Quentin Frenger

Functional and Morphological Plasticity of the Endolysosomal System: Pigment Organelles at the Crossroads of Physiology and Pathology The morphodynamical plasticity of the endolysosomal system supports the formation and function of specialized intracellular compartments, as exemplified by the pigment organelles in skin cells. In ep....

onlinelibrary.wiley.com/doi/10.1111/...

Check out our last review on endolysosomal plasticity in pigment organelles biology by @laurasalavessa.bsky.social @delevoyecedric.bsky.social in @biologyofthecell.bsky.social !

What a truly beautiful time at the European Intermediate Filament Meeting 2025 in Lyon! I was so glad to meet such a welcoming community.

I'm honored to have won the Best Oral Communication Prize for my recent postdoc project on Vimentin and Autophagy!

Huge thanks to the organizers!

New paper alert! I’m very excited to share our paper published in @embojournal.org! @pdc-lab.bsky.social @yaleneuro.bsky.social

CLEM-Reg: an automated point cloud-based registration algorithm for volume correlative light and electron microscopy - Nature Methods CLEM-Reg automates the three-dimensional alignment of volume correlative light and electron microscopy datasets by leveraging probabilistic point cloud registration techniques for fast and accurate re...

Super happy to see CLEM-Reg out in @natmethods.nature.com! A short thread on the algorithm behind it and how to try it out for yourself🧵(1/9)

www.nature.com/articles/s41...

A conserved ion channel function of STING mediates noncanonical autophagy and cell death | EMBO reports imageimageActivated STING forms a highly conserved proton channel which deacidifies post-Golgi STING trafficking vesicles. The channel of STING is essential for noncanonical functions of the cGAS pathway, such as ATG8 lipidation onto single ...

Jay Xiaojun Tan's group was also involved in the STING proton channel saga.
www.embopress.org/doi/full/10....

LYVAC/PDZD8 is a lysosomal vacuolator Lysosomal vacuolation is commonly found in many pathophysiological conditions, but its molecular mechanisms and functions remain largely unknown. Here, we show that the endoplasmic reticulum (ER)–anch...

www.science.org/doi/10.1126/...
Important study!
Authors identify PDZD8 (renamed LYVAC) as an ER-anchored lipid transfer protein.
In response to lysosomal osmotic stress, it provides lipids to support lysosome swelling.
Unlike ATG2, LYVAC does not supply lipids to damaged lysosomes.

EBV induces CNS homing of B cells attracting inflammatory T cells - Nature Epstein–Barr virus infection generates a neuroinvasive B cell subset, which recruits activated T cells to the central nervous system, promoting multiple sclerosis.

www.nature.com/articles/s41...
EBV-expanded B cells home to the CNS where they attract T cells, mainly via CXCR3 expression, to trigger multiple sclerosis.
Congrats to the authors !

Lysosomal membrane homeostasis and its importance in physiology and disease Nature Reviews Molecular Cell Biology, Published online: 04 August 2025; doi:10.1038/s41580-025-00873-wLysosomes degrade cellular components, and their membrane is an important signalling hub. Recent insights into the mechanisms that maintain lysosomal membrane homeostasis — including the interplay between membrane damage, repair, lysophagy and lysosome biogenesis — highlight their importance in physiology, in disease and during ageing.

New Online! Lysosomal membrane homeostasis and its importance in physiology and disease

Sad days.
www.pnas.org/doi/full/10....
www.nature.com/articles/s41...

🙏🙏🙏

You know it's going to be good when it says 'ATG16L1-dependent'😜!
Congrats on the great work @carlaalemany.bsky.social, @julianedagraca.bsky.social !!!

ER-endosome contacts generate a local environment promoting phagophore formation Da Graça et al. identify ER-endosome contact sites as critical hubs for autophagosome biogenesis, where starvation triggers sequential endosome tethering to ER exit sites. This spatiotemporal coordina...

