@pliotasgroup.bsky.social
Mechanosensitive channels & Membrane Proteins - Structural EPR Spectroscopy at The University of Manchester - DEER/PELDOR/PDS pliotasgroup.org
Funded by @ukri.org
@mcf-uom.bsky.social @uommib.bsky.social @fbmh-uom.bsky.social
In our study @elife.bsky.social we uncover the mechanism of mPPase inhibition. Over 20x structures to date are in a symmetric form. We use EPR(PELDOR/DEER) and reveal asymmetric binding at the active site while maintaining symmetric conformation at periplasmic site
elifesciences.org/reviewed-pre...
@Bruker's ELEXSYS E580Q Spectrometer has found its new home at the University of Manchester (@OfficialUoM)!
Watch as an empty lab is turned into a cutting-edge #EPR lab & hear from Prof. Christos Pliotas, who leads the research group driving innovation.
👉 youtu.be/Hz4fCqh8PeY [youtu.be]
webinar poster
Wednesday, April 23, 9 am EDT / 3 pm CEST, IVEM webinar, Christos Pliotas @pliotasgroup.bsky.social University of Manchester, Accessing uncharted membrane protein ensembles by structural biological EPR spectroscopy www.eprseminars.org #NMRchat #NMR #EPR #ESR 🧲 🧪
16.04.2025 19:21 — 👍 2 🔁 2 💬 0 📌 02025 IES John Weil Young Investigator Award: Nino Wili his outstanding contributions to theory and instrumentation in the field of EPR spectroscopy.
17.03.2025 15:21 — 👍 9 🔁 3 💬 0 📌 02025 IES Medal in Biology/Medicine: awarded to Olav Schiemann for his seminal contributions advancing the field of EPR in Biology via his pioneering efforts to resolve structural aspects of spin labelled nucleic acids and proteins.
17.03.2025 15:22 — 👍 6 🔁 2 💬 0 📌 0Early-career fellowships at the University of Manchester!
To celebrate 200 years of The University of Manchester, the Faculty of Biology Medicine and Health offers a 3-year Postdoctoral Fellowship to support exceptional early-career researchers:
www.bmh.manchester.ac.uk/research/sup...
Apply now for the 10th EFEPR Summer School in Manchester, UK, 31st Aug – 6th Sept 2025.
Attendees will receive training in advanced EPR theory & methods including hands on practical sessions. chemistry.manchester.ac.uk/epr/connect/... Expression of interest deadline: 21st Mar 2025
& Collab with @stemuench.bsky.social @drjonlippiat.bsky.social @astbury-bsl.bsky.social @astburycentre.bsky.social @mcf-uom.bsky.social @uommib.bsky.social @mariangeladiony.bsky.social
10.02.2025 21:55 — 👍 3 🔁 0 💬 0 📌 0
In our recent article we show the YbiO mechanosensitive channel can achieve pore openings of 3nS under membrane tension equalling the largest known gated-pore MscL and we also solve a cryo- EM structure of a YbiO in a sub-open state. Great effort by @lane-b.bsky.social www.cell.com/structure/fu...
10.02.2025 21:49 — 👍 16 🔁 5 💬 1 📌 2
We reviewed recent pulsed EPR Spectroscopy (PELDOR/DEER/PDS) applications on integral membrane proteins, enabled through Spin Labelling. Great to see the field moving forward!
www.sciencedirect.com/science/arti...
New starter pack on EPR - ESR spectroscopy: go.bsky.app/KJZ4P8X
24.01.2025 00:32 — 👍 13 🔁 3 💬 0 📌 0
