🧩 Findings suggest
Autoantibodies may represent an under-recognized source of psychiatric vulnerability in 22q11DS, acting alongside the genetic deletion
🔬 This perspective opens new directions for research and clinical consideration, including immunological screening
doi.org/10.1017/neu....
📄 Individuals with 22q11DS may develop
• increased circulating autoantibodies & elevated inflammatory markers,
• increased blood–brain barrier (BBB) permeability
• Converging evidence shows that antibodies targeting neural proteins can induce psychiatric symptoms
🧠🧬 Autoimmunity as an underexplored contributor to neuropsychiatric symptoms in 22q11.2 deletion syndrome
A recent study synthesizes evidence linking autoimmune processes to the neuropsychiatric phenotype observed in 22q11.2 deletion syndrome (22q11DS).
More importantly, these findings underscore that behavioral patterns and mental well-being are deeply connected.
This study highlights the need for integrated support frameworks and policies that address the root causes of mental health in adolescents.
doi.org/10.1017/neu....
It identifies strong links to underlying mental health:
•Food addiction was tied to depression, anxiety &stress
•Problematic internet use was linked to depression &stress
•Internet gaming disorder was associated with anxiety
The research reveals notable prevalence rates:
•Food addiction 6.9%
•Problematic internet use 14.3%
•Internet gaming disorder 0.9%
The high rate of problematic internet use reflects the digitally immersive world
How prevalent are behavioural addictions among adolescents?
A newly published study in Acta Neuropsychiatrica suggests insights by examining multiple behavioral addictions simultaneously.
📌 Clinically, this supports a nuanced view of BPD: social difficulties may be amplified by interpersonal stress and emotional load, not by a global inability to process fairness or social norms.
READ here for more: doi.org/10.1017/neu....
#Psychiatry #ClinicalPsychology
These findings suggest that social impairments in BPD may be context-dependent, rather than pervasive
Differences in behavior and neural processing may emerge primarily under stressful, disorder-relevant interpersonal contexts, rather than in neutral, one-shot interactions w/strangers
#Borderline
🔹 BPD showed higher overall rejection rates of monetary offers
🔹 recognized and responded to fairness norm violations similarly to controls
🔹 Neural data revealed different roles in the PFC:
• vmPFC encoded linear value (valence)
• dmPFC/dlPFC encoded quadratic salience (norm prediction errors)
Decision-making in Borderline Personality Disorder (BPD) in Social Context
A recent fMRI study publishe in Acta Neuropsychiatrica used a multi-round Ultimatum Game to examine fairness, norm violations, and value processing in individuals with BPD.
#fMRI #SocialCognition
As we approach the end of 2025, we would like to send a warm thank you to the entire Acta Neuropsychiatrica community —our dedicated authors, diligent reviewers & committed editorial board members.
On behalf of the Acta Neuropsychiatrica and the board of the SCNP.
⚠️ Caveats:
• As in psychiatry, no single, universal biomarker exists. The future likely lies in multi-marker panels.
• Findings are primarily preclinical; human translation is the next critical step.
Read more: doi.org/10.1017/neu....
#Neuroscience #Biomarkers #ASDResearch #Exosomes
🧬Mechanistics: Extracellular vesicles offer a dynamic snapshot of cellular communication
🩸Diagnostic: Accessibility makes low invasive diagnostical tool
💊Therapeutics: Administering exosomes derived from healthy sources has shown behavioral improvements in preclinical ASD models
🧩Exosomes: A New Frontier in Understanding & Treating Autism Spectrum Disorder (ASD)
How can they advance ASD research?
🔹 Understanding how the DDCS function across different vertebrates, supporting navigation, decision-making & stress resilience, may offer insights into human mental health and how our own brains cope (or fail) with displacement, uncertainty and change.
doi.org/10.1017/neu....
✨ At the center of this discussion is the dorsal diencephalic conduction system (DDCS)
• a highly conserved pathway (stria medullaris → habenula → fasciculus retroflexus)
• central to flexible responses in social, defensive, and reward-related contexts
• and a decisive hot spot in neuropsychiatry.
🧠 Our brain circuits were shaped under these conditions, and some of the most ancient pathways remain deeply conserved across vertebrate species.
This recent review highlights a fascinating framework: looking beyond mammals and exploring alternative models for studying human mental disorders.
🧭 Modern humans often face intense stress when uprooted from a familiar and safe environment… yet our nomadic ancestors evolved under constant movement as hunter-gatherers.
05.12.2025 19:12 — 👍 0 🔁 0 💬 1 📌 0
🌍 From nomadic origins to modern stress: what can birds teach us about mental health?
doi.org/10.1017/neu....
🔗 Check it out here: doi.org/10.1017/neu....
#psychedelics #neuroscience #neurorehab
Could the neural plasticity associated with psychedelics extend beyond mood or perception towards functional recovery itself?
✨ Interesting protocol alert: a randomised dose-comparison design testing whether psilocybin + physiotherapy can restore motor function and body–brain coherence.
🧠 Could psychedelics help rewire the brain–body disconnect?
💊 + 🧍♀️A new pilot study explores this question by investigating psilocybin-assisted therapy in Motor Functional Neurological Disorder (FND), pairing pharmacological and rehabilitative approaches.
🧠 These findings highlight how inclusive educational approaches can advance health literacy early in life and support equitable, scalable digital health strategies for diverse learning needs.
Read more here: doi.org/10.1017/neu....
💡 The hybrid format (digital + classroom) and easy-to-read, gamified materials made the program accessible, engaging, and equally effective across rural and urban schools, as well as regular and special education centers.
#HealthLiteracy #DigitalHealth #Neurodiversity #EquityInHealth
🩺 Building Early Pain Literacy
Pain-related knowledge can improve quality of life and satisfaction, and the sooner the better
✨In a new study, a pain neuroscience education (PNE) program significantly improved outcomes in adolescents with and without intellectual disabilities.
🧩 Clinical relevance:
Psilocybin shows promise as a novel, mechanism-distinct intervention for depression.
🔗 Read the full review: doi.org/10.1017/neu....
#Psilocybin #Depression #PsychedelicMedicine
🌿 Results:
Psilocybin produced rapid antidepressant effects, often after one or two supported sessions.
Improvements were sustained for several weeks or months.
Treatment is generally well-tolerated with some mild headaches and transient anxiety - typically manageable in controlled settings.
🍄 What does the evidence say on Psilocybin Therapy in Depression?
📄 A new PRISMA-guided systematic review analyzed 22 clinical studies, including randomized controlled + open-label trials.
Populations included treatment-resistant depression and varied dosing and adjunctive protocols
🎯 This ratio may be explored in precision therapeutics aimed at modulating TRYCAT metabolism to reduce neuroinflammation and cognitive impairment.
Read + here: doi.org/10.1017/neu....
#Psychiatry #Psychopharmacology #Neuroscience #TRYCAT #Schizophrenia #Inflammation #PrecisionMedicine
