Stef Schwartz

Another informative and exciting year at #KCRS with the Braun lab!

A fundraising page for Stephanie Schwartz Join the Closer to Free Ride on Saturday, September 6th. Register or donate at RideCloserToFree.org.

Excited to participate in the closer to free ride this year on team #CycloPaths! 100% of money raised goes to cancer research and patient care at Smilow Cancer Hospital and Yale Cancer Center.
#cancer #research #fundraising #yale

www.rideclosertofree.org/participant/...

Hardest workers out there

Vaccine experts band together to counter U.S. government misinformation Vaccine Integrity Project intends to provide scientific responses to ill-founded vaccine moves

Vaccine scientists and medical leaders have announced they are launching an unprecedented initiative to react to vaccine misinformation and scientifically unfounded vaccine decisions by the U.S. government. scim.ag/3ES9r1Q

Park, Sherwood et al. show that de novo lipid synthesis and polarized prenylation drives cell invasion through basement membrane rupress.org/jcb/article/...

📙 In our #Cancer Cell Biology collection: rupress.org/jcb/collecti...
#AACR25

Identification and characterization of cell niches in tissue from spatial omics data at single-cell resolution - Nature Communications Deciphering the features, structure, and functions of the cell niche in tissues remains a major challenge. Here, the authors develop scNiche, a computational framework to identify and characterise cel...

Braun lab April journal club article.

A very rad and novel method to identify cell niches.

Hell ya New Haven!

Mapping single-cell transcriptomes in the intra-tumoral and associated territories of kidney cancer Tumor behavior is intricately dependent on the oncogenic properties of cancer cells and their multi-cellular interactions. To understand these depende…

Braun lab March journal club.

The authors identify IL1B, expressed by a subset of TR Macs, may potentially promote tumor cell EMT via single-cell and spatial transcriptomics.

Tempting.

HIF regulates multiple translated endogenous retroviruses: Implications for cancer immunotherapy An upregulation of the HIF2 transcription factor, which is a hallmark of the most common form of human kidney cancer, drives the expression of multiple relatively intact endogenous retroviruses, inclu...

ERVs in RCC.

Review @annualreviews.bsky.social @lucasite-lab.bsky.social
Decoding Immunobiology Through Genetic Errors of Immunity
www.annualreviews.org/content/jour...

An oldie but goodie.

This is outstanding! Watch it and share...

Finally…

Alzheimer’s scientist resigns after university finds ‘data integrity concerns’ in papers University of Minnesota’s Sylvain Lesné was at the heart of an image-doctoring scandal on study of key amyloid protein linked to dementia

Alzheimer’s scientist resigns after university finds ‘data integrity concerns’ in papers | Science | AAAS www.science.org/content/arti...

Report: Every dollar of NIH research funding doubles in economic returns Research funded by the National Institutes of Health (NIH) generated $2.46 in economic activity for every $1 of funding in 2023, a total of $92.9 billion, according to an

www.fiercebiotech.com/research/rep...

What can we do?

HHMI kills program aimed at boosting inclusivity in STEM education “Inclusive excellence” program had committed $60 million to 104 institutions

The Howard Hughes Medical Institute, the nation’s largest private funder of biomedical research, yesterday killed a $60 million program aimed at making universities’ STEM education more inclusive. scim.ag/3EtS0US

Successful anti-cancer immune responses reported in phase 1 trial of a personalized cancer vaccine for #kidneycancer. Research in Nature led by @drchoueiri.bsky.social #PatrickOtt #CatherineWu #DerinKeskin (all of @danafarber.bsky.social) and David Braun of @yalecancer.bsky.social. bit.ly/3CDIT3n

A personalized cancer vaccine to prevent the return of high-risk kidney cancer A phase I clinical trial supports the safety and feasibility of a vaccine to limit disease recurrence in people with kidney cancer.

A personalized cancer vaccine to prevent the return of high-risk kidney cancer @nature.com @braunmdphd.bsky.social
@drchoueiri.bsky.social
www.nature.com/articles/d41...
www.nature.com/articles/s41...

Man I wish my last name was Kennedy. Maybe I would get to run the Department of Transportation. My qualifications are driving a car sometimes and advocating for seatbelt use.

Is the HPV Vaccine Safe? Yes, Despite What R.F.K. Jr. Has Said. During his second day of confirmation hearings, Robert F. Kennedy Jr. declined to disavow comments he had made disparaging the vaccine as unsafe.

Yes, the HPV vaccine is safe, despite R.F.K. Jr.'s claims. It's remarkably effective at preventing cancer — roughly 97% effective in preventing cervical cancer, and nearly 100% effective in preventing external genital warts.

Scientists flock to DeepSeek: how they’re using the blockbuster AI model Researchers are testing how well the open model can perform scientific tasks — in topics from mathematics to cognitive neuroscience.

DeepSeek's open AI model is giving scientists worldwide the opportunity to train custom reasoning models designed to solve problems in their disciplines.


https://go.nature.com/4azXz07

Deep learning enhances the prediction of HLA class I-presented CD8+ T cell epitopes in foreign pathogens - Nature Machine Intelligence Accurate prediction of immunogenic CD8+ T cell epitopes would greatly accelerate T cell vaccine development. A new deep learning model, MUNIS, can rapidly identify HLA-binding, immunogenic and immunod...

Deep learning enhances the prediction of HLA class I-presented CD8+ T cell epitopes in foreign pathogens
www.nature.com/articles/s42...
@natmachintell.bsky.social

Devotees of Mt. Bachelor Ski Area Are Working to Take Their Mountain Back Devotees of Mt. Bachelor are putting together a bid to rescue the ski area — and their way of life — from the titans of the industry.

Awesome old school vibe resort. Lucky to have skied it this season.

Ride or die Kirkland 😎

JAMA Patient Page

Renal cell carcinoma is a common cancer that forms in the kidneys.

This JAMA Patient Page describes renal cell carcinoma and its risk factors, signs and symptoms, treatment, and prognosis.

ja.ma/4jHvhoH

#MedSky

Costco is the best. Kirkland for lifeee

All NIH study sections canceled indefinitely. This will halt science and devastate research budgets in universities.