Martin Plöderl

Teurer als der Flug: Warum Bahnreisende oft draufzahlen Flugtickets quer durch Europa kosten oft weniger als ein Abendessen, während dieselbe Strecke mit dem Zug schnell ein Vielfaches kostet. Eine aktuelle Greenpeace-Analyse aus dem Jahr 2025 zeigt: Auf m...

On average, flying is cheaper than taking the train. About 50%.

Partly because there are less taxes on flights.

Absurd!

help.orf.at/stories/3234...

Crocus vernus - Wikispecies

Wild form of the Crocus Vernus
species.wikimedia.org/wiki/Crocus_...

Damit's nicht in Vergessenheit gerät ...

Robert F Kennedy Jr: 1 year of failure In his first speech as Secretary of the US Department of Health and Human Services (HHS), Robert F Kennedy Jr laid out a plan to restore trust. The COVID-19 pandemic saw public faith in Federal health...

"Politicians are known to break promises, but Kennedy's record, 1 year in, has been a failure by most measures, especially his own."

www.thelancet.com/journals/lan...

Ist übrigens eine wilde Form, der es scheinbar bei uns gefällt :-)

Wie effektiv sind Antidepressiva wirklich? Als der US-Psychologe Irving Kirsch im Jahr 2008 in der Fachzeitschrift Plos Medicine eine mittlerweile berühmte Studie veröffentlichte, erntete er Kritik

madindeutschland.org/wie-effektiv...

30 Jahre! 😱
Isn't it ironic?

Direkt vor unserem Haus :-)

Reason to commute to work by bike #87: stopping for a picture anytime ☺️

2. In the literature, the trial has been used to show that treatment with fluoxetine does not increase suicidality by some, and to show that fluoxetine increases suicide risk by others.

1. ITT vs. actually received treatment: important discussion which still needs to be done for the pediatric antidepressant (TADS) trial regarding rates of treatment emergent suicidality.
Fluoxetine vs. placebo: ITT: 15 vs. 11%, n.s.
Actually treated with fluoxetine: 11% vs. 2.7% (p < 0.02)

Five ways to spot when a paper is a fraud Science sleuths share their common-sense tips for sniffing out fishy articles.

Science sleuths share their common-sense tips for sniffing out fishy articles

go.nature.com/4ceKgVF

Agree. However, they found one significant interaction treatment x sex: a larger drug-placebo difference between men and women on day 2.
HTE? Ore more likely a false positive finding, given there were 4 subscales of the MADRS and 6 time points and no adjustment of alpha
pubpeer.com/publications...

Re-Analysis of three network meta-analyses of fluoxetine for depression in children and adolescents: clarifying efficacy and finding a zombie | RestoRes : Research integrity in biomedical research | O... Richard Lyus, Martin Plöderl and Florian Naudet will present how they discovered that a “zombie trial” can affect network meta-analyses and clinical guidelines on antidepressants for adolescents.

Tomorrow talk (hosted by University of Cambridge/CPFT Lunchtime Psychiatry Seminars) with R. Lyus and @ploederl.bsky.social will explore how a single “zombie” trial can meaningfully influence network meta-analyses and, in turn, shape clinical guidelines on antidepressant use in adolescents.

pubpeer.com/publications...

Thank you!

This is a great quote:

5-HTTLPR: A Pointed Review In 1996, some researchers discovered that depressed people often had an unusual version of the serotonin transporter gene 5-HTTLPR. The study became a psychiatric sensation, getting thousands of ci…

Reminds me of Border et al. (2019) on the serotonin transporter gene and this great blogpost: slatestarcodex.com/2019/05/07/5...
450 (!) preceding studies on the topic, most of them with a positive association. Then came Border et al.'s very large and well-conducted study reporting a null-finding.

Review on lithium: "lithium carbonate remains a first-line treatment for bipolar disorder, supported by robust evidence of ... reduction of suicide risk (Cipriani et al., 2013; Nabi et al., 2022,...).

However, we (Nabi et al.) reported that the evidence is inconclusive for suicides.

198 effect sizes in ego depletion resesrch showed an effect size of d=0.62. Preregistered large replications (including some by original authors) yielded an effect size of 0. No one has been able to offer any other explanation for this huge research waste than massive p-hacking.

Thanks for making so much work for me @mumumouse2.bsky.social 😡
5 papers with identical plots!
pubpeer.com/publications...

Can confirm. REDcap is good

an older man wearing glasses and a suit says " okay " Alt: An older man wearing glasses and a suit, looking concerned, says "okay"

Interesting start to the week:

Paper rejected with the justification that the journal does not accept pre-registrations or manuscripts that are based on pre-registrations 🤔🤪

#Registration #PreRegistration #RegisteredReport

Sex differences in placebo and antidepressant response to intranasal esketamine for treatment-resistant depression - Molecular Psychiatry Molecular Psychiatry - Sex differences in placebo and antidepressant response to intranasal esketamine for treatment-resistant depression

Precision psychiatry? Study on gender-specific esketamine response. Some gender diffs but irrespective of group (esk/placebo). Only one significant gender x treatment interaction, on a specific day, with a specific outcome: p = 0.02. It did not occur to authors that this is likely a false positive

*in* this review

bsky.app/profile/ploe...

Nice to see that on this review, our daylight saving time - suicide paper was the only one which was rated has being of high quality in all domains 😊

link.springer.com/article/10.1...

The strongest version of this illusion I’ve seen! Absolute head-wrecker!