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Scott Canna

@cannalab.bsky.social

Auto- & Hyper-inflammation | MAS HLH | IL-18 | It's all Immune Dysregulation | Gettin’ down wit OPD | ❀️er of puns | 🚲 evangelist | opinions my own labcanna.org

92 Followers  |  175 Following  |  18 Posts  |  Joined: 11.03.2025  |  1.7181

Latest posts by cannalab.bsky.social on Bluesky

Espinosa Lab

#HLH, #Trisomy21, immune dysregulation ...

Case conf webinar featuring:
*** Joaquin Espinosa (espinosalab.org) ***

Thursday 13 November, 11AM ET

Register at
us02web.zoom.us/webinar/regi...

@clinimmsoc.bsky.social

16.10.2025 23:02 β€” πŸ‘ 2    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
Quote graphic that reads "We are gravely concerned that American people will needlessly suffer and die as a result of policies that turn away from sound interventions. After careful consideration, we insist on Kennedy’s resignation to restore the integrity, credibility and science-driven mission of HHS and all its agencies." with AAI logo

Quote graphic that reads "We are gravely concerned that American people will needlessly suffer and die as a result of policies that turn away from sound interventions. After careful consideration, we insist on Kennedy’s resignation to restore the integrity, credibility and science-driven mission of HHS and all its agencies." with AAI logo

We have joined @idsainfo.bsky.social, @asm.org, and 19 other medical, scientific, public health and patient organizations, in calling for the resignation of HHS Secretary Robert F. Kennedy Jr., to ensure the health of the American people.

Read the statement in full: news.aai.org/2025/09/04/j...

04.09.2025 16:45 β€” πŸ‘ 15    πŸ” 3    πŸ’¬ 0    πŸ“Œ 1
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Too bad that the timelapse we made of an activated CTL (green, Ca++ flux) and contracting BMDC (red/PI) was too low-res for the cover.

31.07.2025 21:30 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
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Thx @bloodjournals.hematology.org editors for highlighting our work (led by AFKamenetskii) on the
HLH Immune Synapse
doi.org/10.1182/bloo...

Thx also to Drs. Machowicz & La Rosee for their editorial
"HLH: it is all about communication" doi.org/10.1182/bloo...

31.07.2025 21:30 β€” πŸ‘ 2    πŸ” 0    πŸ’¬ 2    πŸ“Œ 0

When β€œowning the libs” means turning your back on the most successful humanitarian act ever (vaccination), I’m grateful for an AAP with the courage and knowledge to step up.

25.06.2025 23:07 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
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Insights from the 2024 pediatric rheumatology basic/translational years in review - Pediatric Rheumatology Background Advances in Pediatric Rheumatology are driven by mechanistic insights from basic and translational science. We have selected and reviewed the most impactful basic/translational science from...

Fun writing "Insights from the 2024 ACR/PRES Peds Basic/Translational YIR" with the talented Dr. Jessica Turnier @umich.edu.

My 1st time citing @glaucomflecken.bsky.social ... so far.

link.springer.com/article/10.1...

23.05.2025 13:22 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0

Drs. Manson & Tattersall have led a UK-wide effort to bring consistent, excellent #HLH care to their institutions & the broader @england.nhs.uk ... & tracking their outcomes.
Please register: us02web.zoom.us/webinar/regi...

20.05.2025 21:55 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0

Histiocyte Society #HLH Webinar

"Multi-disciplinary Approach to Managing HLH"

Headlined by @racheltattersall.bsky.social and Jessica Manson, @ucl.ac.uk who've really brought HLH excellences to @england.nhs.uk

July 24th, 11AM NY/8AM SF/4PM UK/5PM CET

Details and link are forthcoming

14.05.2025 14:15 β€” πŸ‘ 5    πŸ” 5    πŸ’¬ 0    πŸ“Œ 1
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"Modeling the #HLH immune synapse uncovers critical roles for IS termination, cytokine intensity, and target cell death"

We're pretty excited about this one.

doi.org/10.1182/bloo...

13.05.2025 21:54 β€” πŸ‘ 3    πŸ” 3    πŸ’¬ 0    πŸ“Œ 0
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It takes a special talent to observe the phenotype of an ETS1 super-enhancer deletion and see into the evolution of paralogous transcription factors.

Holy 🀯, @vahedilab.bsky.social!

06.05.2025 21:36 β€” πŸ‘ 6    πŸ” 1    πŸ’¬ 1    πŸ“Œ 0
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When you love bicycles AND immunology, you gotta share it with like-minded friends. Beautiful AM ride through Belmont Plateau here in Philly with Drs. Hoffman & Platt. #CIS2025.

03.05.2025 14:34 β€” πŸ‘ 5    πŸ” 0    πŸ’¬ 1    πŸ“Œ 0
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@autoinflammatory.bsky.social, @rashmi.bsky.social,
If you have a Still's problem,
if no one else can help,
and if you can find a lab to run it
maybe you can test for ...

01.05.2025 14:35 β€” πŸ‘ 2    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
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A #STAT1 #STAT3 master class from Alejandro Villarino
@upenn.edu IGG.

29.04.2025 20:48 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
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Crazy for Americans to be talking about IL-18 in Japan, but luckily @grantschulert.bsky.social already warmed up the crowd.

26.04.2025 07:21 β€” πŸ‘ 5    πŸ” 1    πŸ’¬ 0    πŸ“Œ 0

Next: Dr. Nishikomori (Kurume) - stability of somatic NLRP3 VAF in early vs. late-onset somatic NLRP3, capitalizing on πŸ‡―πŸ‡΅ tradition of keeping dried umbilic cord!!

Why in somatic CAPS does phenotype match genotype, not VAF? NOMID variant in 5% = NOMID, not FCAS?!
@autoinflammatory.bsky.social

26.04.2025 06:28 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0

Having a great time at Japan College of Rheumatology meeting, Fukuoka.

Most recent head-explosion, new story from the JJ Chae wing of the Kastner machine: Cofilin-1 senses ROS by auto-inhibiting under oxidative conditions and releasing NLRP3.

26.04.2025 06:01 β€” πŸ‘ 3    πŸ” 1    πŸ’¬ 1    πŸ“Œ 0
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Help support Children's Hospital of Philadelphia (CHOP) The 31-Day Challenge is a virtual event that encourages you to get active during the 31 days of May, and fundraise to help kids at CHOP. Join me!

This May, please consider bike commuting. Please also consider supporting @chopresearch.bsky.social

chop.donordrive.com/index.cfm?fu...

08.04.2025 08:06 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
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Trump administration purges U.S. health agency leaders Reassignment letters come as reductions in force begin at NIH, FDA, and CDC

Power-plays aside, this (science.org/content/arti...) is short-sighted

The backlash is building. It will insist on protecting NIH from future reckless sabotage. It will make NIH even more resistant to reform.

01.04.2025 18:54 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
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Playing an β€œice breaker” game … the best possible prompt.

26.03.2025 15:38 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0

@cannalab is following 19 prominent accounts