Proteases and Innate immunity lab @ York

With all the excitement about AI giving us answers, we often forget that the real trick is to figure out what is the question.

Jo in our team - we are looking for a PhD student, postdoc or lab manager!

More information and links to job portal for application submission:

lnkd.in/dcU2Vg7W

lnkd.in/dgVKTARV

Please share widely 🙏🏼
@yefis-immunology.bsky.social @syis-ecr.bsky.social

dave boucher PhD Projects, Programmes & Scholarships - 3 PhDs Listed FindAPhD. Search Funded PhD Projects, Programmes & Scholarships in dave boucher. Search for PhD funding, scholarships & studentships in the UK, Europe and around the world.

Correct link: www.findaphd.com/phds/?Keywor...

dave boucher PhD Projects, Programmes & Scholarships - 3 PhDs Listed FindAPhD. Search Funded PhD Projects, Programmes & Scholarships in dave boucher. Search for PhD funding, scholarships & studentships in the UK, Europe and around the world.

Correct link: www.findaphd.com/phds/?Keywor...

3 PhD positions in the lab for British Students. Inflammasome, cell death and skin immunity, with fantastic colleagues. Check them out or share it with curious and motivated PhD students: www.findaphd.com/phds/?Keywor... @yorkshirebiodtp.bsky.social @ybri-uoy.bsky.social @biologyatyork.bsky.social

Archaeal cells whose DNA has been stained with a blue dye. Zoomed-in images of mutant cells that display chromosome segregation defects.

High-resolution images of DNA-protein complexes obtained with atomic force microscopy. Upon binding, the protein bridges distant sites, forming loops.

📢 Interested in #chromosomes 🧬 & #archaea thriving at the edge of life? PhD project in York,UK on how archaea pass on their genome to daughter cells.Friendly supervisors: me, @steve-quinn-lab.bsky.social & @georgerheath.bsky.social

www.findaphd.com/phds/project...
📅 January 7, 2026
Please RP🙏thx!

Human non-canonical inflammasomes activate CASP3 to limit intracellular Salmonella replication in macrophages. Inflammasomes are multiprotein signaling platforms that activate inflammatory caspases to induce pyroptosis. In humans, canonical inflammasomes activate CASP1, which cleaves the pore-forming protein g...

The story nicely complement a new preprint from Cornelius Taabazuing lab at UPenn on how caspase-4 can control Salmonella infections through Gasdermins and caspase-3. www.biorxiv.org/content/10.1...

Evolutionary convergence of a Pyroptosis-Apoptosis crosstalk drives non-canonical inflammasome signalling. The coordination of efficient immune responses to infections is essential to enable pathogen clearance and host survival. Cell death modalities are a crucial component of the innate immune system and ...

New story from the lab by PhD student Seb Grant. Started as a summer project and developed into an interesting story.
www.biorxiv.org/content/10.1...

Interested in joining the Powrie Lab? We’re looking for a Postdoctoral Researcher to study the neutralisation capacity of human anti-IL-10 autoantibodies. You’ll be part of our new MRC CoRE in Exposome Immunology!🧫🦠

Find out more here & apply by 11th Nov: bulletin.ndorms.ox.ac.uk/c/126QDJVBd0...

🔔 Chech out this new cool story on non-canonical inflammasome signaling in NK cells by @protinnimmunity.bsky.social

Thanks Sabrina :)

SAVE THE DATE!

The 2026 UK CellularMicrobiologyNetwork meeting will be held 22nd - 23rd of June at @wwiem-qub.bsky.social in Belfast.

Researchers from the UK and beyond are invited to share exciting work on the mechanisms of host-pathogen interactions.

Follow us to stay tuned! www.ukcellmicro.org

The second day of the @dib-unil.bsky.social #PRR symposium kicks off with more excellent talks including our own Jakub Began.

📢A new effector-triggered immunity role for GBP1! No place for pathogens to hide now that GBP1 can detect extracellular pathogens that hijack the actin cytoskeleton. Surprise*suprise* GBP1 does this independently of LPS! 🧵
biorxiv.org/content/10.1...

