Rubin Dasgupta

1H R1ρ Relaxation Identifies a Hidden Intermediate in DNA Base-Pairing 1H R1ρ Relaxation dispersion (RD) NMR experiments provide valuable atomic-level insights into transient, high-energy conformational states of biomolecules. However, cross-relaxation artifacts can hamp...

Check out our latest #NMR study together with @stonebutcher.bsky.social at @katjapetzold.bsky.social lab on an intermediate state of #DNA existing between the well-known Watson–Crick-Franklin and Hoogsteen base pairs stabilised by an anticancer drug Actinomycin D www.biorxiv.org/content/10.1...

Check out our new method for targeted DNP-enhanced NMR of RNA using site-directed spin labeling, now live as a preprint on ChemRxiv:

doi.org/10.26434/che...

A fruitful collaboration with my colleague @rubindg.bsky.social and the group of Prof. Snorri Th. Sigurdsson from the University of Iceland.

Looking forward to discuss #RNA #Science at the 30th @rnasociety.bsky.social meeting. I will be presenting our recent work on employing state-of-the-art #solid-state #NMR methods to study dynamics in microRNA-Argonaute complex in the Concurrent session 16 about miRNA and siRNA (T-149).

Congratulations 🎉

That’s a very dedicated purification 😅

For the last year I spent sometime learning #ONT #Nanopore sequencing and we decided to get this amazing P2 Solo. Can’t wait to start acquiring some in-house data. #RNAbiology #ChemicalProbing #RNA

Amazing article highlighting the important discoveries in RNA biology cementing its role in evolution of life

Elucidating microRNA-34a organisation within human Argonaute-2 by dynamic nuclear polarisation-enhanced magic angle spinning NMR Abstract. Understanding mRNA regulation by microRNA (miR) relies on the structural understanding of the RNA-induced silencing complex (RISC). Here, we eluc

Can increasing the sensitivity of #NMRspectroscopy provide some insight into #microRNA and #Argonaute interaction?
The answer is a resounding Yes.
Find out more in our recent study where we used #DynamicNuclearPolarisation to study this complex
doi.org/10.1093/nar/...