Lisa Beutler

How many 50s of millions do you reckon you’re owed?

Thank you! I initially got interested in this in part because I’ve had IBD since I was a kid. Appetite loss is an early indicator of flares and it has fascinated and frustrated me for as long as I can remember :)

New work from the lab on how sickness reduces appetite. Turns out, it’s complicated :)

We focused on a single inflammatory cytokine, IL-1b, and even that reduces appetite via multiple mechanism.

Thanks to Nik Hayes for leading and sticking with this project and to everyone else who contributed!

Not gonna lie: I cried a little.

YES!!!!

To summarize:

Most important

Max Perutz was NOT an example of someone with a great idea who went against the establishment wisdom to solve an important problem that he had uniquely identified.

He was part of an organized team working on this problem. He got lots of help.

11/14

Previously shared: GLP-1 physiology and pharmacology along the gut-brain axis

This Review by @lbeutler.bsky.social summarizes proposed gut-brain and central mechanisms through which GLP-1 and its synthetic analogs regulate food intake and bodyweight: doi.org/10.1172/JCI194744

I learned and synthesized a lot writing this review for @jci.org and hope it helps others do the same.

GLP-1 physiology and pharmacology along the gut-brain axis

This Review by @lbeutler.bsky.social summarizes proposed gut-brain and central mechanisms through which GLP-1 and its synthetic analogs regulate food intake and bodyweight: doi.org/10.1172/JCI1...

This Little-Known Appeal Could Force Your Insurer to Pay for Lifesaving Care. Here’s How to File It. When a health insurer refuses to pay for your treatment, you may have the right to have the denial reviewed — and potentially overturned — by an independent provider. Here are six steps experts sugges...

Few patients appeal a health insurance denial, but a little-known process that requires insurers and plans to seek an independent opinion can force insurers to pay for what can be lifesaving treatment.

Here’s what experts say you need to know.

Thrilled to be accepted to @acnporg.bsky.social @npp-journal.bsky.social and look forward to future meetings!

Congrats to all new members!

Also, an annual reminder to keep applying if you didn't make the cut at #ACNP2026.

You’re doing better than me! I haven’t gotten past the error screen at login 😂. Guess I wasn’t meant to do this today.

Happy birthday/anniversary/new year!! Our party animals didn’t even make it to 9pm

Fighting for Breath: The FDA’s Lax Generic Drug Rules Put Her Life at Risk Lung transplant patient Hannah Goetz’s life depended on the generic version of the critical drug tacrolimus. It was supposed to be equivalent to the brand-name medication — but the FDA doesn’t always ...

When Hannah’s pharmacy began filling her tacrolimus prescription with a generic version, the lung transplant patient didn't know something very important:

Months earlier, an FDA-commissioned study concluded that this generic was not equivalent to the brand drug -- and that her life was at risk.

Only worse when you could’ve walked to your destination in like 30 min

Good luck! ❤️

Beautiful work! Congrats to all!

The one tidbit of unambiguously good news I heard about study section today is that it is moving back to zoom from teams.

Opinion | Cancer Patients Like Me Are Casualties of MAHA’s Hypocrisy

So proud of my dear friend Sam for writing this. So furious he has to go through it.

www.nytimes.com/2025/11/11/o...

Schumer and the Dems are about to teach Trump the lesson that they’ll cave whenever he abuses power to sufficiently hurt people.

ICE Abduction Inside Daycare: Press Conference YouTube video by U.S. Representative Mike Quigley

This morning, ICE unlawfully kidnapped a day care worker in front of parents and children.

We’re demanding accountability for every way that DHS is violating our rights, breaking the law, and acting with impunity. We must resist.

WATCH.

ICE isn’t going after the worst of the worst. This morning, they took a preschool teacher without a warrant IN FRONT OF CHILDREN in my district.

#ice #chicago

Along with everything else, Trump admitting the shutdown led to a bloodbath for Republicans should at an absolute minimum lead Dem Senators to shelve their apparent plan to prematurely cave. He's admitting he and the GOP are in a weak position, Dems. Exploit that!

25 Thoughts About The 2025 Elections Fighting is winning, and now would be a crazy time to pull punches.

21 more at the link… www.offmessage.net/p/25-thought...

Go blue.

Is this ‘the compact’ or is this something else? Not clear to me from anything I’ve seen so far

Your dryness is its own reward

We just tried to get a blue line at Chicago. There was a train-full worth of people waiting on the platform and a completely full train pulled up. We are taking a bus now, which is also full of people headed to #NoKings

Crowd trying to get on cta train for no kings protest.

People waiting for cta train in chicago. Tee shirts read’ immigrants make America great’

So many people heading to the #NoKings protest in Chicago that it’s standing room only on the train. In fact, it’s so packed we can’t get on this one.

My favorite part is the Freddie Freeman reaction shot 😂