For our #flowcytometry peeps, would you like to have a single fix/perm protocol that is optimised for everything? One that preserves fluorophores while allowing simultaneous TF and cytokine staining? How about 100-fold cheaper?

You got it:
currentprotocols.onlinelibrary.wiley.com/doi/10.1002/...

Ready to start 2 days of everything innate immunity and inflammation #bsiinflammation2025
@britsocimm.bsky.social

Looking for passionate candidate to apply to PhD fellowship to University of Murcia call:

www.um.es/documents/d/...

Interested students contact me!

Commensal yeast promotes Salmonella Typhimurium virulence - Nature Commensal Candida albicans enhances the virulence and dissemination of Salmonella enterica subsp. enterica serovar Typhimurium.

#MycobiotaPower! Exciting work @nature.com by Behnsen, Jaswal &co showing that #Salmonella uses type 3 secretion system to hijack #Candida_albicans to produce arginine in the gut, boosting Salmonella infectivity & reducing the immune response! www.nature.com/articles/s41...

So excited that this study is now online! It's been a pleasure to work with BioAge Labs and our collaborators on this story. We characterise a new class of #NLRP3 inhibitors with translational potential for so many inflammatory diseases.

Still time to register for the BSI inflammation meeting 2025! Don’t miss out on this fantastic meeting !.

10 things you wish you knew about inflammatory caspases: a holistic review of their biochemistry, activation, and signalling Caspases are a family of cysteine proteases conserved across all multicellular life which play critical functions that range from cell death, inflammation and cellular differentiation. Caspases cleave...

10 things you wish you knew about inflammatory caspases: a holistic review of their biochemistry, activation, and signalling - Journal of Biological Chemistry www.jbc.org/article/S002...

Naomi after a successful Western blot!

(1/3) We've been catching up with our GenerationResearch students so far this summer..!

"Hi, I am Naomi, a Biomedical Sciences student going into the final year of my Integrated Masters at York. I am currently doing my Generation Research studentship in Dave Boucher's Lab.

🔥 Last call! Today’s the FINAL day to submit your abstract for “Innate immunity & inflammation: UK inflammation 2025.”

Don’t miss your chance to get involved! Submit now and join leading experts this September in Manchester.

Event & submission info: bit.ly/43q9x9r

Still time to register to the next BSI Innate Immunity and Inflammation meeting. Join us for 2 days packed with great science and networking opportunities!

Still time to register to the next BSI Innate Immunity and Inflammation meeting. Join us for 2 days packed with great science and networking opportunities!

Congratulations to the winner of the 2025 BSI Outstanding Leadership Award, sponsored by @ceijournal.bsky.social … Professor Clare Bryant, @clarebryant.bsky.social

Interested in innate immunity and inflammation? Join us in September for a great meeting! Superb lineup of speaker and lots of opportunities for Ecrs to present!

Interested in #InnateImmunity ? Register now to secure your spot — abstracts can be submitted later!
More info: wp.unil.ch/immunobiolog...

#ImmunoSky

Caspase-1 self-terminates protease activity to enforce homeostasis and prevent inflammasome-driven diseases Signal shutdown mechanisms must exist to silence the potent inflammatory programs initiated by the caspase-1 (CASP1) protease, to allow inflammation to resolve and reinstate tissue homeostasis. It is ...

Great work by the @inflammasomelab.bsky.social @s-burgener.bsky.social and colleagues showing in vivo the importance of caspase-1 inactivation in controlling inflammation! Impressive amount of work behind it, glad to see this out!
www.biorxiv.org/content/10.1...

We have a 3-year PDRA post in Cancer Immunogenomics. Ideal to use and strengthen your bioinformatics skills to discover how cancer transcriptome quirks shape immunotherapy outcomes. Funded by @cancerresearchuk.org. It’ll be fun!
jobs.york.ac.uk/vacancy/rese...
@hyms.ac.uk
@ybri-uoy.bsky.social