Proteases and Innate immunity lab @ York

10 things you wish you knew about inflammatory caspases: a holistic review of their biochemistry, activation, and signalling Caspases are a family of cysteine proteases conserved across all multicellular life which play critical functions that range from cell death, inflammation and cellular differentiation. Caspases cleave...

10 things you wish you knew about inflammatory caspases: a holistic review of their biochemistry, activation, and signalling - Journal of Biological Chemistry www.jbc.org/article/S002...

Naomi after a successful Western blot!

(1/3) We've been catching up with our GenerationResearch students so far this summer..!

"Hi, I am Naomi, a Biomedical Sciences student going into the final year of my Integrated Masters at York. I am currently doing my Generation Research studentship in Dave Boucher's Lab.

🔥 Last call! Today’s the FINAL day to submit your abstract for “Innate immunity & inflammation: UK inflammation 2025.”

Don’t miss your chance to get involved! Submit now and join leading experts this September in Manchester.

Event & submission info: bit.ly/43q9x9r

Still time to register to the next BSI Innate Immunity and Inflammation meeting. Join us for 2 days packed with great science and networking opportunities!

Still time to register to the next BSI Innate Immunity and Inflammation meeting. Join us for 2 days packed with great science and networking opportunities!

Congratulations to the winner of the 2025 BSI Outstanding Leadership Award, sponsored by @ceijournal.bsky.social … Professor Clare Bryant, @clarebryant.bsky.social

Interested in innate immunity and inflammation? Join us in September for a great meeting! Superb lineup of speaker and lots of opportunities for Ecrs to present!

Interested in #InnateImmunity ? Register now to secure your spot — abstracts can be submitted later!
More info: wp.unil.ch/immunobiolog...

#ImmunoSky

Caspase-1 self-terminates protease activity to enforce homeostasis and prevent inflammasome-driven diseases Signal shutdown mechanisms must exist to silence the potent inflammatory programs initiated by the caspase-1 (CASP1) protease, to allow inflammation to resolve and reinstate tissue homeostasis. It is ...

Great work by the @inflammasomelab.bsky.social @s-burgener.bsky.social and colleagues showing in vivo the importance of caspase-1 inactivation in controlling inflammation! Impressive amount of work behind it, glad to see this out!
www.biorxiv.org/content/10.1...

We have a 3-year PDRA post in Cancer Immunogenomics. Ideal to use and strengthen your bioinformatics skills to discover how cancer transcriptome quirks shape immunotherapy outcomes. Funded by @cancerresearchuk.org. It’ll be fun!
jobs.york.ac.uk/vacancy/rese...
@hyms.ac.uk
@ybri-uoy.bsky.social

🔥 Open postdoc position in human inflammation-driven control of infection! 🔥
Join me at the University of Geneva, Switzerland this summer as I’m moving my Wellcome-funded research activity to the Department of Microbiology and Molecular Medicine! (1/5)

Please share!

Using AI-driven computer vision and high-throughput multiplexed human cell infection assays to dissect intra- and intercellular signalling networks and discover new antimicrobials at Queen’s Universit... PhD Project - Using AI-driven computer vision and high-throughput multiplexed human cell infection assays to dissect intra- and intercellular signalling networks and discover new antimicrobials at Que...

Funded 4-year #PhD in the exciting BBSRC NILAB program. @wwiem-qub.bsky.social

Receive multidisciplinary training, develop #infection models and #AI image analysis to reveal bacterial & viral disease mechanisms & discover new antimicrobials. Fight #AMR

Get in touch!
Details: tinyurl.com/e5k6ptua

Great work Jelena and team! well-done!

TBK1 and IKKε prevent premature cell death by limiting the activity of both RIPK1 and NLRP3 death pathways TBK1 and IKKe prevent premature cell death by limiting the activity of multiple death pathways in myeloid cells.

The loss of TBK1, or both TBK1 and the related kinase IKKε, results in uncontrolled cell death–driven inflammation. We show that TBK1/IKKε prevent premature cell death by limiting the activity of multiple death pathways in myeloid cells. www.science.org/doi/10.1126/...

#job 🚨for a laboratory technician in the Wright group within dept. Biology/HYMS and @ybri-uoy.bsky.social to work on creating genome-scale arrays of human cell surface receptors to discover new host-pathogen interactions. Apply by 20/3/2025: jobs.york.ac.uk/vacancy/labo...

#job - INTERNAL candidates only. Technician in dept. Biology in @billgrey.bsky.social lab studying how the proteome evolves from healthy haematopoietic stem cell to malignant leukaemic stem cell in vivo. Apply by 12/3/25 jobs.york.ac.uk/internal/vac...

Can I tempt some young minds to consider Old York for a PhD?

Some days left to apply.
Open to applicants WORLDWIDE 🌎.

Principal Scientist (Biochemistry/Enzymology) 4,000 professionals, 0 days wasted, 1 incredible purpose. Together, we are beating cancer. Principal Scientist – Biochemistry/Enzymology Starting salary: From £50,400-£57,400 per annum depending on ex...

