Proteases and Innate immunity lab @ York

SAVE THE DATE!

The 2026 UK CellularMicrobiologyNetwork meeting will be held 22nd - 23rd of June at @wwiem-qub.bsky.social in Belfast.

Researchers from the UK and beyond are invited to share exciting work on the mechanisms of host-pathogen interactions.

Follow us to stay tuned! www.ukcellmicro.org

The second day of the @dib-unil.bsky.social #PRR symposium kicks off with more excellent talks including our own Jakub Began.

📢A new effector-triggered immunity role for GBP1! No place for pathogens to hide now that GBP1 can detect extracellular pathogens that hijack the actin cytoskeleton. Surprise*suprise* GBP1 does this independently of LPS! 🧵
biorxiv.org/content/10.1...

For our #flowcytometry peeps, would you like to have a single fix/perm protocol that is optimised for everything? One that preserves fluorophores while allowing simultaneous TF and cytokine staining? How about 100-fold cheaper?

You got it:
currentprotocols.onlinelibrary.wiley.com/doi/10.1002/...

Ready to start 2 days of everything innate immunity and inflammation #bsiinflammation2025
@britsocimm.bsky.social

Looking for passionate candidate to apply to PhD fellowship to University of Murcia call:

www.um.es/documents/d/...

Interested students contact me!

Commensal yeast promotes Salmonella Typhimurium virulence - Nature Commensal Candida albicans enhances the virulence and dissemination of Salmonella enterica subsp. enterica serovar Typhimurium.

#MycobiotaPower! Exciting work @nature.com by Behnsen, Jaswal &co showing that #Salmonella uses type 3 secretion system to hijack #Candida_albicans to produce arginine in the gut, boosting Salmonella infectivity & reducing the immune response! www.nature.com/articles/s41...

So excited that this study is now online! It's been a pleasure to work with BioAge Labs and our collaborators on this story. We characterise a new class of #NLRP3 inhibitors with translational potential for so many inflammatory diseases.

Still time to register for the BSI inflammation meeting 2025! Don’t miss out on this fantastic meeting !.

10 things you wish you knew about inflammatory caspases: a holistic review of their biochemistry, activation, and signalling Caspases are a family of cysteine proteases conserved across all multicellular life which play critical functions that range from cell death, inflammation and cellular differentiation. Caspases cleave...

10 things you wish you knew about inflammatory caspases: a holistic review of their biochemistry, activation, and signalling - Journal of Biological Chemistry www.jbc.org/article/S002...

Naomi after a successful Western blot!

(1/3) We've been catching up with our GenerationResearch students so far this summer..!

"Hi, I am Naomi, a Biomedical Sciences student going into the final year of my Integrated Masters at York. I am currently doing my Generation Research studentship in Dave Boucher's Lab.

🔥 Last call! Today’s the FINAL day to submit your abstract for “Innate immunity & inflammation: UK inflammation 2025.”

Don’t miss your chance to get involved! Submit now and join leading experts this September in Manchester.

Event & submission info: bit.ly/43q9x9r

Still time to register to the next BSI Innate Immunity and Inflammation meeting. Join us for 2 days packed with great science and networking opportunities!

Still time to register to the next BSI Innate Immunity and Inflammation meeting. Join us for 2 days packed with great science and networking opportunities!

Congratulations to the winner of the 2025 BSI Outstanding Leadership Award, sponsored by @ceijournal.bsky.social … Professor Clare Bryant, @clarebryant.bsky.social

Interested in innate immunity and inflammation? Join us in September for a great meeting! Superb lineup of speaker and lots of opportunities for Ecrs to present!

Interested in #InnateImmunity ? Register now to secure your spot — abstracts can be submitted later!
More info: wp.unil.ch/immunobiolog...

#ImmunoSky

Caspase-1 self-terminates protease activity to enforce homeostasis and prevent inflammasome-driven diseases Signal shutdown mechanisms must exist to silence the potent inflammatory programs initiated by the caspase-1 (CASP1) protease, to allow inflammation to resolve and reinstate tissue homeostasis. It is ...

Great work by the @inflammasomelab.bsky.social @s-burgener.bsky.social and colleagues showing in vivo the importance of caspase-1 inactivation in controlling inflammation! Impressive amount of work behind it, glad to see this out!
www.biorxiv.org/content/10.1...

