Class-I myosin responds to changes in membrane tension during clathrin-mediated endocytosis in human induced pluripotent stem cells | PNAS www.pnas.org/doi/10.1073/...
24.02.2026 18:48 — 👍 9 🔁 4 💬 0 📌 1
Class-I myosin responds to changes in membrane tension during clathrin-mediated endocytosis in human induced pluripotent stem cells | PNAS www.pnas.org/doi/10.1073/...
24.02.2026 18:48 — 👍 9 🔁 4 💬 0 📌 1Excited to share our work on epithelial multilayering - identifying why stem cell stay in the basal layer and how and why differentiating cells move up. Great collab with @manningresearch.bsky.social and Niessen labs! Check out preprint and great summary below www.biorxiv.org/content/10.6...
10.02.2026 06:14 — 👍 84 🔁 37 💬 2 📌 1
#InMemoriam: Dr. Robert Bruce Nicklas, who spent over 50 years unraveling the mysteries of how #chromosomes move during #CellDivision, died on February 19, 2025, at the age of 92. Leocadia Paliulis commemorates his life and work. rupress.org/jcb/article/...
13.02.2026 17:01 — 👍 9 🔁 7 💬 0 📌 0
Myosin II regulates cellular thermo-adaptability and the efficiency of immune responses
www.cell.com/developmenta...
Proud and excited to share our work with the community! Helen @helenfoster.bsky.social Foster et al. study how #cilia axonemes are built. 👀 Don't miss the gorgeous and insightful movies by @margotriggi.bsky.social, they really show our discoveries in full action!
www.biorxiv.org/content/10.6...
Introducing The Structural History of Eukarya (SHE): The first proteome-scale phylogeny constructed entirely from 3D structure.
We computed 300 trillion alignments across 1,542 species to map the tree of life. 🧵👇 (1/5)
We’re excited to share our latest preprint! We identify SKT, a mechanosensitive adhesion protein that recruits mTORC2 to cell–matrix adhesions, linking metabolic demand to matrix stiffness. Disrupting this axis strongly inhibits PDAC tumor growth. shorturl.at/V0tpK
06.02.2026 10:35 — 👍 18 🔁 8 💬 2 📌 1@mathildemathieu.bsky.social @ivaskalab.bsky.social New discovery from us! Leupaxin, a paxillin family member typically expressed in immune cells, negatively regulates durotaxis and mechanoresponsiveness in metastatic breast cancer cell variants and in cells cultured on soft ECM lnkd.in/diEk8DSR
05.02.2026 09:33 — 👍 17 🔁 6 💬 0 📌 0
Our paper on how calcium controls lamellipodial actin assembly is out in Current Biology! Huge congrats to Ernest Iu, Alex Bogatch, and all the authors - fantastic collaboration!
www.sciencedirect.com/science/arti...
Calcium directs actin assembly via allosteric activation of formin INF2
www.biorxiv.org/content/10.6...
A FAST plant myosin (Chara MyoXI) drives formation of actin chiral rings
www.pnas.org/doi/10.1073/...
Four representative slices of cryo-tomograms showing annotated organelles.
New on the CryoET Data Portal: ~27,000 tomograms of affinity-captured lysosomes from HEK293T cells across 4 physiological states. Includes raw data, AreTomo3 reconstructions & Membrain-Seg annotations. Openly available for reuse!
cryoetdataportal.czscience.com/depositions/...
The conference (agreement between House and Senate) appropriations bill that includes HHS and NIH was released this morning.
www.appropriations.senate.gov/news/majorit...
1/5
Paper alert: Our study led by @evapillai.bsky.social and @sudimukherjee.bsky.social showing that mechanical properties of the #brain actively shape the molecular landscape during development and #axonpathfinding is finally out! www.nature.com/articles/s41... @pdncambridge.bsky.social @fau.de @MPZPM
19.01.2026 16:38 — 👍 85 🔁 27 💬 2 📌 5
Cartoon showing key challenges in evolutionary cell biology. This schematic illustrates four central challenges in the field: (1) integrating cell biology with evolutionary theory and experimental evolution, (2) bridging the genotype–phenotype gap, (3) identifying and developing new model systems, and (4) incorporating ecological context into evolutionary cell biology. Each quadrant highlights a conceptual hurdle that must be addressed to advance the discipline.