We’re currently recruiting for a biochemist, to be based here in Glasgow at the @cruk-si.bsky.social or otherwise down in Cambridge. Take a look, and obviously choose Glasgow! cancerresearchuk.wd3.myworkdayjobs.com/en-US/Extern...

What’s in our bin?: Labs kick off and demand the transition towards a circular economy for lab plastics: EMBO reports: Vol 26, No 2 EMBO Press is an editorially independent publishing platform for the development of EMBO scientific publications.

Great piece on circular/green labs (sent by @cyrilpedia.bsky.social). More urgent than ever: www.embopress.org/doi/full/10....

<em>Immunology & Cell Biology</em> | ASI Journal | Wiley Online Library Positive research cultures provide the environment for scientists to explore ideas, grow as individuals, develop team science and create a positive impact on those around them. Here we focus on key a...

Academics get so jaded about institutions, when they reach a #leadership position many feel #researchculture is unactionable. Me and @deefitzgerald.bsky.social wrote a guide in @immunolcellbiol.bsky.social on leadership nurturing a positive culture 1/13

onlinelibrary.wiley.com/doi/10.1111/...

Plasticity of cell death pathways ensures GSDMD activation during Yersinia pseudotuberculosis infection Injection of YopJ by Yersinia pseudotuberculosis triggers RIPK1-dependent caspase-8 and GSDMD activation in murine macrophages; however, how macrophages defend against Yersinia when caspase-8 or YopJ ...

Thrilled to start 2025 with our latest findings! Yersinia invades macrophage cytosol to activate caspase-11 when caspase-8 or YopJ are inactive. www.cell.com/cell-reports...

There's still time to apply for this postdoc position in our lab. Ideally suited to someone wanting to develop some independent research, we have lots of new projects to select from! #immunosky 🧪

Pyroptotic cell corpses are crowned with F-actin-rich filopodia that engage CLEC9A signaling in incoming dendritic cells Nature Immunology - Pyroptotic cell death results in inflammation. Here the authors find that F-actin-rich structures formed during macrophage pyroptosis persist after cell death to activate...

Have you ever wondered whether pyroptotic corpses have functions beyond the grave? We made the surprising discovery that pyroptotic corpses are flagged by #filopodia to alert #DendriticCells they need autopsy. A short Bluetorial (1/13)👇with movies!
Link: rdcu.be/d2mjm

Distinct roles for the Staphylococcus aureus POT transporter DtpT in di/tripeptide uptake and glutathione utilisation inside human macrophages Peptides available in biological niches inhabited by the human pathogen Staphylococcus aureus serve as a rich source of amino acids required for growth and successful host colonisation. Uptake of pept...

Preprint alert!

Peptides are everywhere in biological environments, and these molecules serve as a rich source of nutrients for bacteria. Here, we uncover how one transporter protein allows S. aureus to utilise 100+ peptides for growth

www.biorxiv.org/content/10.1...

Distinct roles for the Staphylococcus aureus POT transporter DtpT in di/tripeptide uptake and glutathione utilisation inside human macrophages Peptides available in biological niches inhabited by the human pathogen Staphylococcus aureus serve as a rich source of amino acids required for growth and successful host colonisation. Uptake of pept...

Another preprint, and this time the excellent work of @imrsankhan.bsky.social from his PhD & our first full experimental Staph aureus paper - on transporters of course! Imran found a cool link to glutathione and infection too.
www.biorxiv.org/content/10.1...

MRC DiMeN Doctoral Training Partnership: Can skin inflammation stop mosquito-borne virus infection? at University of York on FindAPhD.com PhD Project - MRC DiMeN Doctoral Training Partnership: Can skin inflammation stop mosquito-borne virus infection? at University of York, listed on FindAPhD.com

Excited by viruses and how our bodies repel them? A fully funded PhD project now available combining expertise from the lab to the clinic. #virology #immunology #dermatology #CRISPR #vector-vertebrate biology. Help us spread the word. ☺️

www.findaphd.com/phds/project...

📢 PhD Alert!
Join us for an exciting PhD project in gorgeous York 🧠 🔬

You will be based in the Hahnlab (sites.google.com/york.ac.uk/hah…) in gorgeous York & work with an interdisciplinary team of researchers. Happy to chat!
Apply here: lnkd.in/es-nY8uD

#PhDposition

CASE Project: Unravelling the role of extracellular vesicles in the orchestration of macrophage – mediated immune regulation. at University of York on FindAPhD.com PhD Project - CASE Project: Unravelling the role of extracellular vesicles in the orchestration of macrophage – mediated immune regulation. at University of York, listed on FindAPhD.com

PhD project with Ioannis Kourtzelis, our lab and Mesenbio in lovely York! Macrophage, EV and innate immune responses, what's not to love! www.findaphd.com/phds/project...

sure thing :)

Hey Cheri, I just added you 😀. Welcome to the group!