We have a 3-year PDRA post in Cancer Immunogenomics. Ideal to use and strengthen your bioinformatics skills to discover how cancer transcriptome quirks shape immunotherapy outcomes. Funded by @cancerresearchuk.org. It’ll be fun!
jobs.york.ac.uk/vacancy/rese...
@hyms.ac.uk
@ybri-uoy.bsky.social

🔥 Open postdoc position in human inflammation-driven control of infection! 🔥
Join me at the University of Geneva, Switzerland this summer as I’m moving my Wellcome-funded research activity to the Department of Microbiology and Molecular Medicine! (1/5)

Please share!

Using AI-driven computer vision and high-throughput multiplexed human cell infection assays to dissect intra- and intercellular signalling networks and discover new antimicrobials at Queen’s Universit... PhD Project - Using AI-driven computer vision and high-throughput multiplexed human cell infection assays to dissect intra- and intercellular signalling networks and discover new antimicrobials at Que...

Funded 4-year #PhD in the exciting BBSRC NILAB program. @wwiem-qub.bsky.social

Receive multidisciplinary training, develop #infection models and #AI image analysis to reveal bacterial & viral disease mechanisms & discover new antimicrobials. Fight #AMR

Get in touch!
Details: tinyurl.com/e5k6ptua

Great work Jelena and team! well-done!

TBK1 and IKKε prevent premature cell death by limiting the activity of both RIPK1 and NLRP3 death pathways TBK1 and IKKe prevent premature cell death by limiting the activity of multiple death pathways in myeloid cells.

The loss of TBK1, or both TBK1 and the related kinase IKKε, results in uncontrolled cell death–driven inflammation. We show that TBK1/IKKε prevent premature cell death by limiting the activity of multiple death pathways in myeloid cells. www.science.org/doi/10.1126/...

#job 🚨for a laboratory technician in the Wright group within dept. Biology/HYMS and @ybri-uoy.bsky.social to work on creating genome-scale arrays of human cell surface receptors to discover new host-pathogen interactions. Apply by 20/3/2025: jobs.york.ac.uk/vacancy/labo...

#job - INTERNAL candidates only. Technician in dept. Biology in @billgrey.bsky.social lab studying how the proteome evolves from healthy haematopoietic stem cell to malignant leukaemic stem cell in vivo. Apply by 12/3/25 jobs.york.ac.uk/internal/vac...

Can I tempt some young minds to consider Old York for a PhD?

Some days left to apply.
Open to applicants WORLDWIDE 🌎.

Principal Scientist (Biochemistry/Enzymology) 4,000 professionals, 0 days wasted, 1 incredible purpose. Together, we are beating cancer. Principal Scientist – Biochemistry/Enzymology Starting salary: From £50,400-£57,400 per annum depending on ex...

We’re currently recruiting for a biochemist, to be based here in Glasgow at the @cruk-si.bsky.social or otherwise down in Cambridge. Take a look, and obviously choose Glasgow! cancerresearchuk.wd3.myworkdayjobs.com/en-US/Extern...

What’s in our bin?: Labs kick off and demand the transition towards a circular economy for lab plastics: EMBO reports: Vol 26, No 2 EMBO Press is an editorially independent publishing platform for the development of EMBO scientific publications.

Great piece on circular/green labs (sent by @cyrilpedia.bsky.social). More urgent than ever: www.embopress.org/doi/full/10....

<em>Immunology & Cell Biology</em> | ASI Journal | Wiley Online Library Positive research cultures provide the environment for scientists to explore ideas, grow as individuals, develop team science and create a positive impact on those around them. Here we focus on key a...

Academics get so jaded about institutions, when they reach a #leadership position many feel #researchculture is unactionable. Me and @deefitzgerald.bsky.social wrote a guide in @immunolcellbiol.bsky.social on leadership nurturing a positive culture 1/13

onlinelibrary.wiley.com/doi/10.1111/...

Plasticity of cell death pathways ensures GSDMD activation during Yersinia pseudotuberculosis infection Injection of YopJ by Yersinia pseudotuberculosis triggers RIPK1-dependent caspase-8 and GSDMD activation in murine macrophages; however, how macrophages defend against Yersinia when caspase-8 or YopJ ...

Thrilled to start 2025 with our latest findings! Yersinia invades macrophage cytosol to activate caspase-11 when caspase-8 or YopJ are inactive. www.cell.com/cell-reports...