Myelin Lab

A flyer displaying the same information as written in the post, with two images of two astrocytes around a blood vessel and one newly formed oligodendrocyte, along with logs our sponsors Avantor and Plasmidsaurus.

If you are attending #SfN25, please join @amygleichman.bsky.social and I on Monday at 9PM for a casual social gathering to discuss all things non-neuronal!

Date: Monday, Nov 17th
Time: 9PM till close
Location: The Smoking Gun SD, 555 Market St.

All welcome, please free to spread the word!

Myelin injury precedes axonal injury and symptomatic onset in multiple sclerosis - Nature Medicine Myelin damage in multiple sclerosis can be detected up to 7 years before symptoms, with early immune pathway activation and a 21-protein panel showing promise for presymptomatic diagnosis.

www.nature.com/articles/s41...

Economics Nobel prize won by researchers who showed how science boosts growth Joel Mokyr, Philippe Aghion and Pewter Howitt share economics prize for work that underlines the importance of investing in research and development.

Joel Mokyr, Philippe Aghion and Pewter Howitt share economics prize for work that underlines the importance of investing in research and development.

go.nature.com/4hj9NNV

Targeting prostaglandin E2 receptor 2 in Schwann cells inhibits inflammatory pain but not inflammation - Nature Communications Non-steroidal anti-inflammatory drugs (NSAIDs) are known to alleviate pain by reducing inflammation. To the contrary, here, the authors show that selective inhibition of the prostaglandin E2 receptor (EP2) in Schwann cells eliminates pain without disrupting the protective and healing functions of inflammation.

NSAIDs are known to alleviate pain by reducing inflammation. A study in Nature Communications shows that selective inhibition of the prostaglandin E2 receptor in Schwann cells eliminates pain without disrupting the protective and healing functions of inflammation. #medsky 🧪

Spatial lipidomics reveals demyelination and remyelination dynamics in the mouse brain Myelin pathology in demyelinating diseases is accompanied by lipid remodeling that remains challenging to characterize at spatial level using traditio…

Remyelinated fibers have a distinct lipid profile compared to intact myelin
www.sciencedirect.com/science/arti...

Deletion of murine Sarm1 results in a microenvironment that delays peripheral nerve regeneration after injury In Sarm1-deficient mice, peripheral nervous system regeneration is delayed after injury.

Paper Alert!! Our collaborative work with Giger Lab at UMich is out now in #ScienceTranslationMedicine Deletion of murine Sarm1 results in a microenvironment that delays peripheral nerve regeneration after injury | Science Translational Medicine @science.org
www.science.org/doi/10.1126/...

Medicine Nobel goes to scientists who revealed secrets of immune system ‘regulation’ Mary Brunkow, Fred Ramsdell and Shimon Sakaguchi discovered cells that protect the body from autoimmune diseases.

This year’s Nobel Prize in Physiology or Medicine has been awarded to three scientists for discovering a class of immune cells that help to prevent the body from attacking its own tissues

go.nature.com/48QDdAJ

Post-Synaptic Density Proteins in Oligodendrocytes are Required for Activity-Dependent Myelin Sheath Growth Neuronal activity regulates myelination in the central nervous system, highlighting the critical importance of axon-oligodendrocyte communications in …

"Post-Synaptic Density Proteins in Oligodendrocytes are Required for Activity-Dependent Myelin Sheath Growth"
www.sciencedirect.com/science/arti...

Gtf2i-encoded transcription factor Tfii-i regulates myelination via Sox10 and Mbp regulatory elements - Nature Communications The transcriptional regulation of oligodendrocytes has an essential role in myelin formation and maintenance. Here, the authors identify the transcription factor Tfii-i as a regulator of myelin genes expression in the nervous system and show that its loss enhances myelin thickness and nerve conduction.

🚀 Our new paper is out in Nature Communications!

We uncovered a mechanistic switch to boost myelination: deleting Gtf2i in myelinating glia enhances Sox10/Mbp activity → thicker myelin, faster conduction, improved motor coordination.

Open access link:

www.nature.com/articles/s41...

What Happens When Scientists Flip the Switch on PMP22? | Charcot–Marie–Tooth Association What happens when scientists flip a hidden switch inside nerve cells? A CMTA-funded $281,339 study is testing whether this discovery could finally bring new ...

cmtausa.org/simply-cmt/c...

