘ 413    πŸ” 213    πŸ’¬ 25    πŸ“Œ 14
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Welcome to the Bluesky account for Stand Up for Science 2025!

Keep an eye on this space for updates, event information, and ways to get involved. We can't wait to see everyone #standupforscience2025 on March 7th, both in DC and locations nationwide!

#scienceforall #sciencenotsilence

12.02.2025 17:04 β€” πŸ‘ 11494    πŸ” 5432    πŸ’¬ 291    πŸ“Œ 670
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β€˜I really wanted something to happen.’ The students behind the Stand Up for Science protests New group hopes to turn out researchers for 7 March demonstrations against Trump administration policies

Scientists are now organizing events, called Stand Up for Science, on 7 March in Washington, D.C., and state capitals.

So far, they have attracted more than 100 volunteers from some 30 states who are hoping to rally support for research as a public good. scim.ag/4328LAD

19.02.2025 16:54 β€” πŸ‘ 725    πŸ” 360    πŸ’¬ 2    πŸ“Œ 24
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2025 Immcantation Users Group Meeting - YouTube The 2025 Immcantation Users Group Meeting (https://immcantation.github.io/users-meeting/2025/index.html) took place on January 30th, 2025. It served as a vir...

Presentations from the 2025 Immcantation Users Group Meeting are now available on the Immcantation YouTube channel! Thank you to our speakers and participants! www.youtube.com/playlist?lis... #immcantation #airrseq #immunosky

19.02.2025 16:36 β€” πŸ‘ 2    πŸ” 1    πŸ’¬ 0    πŸ“Œ 0
Identification of a multi-omics factor predictive of long COVID in the IMPACC study Following SARS-CoV-2 infection, ∼10-35% of COVID-19 patients experience long COVID (LC), in which often debilitating symptoms persist for at least three months. Elucidating the biologic underpinnings ...

Our collaborators identify multi-omic factor that predicts #LongCovid
Among 50+ authors include @sesmalab.bsky.social @joanndarce.bsky.social @bjoernpeters.bsky.social
@slimfourati.bsky.social @droferlevy.bsky.social @leying2024.bsky.social
#IDsky #MedSky
www.biorxiv.org/content/10.1...

19.02.2025 17:14 β€” πŸ‘ 5    πŸ” 2    πŸ’¬ 1    πŸ“Œ 0
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tagtango: an application to compare single-cell annotations AbstractSummary. In this article, we present tagtango, an innovative R package and web application designed for robust and intuitive comparison of single-c

Our collaborators @rgottardo.bsky.social and Ken Stuart (+ others) describe tagtango, an application to compare #single-cell annotations.
#bioinformatics
academic.oup.com/bioinformati...

17.02.2025 21:34 β€” πŸ‘ 4    πŸ” 3    πŸ’¬ 0    πŸ“Œ 0
nipalsMCIA: Flexible Multi-Block Dimensionality Reduction in R via Nonlinear Iterative Partial Least Squares. Published in Bioinformatics (Oxford, England)

Unlocking new insights with nipalsMCIA. This tool speeds up data analysis for big datasets by clustering and visualizing info faster than before. Check it out for both bulk and single cell data on Bioconductor with how-to guides and extras online.

13.01.2025 02:03 β€” πŸ‘ 5    πŸ” 1    πŸ’¬ 0    πŸ“Œ 1
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nipalsMCIA: Flexible Multi-Block Dimensionality Reduction in R via Nonlinear Iterative Partial Least Squares https://www.biorxiv.org/content/10.1101/2024.06.07.597819v1 Motivation: With the increased reliance on multi-omics data for bulk and single cell analyses, the a

nipalsMCIA: Flexible Multi-Block Dimensionality Reduction in R via Nonlinear Iterative Partial Least Squares https://www.biorxiv.org/content/10.1101/2024.06.07.597819v1

10.06.2024 17:47 β€” πŸ‘ 1    πŸ” 1    πŸ’¬ 0    πŸ“Œ 0
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Interested in B cell receptor repertoire analysis? We have a great set of speakers lined up for the β€œ2025 Immcantation Users Group Meeting!” Check out the UPDATED program and register for this free virtual meeting taking place on 1/30/25 10AM-1:40PM (ET) at: immcantation.github.io/users-meetin...

30.01.2025 03:13 β€” πŸ‘ 2    πŸ” 1    πŸ’¬ 0    πŸ“Œ 0
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Don’t miss the β€œ2025 Immcantation Users Group Meeting” on 1/30/25 10AM-1:40PM (ET) to learn how AIRR-seq can be used to study infection, vaccination, clonal lineages, and more. **UPDATED PROGRAM** and registration: immcantation.github.io/users-meetin... #immcantation #AIRRseq #immunosky #immunology

29.01.2025 12:51 β€” πŸ‘ 1    πŸ” 1    πŸ’¬ 0    πŸ“Œ 0