Prof Amanda J Farrin

I'm doing a webinar in two weeks (15 Oct 1-2pm BST), part of NIHR Research Support Service's Methods Academy series, on the age-old question: should I do a stepped wedge trial?

Free registration, details here: tinyurl.com/z6cjvce3

@nihr-rss.bsky.social @wiphcem.bsky.social @qmul-wiph.bsky.social

Great to have so many engaged people in the room!

More workshops are planned for 2026.

Follow us here and on LinkedIn find out about future training opportunities.

www.linkedin.com/company/ukcrc-registered-ctu-network/

#UKCTUNetwork #HTBAGCI #ClinicalTrials

Fern Harvey’s fab poster presentation of her systematic review on process evaluations for complex intervention trials. Better reporting of context, mechanisms of action and fidelity would enable greater learning about successful interventions #ImpSci #EIE2025 @au-primarycareuol.bsky.social

A cluster randomised crossover design incorporates the principles of both cluster trials (where groups of individuals eg wards, schools etc are randomly assigned) and crossover trials where, in this case, the clusters cross over to different treatment/s for set time periods 2/7

At #CCR25, we saw some trials use a #CompositeOutcome (an endpoint that combines more than one outcome into a single measure) & also saw some of the problems these can throw up. I have discussed these before but thought it would be useful to revisit 1/9
#MethodologyMonday #120

Flyer advertising a training course on How to be a great chief investigator for clinical trials. Find out more via the following link https://tinyurl.com/HTBAGCI

🚀 Exciting News! 🚀

Interested in or leading a clinical trial?

Want to be the best Chief Investigator you can be?

This updated course is for you!

tinyurl.com/HTBAGCI

#ClinicalTrials #CITraining

@leedsctru.bsky.social @amandafarrin.bsky.social

Phew: ResearchFish submitted again for another year ✅️

A common issue in trials is how to accommodate multiple important outcomes. Approaches include composite outcomes or using the win ratio method (I have posted on these before). A newer method is the #DOOR (Desirability of Outcome Ranking) approach 1/7 
#MethodologyMonday #113

📢 Delighted our CHART trial is now OPEN to recruitment

Massive effort from our @complexleedsctru.bsky.social trial team, @drandyclegg.bsky.social @vickigphysio.bsky.social & many others to get this complex study ready to go 🎉

🙏 @nihr.bsky.social for funding

Currently low response rates from CTU Directors (n=5), Programmers/Data Managers (n=0), & QA Managers (n=3) working in clinical trials. We need to know what these groups think the challenges are for greener trials.

forms.office.com/e/fkeLD8HbMA

Please complete &RT

@ukctunetwork.bsky.social

Consider what to report about your rehabilitation intervention? Here's a newly published TIDieR Rehab checklist
bmjopen.bmj.com/content/14/1...

Follow @freshstart-uk.bsky.social for all updates from our @leedsctru.bsky.social @nihr.bsky.social programme grant. We've just moved over to this platform 🙂

Another link to survey as initial link problematic for some - forms.office.com/e/fkeLD8HbMA

Do you work on clinical trials?

We need your help to understand the challenges to designing & delivering greener trials. Only 30 responses so far but we can all have a say on this topic. Please take 10 minutes to tell us what you think tinyurl.com/GreenTrials

Please share across your networks

Interesting historical principles of clinical trial conduct … Rule 5 “the medical statistician has to be competent” … sure hope we’ve got that one sorted!

An issue that often comes up is how to set a “non-inferiority margin” in a non-inferiority trial and how to ensure it is appropriate 1/8
#MethodologyMonday #109

Welcome to bluesky @complexleedsctru.bsky.social 🎉

Please do follow our Complex Interventions Division account for our news of our training opportunities, trial progress and results, as well as signposting to relevant resources for Complex Intervention trialists 👇

We've frustratingly allowed "real world" to become a deceptive synonym for "observations we happened haphazardly to make". I'd say half the studies that come to me now, the majority of which are useful but modest clinical audits, will have "real world" in the proposal title. It's magic!

Who’s quitting academia? Data reveal gender gaps in surprising fields Even in scientific areas in which women are well represented, they are up to 40% more likely than men to leave research within 20 years.

I am not that surprised that more women quit academic publishing than men- this chimes with data showing fewer women get their papers published, grants funded if they lead them and that more women get pushed into support roles. We do need to do more to support and mentor female staff. 🧪

Snow day

#Yorkshire
#Langsett

Reporting of cluster randomised crossover trials: extension of the CONSORT 2010 statement with explanation and elaboration This article presents the CONSORT (consolidated standards of reporting trials) extension for cluster randomised crossover trials. A cluster randomised crossover trial involves randomisation of groups ...

Want to know how to report a cluster-crossover trial … the CONSORT extension reporting guidance is out 😊
www.bmj.com/content/388/...

We're running our annual online Masterclass in Complex Interventions Evaluations over 3 days in January and February.

Come and learn from our expert team of complex interventions trialists at @leedsctru.bsky.social

Register now to reserve your place. Deadline 24 Jan.
Link below 👇

Just a wee bit of snow in Yorkshire 🥶❄️

🤢 horrifying piece of work, which we’ll see idiots quoting.
For goodness sake @jclinepi.bsky.social

Happy New Year!

May your 2025 be healthy, prosperous, and full of interesting research questions to explore!

Beautiful light from the late December sun in one of my favourite places today

#PeakDistrict
#LadyBower to #LostLad and back

Happy Boxing Day from a very sunny Yorkshire 😎🎄

Perfect temperature inversion around #EmleyMoorMast

With the approaching the start of the holidays please remember that HOW to ‘switch off’ is your thing. There’s no manual. Whatever suits you. Checking emails is not a crime during this time but it’s good practice -if you email back- to schedule sending for when the holiday is over.

Beautiful day for graduation 🎓 ceremony. So proud of Dr Sadia Ahmed: our 1st @mrcnihrtmrp.bsky.social PhD student to graduate from @leedsctru.bsky.social

Grateful for my co-supervisors @suzrich.bsky.social & Andy Clegg

And thank you for the beautiful flowers Sadia: but you did the hard work