Metformin alters mitochondria-related metabolism and enhances human oligodendrocyte function Nature Communications - Metformin is under clinical trial for brain neuroprotection but how it may work is poorly understood. Here, the authors show that metformin helps myelin formation by human...

Our new paper on metformin, myelin, mitochondria and metabolism is now out at rdcu.be/eDbFD
Thanks to Nina and all of the team!

Transient gene melting governs the timing of oligodendrocyte maturation Oligodendrocyte maturation is governed by an SOX6-dependent gene-melted chromatin state at multiple immaturity loci. Reducing SOX6 accelerates maturation, offering a potential strategy to regenerate myelin in diseases like multiple sclerosis.

Now online! Transient gene melting governs the timing of oligodendrocyte maturation

Emerging connections between myelin and Alzheimer’s disease - Nature Cell Biology Recent literature has explored the contributions of oligodendrocytes and myelin dysfunction to Alzheimer’s disease. Here, we discuss emerging evidence that oligodendrocytes may directly contribute to ...

Emerging connections between myelin and Alzheimer’s disease

www.nature.com/articles/s41...

www.nature.com/articles/s41...

PNS Training Grant Program - Mobility Requirement Waived for All Applicants & Other Exciting Updates - pnsociety.com

Very excited by the updates to the PNS fellowship!

pnsociety.com/pns-training...

Magnificent!!

Successful networking event for Peripheral Gliaphiles & friends #glia2025 #marseille

Euroglia is open !! #Glia2025

Call for 20 Assistant Professor positions Karolinska Institutet is a world-leading medical university with a long and proud history of ground-breaking research. We are now recruiting outstanding early-career researchers with particularly exce...

Karolinska is looking for 20 (!!) assistant professors and offering 6 year appointments with ~1M USD startup packages.

ki.se/en/about-ki/...

Happy to share our latest publication on subcellular myelin proteomics and structural changes in Alzheimer disease www.nature.com/articles/s41...

Receiving these awards, the support of both patients and our peers means a lot, and is a milestone achievement in our careers!

Second, we received the Charcot-Marie-Tooth Association STAR award for a 3-year project focused on testing the safety and efficacy of a new therapeutic drug for CMT1A. 2/3

We are extremely proud to announce that in the last weeks we received the support of two terrific associations.

First, Katie Lewis received the 2025 Peripheral Nerve Society Laura Feltri Basic Science fellowship, and will join our team for her postdoc to study axon-Schwann cell interactions 1/3

This is a very sad news. 😞

If you have some interest in Peripheral Glia, join us at the Black Stone on Tuesday July 8th!

RSVP: amc.az1.qualtrics.com/jfe/form/SV_...

Activity-driven myelin sheath growth is mediated by mGluR5 - Nature Neuroscience Employing pharmacology, genetics and all-optical approaches in zebrafish, Braaker et al. find that neuronal activity influences the growth of myelin sheaths along axons by signaling through metabotrop...

For those who want a distraction and/ or are interested, here's the latest from the group, led by Phil Braaker

www.nature.com/articles/s41...

🚨 The #GLIA2025 Plenary Lineup is 🔥
7 top scientists, 1 big meeting in sunny 'Marseille ☀️🧠

🧠 Bruno Weber
🧠 Kelly Monk
🧠 Klaus-Armin Nave
🧠 Nathalie Rouach
🧠 Anna Molofsky
🧠 Bart J.L. Eggen
🧠 Maiken Nedergaard

July 8–11 — join us for cutting-edge glial science.
🔗 glia2025.eu

#Neuroscience #glial

A phylogenetic tree showing the 51 taxa nominally significant in at least one test in the study. The trend in the legend indicates changes in abundance in affected twins as compared to unaffected twins. Font color corresponds to the significance of the corresponding statistical test. Black indicates Chi-squared; orange indicates linear mixed models.

Researchers transferred bacteria from the guts of multiple sclerosis patients and their healthy twins to mice. In susceptible mice, the microbes Eisenbergiella tayi and Lachnoclostridium caused multiple sclerosis-like disease. In PNAS: www.pnas.org/doi/10.1073/...

Thanks to my peer in the steering committee for such a smooth fitst run, @macnamaralab.bsky.social , @zuloagalab.bsky.social and Drs. Cheon, Fredman and Lamar!

Today we hosted our first Postdoctoral Discovery Forum @AlbanyMed.

👍Great Success!!👍

Congrats to Drs. Deswal, Brace, Kar and Rahtes for best presentation awards!🏆