Xiao Huang

@cp-immunity.bsky.social preview on IL-10-producing Treg cells that restrain tumor growth by suppressing IL-17 production in colorectal cancer
www.cell.com/immunity/ful...

Transcription factor Maf promotes expression of repressor Zeb2 to drive microglia development in primitive hematopoiesis How distinct hematopoietic waves generate specialized macrophage lineages remains unclear. Chen et al. identify separate transcriptional pathways controlling macrophage development during primitive versus definitive hematopoiesis and identify Maf and Jun as key regulators of Zeb2 expression that drive microglia formation during primitive hematopoiesis, revealing a unique regulatory program for microglia development.

Online now: Transcription factor Maf promotes expression of repressor Zeb2 to drive microglia development in primitive hematopoiesis

(1/2) Researchers from the Sloan Kettering Institute at MSK discovered that not all regulatory T cells behave the same way in tumors. Some help fight cancer, while others protect it.

Many thanks to funders @mskcancercenter.bsky.social, Cancer Research Institute, and @ludwigcancer.bsky.social at Sloan Kettering. 8/8

Special thanks to my mentors Sasha Rudensky and Christina Leslie for their guidance and support, and to Dan Feng and @snehamitra.bsky.social for their invaluable contributions to this work. 7/8

Huge thanks to all our collaborators and coauthors who made this work possible. 6/8

Importantly, this functional heterogeneity is conserved in human CRC and extends to other barrier-tissue cancers. 5/8

These two Treg cell subsets also exhibit opposite enrichment patterns between adjacent normal colon tissues and tumors. 4/8

We found that IL-10⁺ Treg cells restrain tumor growth by suppressing IL-17 production from CD4⁺ T cells, whereas IL-10⁻ Treg cells promote tumor growth. 3/8

To dissect Treg cell heterogeneity in MSS CRC, we employed the AKP organoid model, which closely recapitulates key features of human disease. 2/8

Excited to share our new study, the paper is out today @cp-immunity.bsky.social! Not all Treg cells are the same. We identified two Treg cell subsets with opposing functions in colorectal cancer (CRC). 1/8

#BestPartOfScience: Learning to live with questions and walk beside uncertainty. Keep climbing toward understanding with others who are committed to the same journey, knowing that each peak is simply a place to begin again. #BecomingASceintist: Seeing loved ones face illness made me curious about how the body defends itself. I was drawn to the immune system for its complexity, and for what it reveals about resilience, timing, and care. #FunFuct: I spend time with my plants, watching small shifts, from a new leaf to how light shapes growth over time. They have taught me to notice patterns and respect the kind of timing that can't be forced. I also play video games, where the pace is faster, and failure is part of the process. You fall, rethink, and try again. Along the way, you meet teammates who challenge and support you. In science, I carry both rhythms with me. Xiao Huang, PhS Rudensky Lab National Postdoc Appreciation Week September 2025

Meet #MSKPostdoc Xiao Huang (@drxiaohuang.bsky.social) from the Rudensky Lab! Xiao investigates how different subsets of regulatory T (Treg) cells adapt to tissues and immune challenges to maintain immune balance in health and disease. #NPAW2025 🇨🇳

Enkephalin-producing regulatory T cells in the skin restrain local inflammation through control of nociception Regulatory T cells curb noxious sensory signaling to dampen cutaneous inflammation, a neuromodulatory mechanism for immunosuppression.

After many years of work I’m so happy to share our work on #scienceimmunology on how Treg cells modulate nociception to dampen skin inflammation! My handle will make a lot more sense now!🕵🏻‍♀️