FINALLY OUT ! After a long journey (of PhD and publication process) my paper on the role of ER-endosomes contact sites in autophagosome formation is officially out 🥳🥳 www.cell.com/cell-reports...

🎉 Congratulations to @julianedagraca.bsky.social, recipient of the 2025 Beth Levine #ThesisPrize! Her outstanding research @membramics-lab.bsky.social on the role of ER/Endosome contact sites in the regulation of #autophagy captures the award's spirit of excellence and innovation. 👏

dear all! The Membrane Band (www.membraneband.com) will give a concert for the 30th Anniversary of the "Cell biology & Cancer Research Unit" (aka UMR144 for close friends) ‪of Curie Institute on Monday 23th fo June! @institutcurie.bsky.social

see you there?

Our Immune Cell Biology collection emphasizes cellular dynamics, immune regulation, and disease mechanisms. Explore research on the mechanisms of dendritic cell regulation, T cell migration, neutrophil spreading and macrophage motility in tumor invasion, & more: rupress.org/jcb/collecti...
#AAI2025

Quiescent cell re-entry is limited by macroautophagy-induced lysosomal damage Lysosomes are damaged in quiescent cells, and UPR regulators, IRE-1/XBP-1, promote lysosome repair for cell-cycle re-entry. Lysosome damage in quiescent cells is caused in part by macroautophagy and i...

Quiescent cell re-entry is limited by macroautophagy-induced lysosomal damage: Cell www.cell.com/cell/fulltex...

Thank you!!

Thank you !! ☺️

Thank you Cédric !

The prizes for best presentations went to Léa Ripoll for her work on adenylate cyclase and dopamine signalling in neurons and Quentin Frenger for his work on ATG16L1 and B cell antigen receptor trafficking. Congratulations !!

Thanks again to my supervisor Fréderic Gros and everyone that supported me along this journey!Thanks also to the @membramics-lab.bsky.social lab, which I'm very proud to have joined as a postdoc!

I was very happy to present part of my thesis work at the 27th @clubexo-endo.bsky.social meeting and to win one of the prizes for the best oral communication! It was an excellent meeting packed with friendly people doing amazing science!

It was indeed a fantastic talk !

The V-ATPase/ATG16L1 axis drives membrane remodeling during epithelial morphogenesis Epithelial tubulogenesis shapes internal organs by transforming flat epithelial sheets or unpolarized cords into hollow tubes with central lumens. A key example is the formation of the posterior neura...

The V-ATPase/ATG16L1 axis drives membrane remodeling during epithelial morphogenesis www.biorxiv.org/content/10.1...

New lab preprint! Unveiling the Molecular Architecture of T Cells and Immune Synapses with Cryo-Expansion Microscopy (Cryo-ExM). A fantastic collaboration with Dr. Benita Wolf. Congratulations to all authors, especially Florent Lemaitre, for leading this amazing work! www.biorxiv.org/content/10.1...

The microtubules of a B cell (magenta hot) relocalize upon recognition of an antigen (green) by the BCR.

At this level, it's witchcraft!
Congrats !

Happy to officially introduce FilaBuster - a strategy for rapid, light-mediated intermediate filament disassembly. Compatible with multiple IF types, modular in design, and precise enough to induce localized filament disassembly in live cells.

www.biorxiv.org/content/10.1...

We dedicated this paper to Michel Bornens who passed away 3 years ago. He would have enjoyed this movie so much!

The bridge-like lipid transport protein VPS13C/PARK23 mediates ER–lysosome contacts following lysosome damage Nature Cell Biology - Wang et al. show the recruitment of the lipid channel protein VPS13C and formation of VPS13C-dependent contacts between endoplasmic reticulum and lysosomes after lysosomal...

"The bridge-like lipid transport protein VPS13C/PARK23 mediates ER–lysosome contacts following lysosome damage" out now in Nature Cell Biology
rdcu.be/ehbaL