@gautamdey.bsky.social, @fritzlaylin.bsky.social, @alebenoit.bsky.social and @eelcotromer.bsky.social discuss how the field of evolutionary cell biology works to understand how cells evolve & diversify, highlighting current challenges & the future outlook.
journals.biologists.com/jcs/article/...
Join us to study developmental cell biology with a focus on cell migration and morphogenesis.
More info about our research:
www.bischofflab.com
Job posting and application details:
focalplane.biologists.com/cell-biology...
#Science #CellBio #DevBio #AcademicJobs #PhDJobs #PhDPosition #Drosophila
New paper out!
We show how mechanosensitive adherens junction proteins link actomyosin contractility to actin assembly using in vitro reconstitution.
Huge congrats to Aurélie Favarin, Rayan Said, & all authors!
In Science Advances: www.science.org/doi/10.1126/...
#actin #myosin #mechanobiology
This looks remarkable!! Building my favorite subcellular structure from the ground up--WOW!!
02.01.2026 12:33 — 👍 16 🔁 3 💬 0 📌 0
Scientists in the @alushinlab.bsky.social figured out how cells build a structure that lets them migrate. Unpacking these “finger-like” protein bundles that protrude from cells may lead to novel treatments for #metastasis. #RockefellerScience #YearInReview
🔗: https://bit.ly/3PKErmA
A 1.25 A!!! cryo EM structure of rubisco.
24.12.2025 11:15 — 👍 23 🔁 9 💬 0 📌 0
Join the Reck-Peterson lab in NYC as a HHMI Research Technician! This role will support our new work on the cell biology of secondary metabolite production in filamentous fungi. Apply here: hhmi.wd1.myworkdayjobs.com/en-US/Extern...
22.12.2025 14:10 — 👍 4 🔁 16 💬 0 📌 0
Final version is out! Our large-scale cryo-ET dataset 🔬 of Chlamydomonas reinhardtii 🦠 is now published in @cp-molcell.bsky.social
Huge collaborative effort! So glad to see the community already using it to develop new resources & tools.
Check it out here: shorturl.at/z4i4c
#CryoEM #CryoET
Organelles do NOT have a single uniform pH.
And if you think they must, because “protons diffuse fast,” this paper is for you.
A thread on why that assumption is wrong; and what we found instead. 🧵 1/n
The Reck-Peterson lab at Weill Cornell Medicine is seeking a technician or staff scientist to work on Aspergillus projects. Broad background in fungal biology and techniques required. Bioinformatics skills preferred. Find out more at: reckpetersonlab.org.
14.12.2025 16:28 — 👍 26 🔁 32 💬 2 📌 2
R35 MIRA NOFO
NIGMS R35 Maximizing Investigator's Research Award (MIRA) for Outstanding Investigators new NOFO is available!!
Submission dates starting in January 2026 through May 2028.
See link below: simpler.grants.gov/opportunity/...
Image of cell junction puncta from https://www.molbiolcell.org/doi/full/10.1091/mbc.E23-03-0077
To build the body plan of an animal, cells must adhere to one another via cell-cell junctions. We now know these assemble as punctate protein complexes containing thousands of proteins, but how this occurs remains mysterious. 1/n 🧪
www.molbiolcell.org/doi/full/10....
📢 Deadline approaching fast 📢
to submit an abstract for the great cytoskeleton extravaganza!
Structural Basis of Human Kinetochore-Microtubule Coupling by the Ndc80 and Ska Complexes https://www.biorxiv.org/content/10.64898/2025.12.06.692780v1
07.12.2025 23:46 — 👍 4 🔁 3 💬 0 📌 0
Happy to share our cryoEM Ensemble Optimization method! 🎉It infers optimal structures and their weights directly from individual cryoEM images - no maps just physics! with David Sliva-Sánchez, @erikhthiede.bsky.social & Roy Lederman www.biorxiv.org/content/10.6...
05.12.2025 16:13 — 👍 35 🔁 9 💬 1 📌 0
The decision by the Advisory Committee on Immunization Practices of the Centers for Disease Control and Prevention to downgrade its recommendations to protect infants from hepatitis B is a dangerous move that will harm children.
Click here to read AAP's full statement: bit.ly/3Y9ZQJT
