Jason Yang

Steered generation for protein optimization: On datasets with ~10^2 measurements, steering a discrete diffusion model outperforms RL on a protein language model for generating improved variants.

@jsunn-y.bsky.social @francesarnold.bsky.social @yisongyue.bsky.social

arxiv.org/abs/2505.15093

22.05.2025 18:33 — 👍 27    🔁 4    💬 0    📌 0

Thank you to all of my co-authors: especially my co-lead, Ravi Lal, and advisors @yisongyue.bsky.social and @francesarnold.bsky.social!

16.01.2025 18:04 — 👍 0    🔁 0    💬 0    📌 0

x.com

Happy to share that our work on Active Learning-Assisted Directed Evolution is now published in @naturecomms.bsky.social!

Paper: www.nature.com/articles/s41...

Check out the original thread here: x.com/jsunn_y/stat...

16.01.2025 18:04 — 👍 15    🔁 3    💬 1    📌 0

Come visit our CARE benchmarks poster today at 11-2pm! (West Ballroom #5205)

13.12.2024 17:12 — 👍 4    🔁 1    💬 0    📌 0

I’m at NeurIPS this week presenting two of my recent projects!

Enzyme function classification (CARE) benchmarks: Friday 11-2pm West Ballroom #5205 @caltech.edu

Conditional generation from protein language models (ProCALM): Sunday at MLSB Workshop @Profluent

Please come say hi!

10.12.2024 20:24 — 👍 16    🔁 2    💬 0    📌 2