LKB1 (STK11)

❄️☕👩🏻‍💻

Proanthocyanidins enhance antitumor immunity by promoting ubiquitin-proteasomal PD-L1 degradation via stabilization of #LKB1 and SYVN1 www.jci.org/articles/vie...

🔥 Hot paper from new investigators reveals that LKB1 mono- and bi-allelic loss increasingly reprograms the intestinal epithelium into a regenerative state characterized by autocrine EGF signaling and a predisposition towards serrated #ColorectalCancer development.
🔗 https://ow.ly/aXBj50Yfhem

This week's cover @thelancet.com

CIHR funding rate: 13.6%.
Early 2000s: 30%+.

Canada’s new $1.7B Impact+ program recruits talent — but without increased Tri-Council base funding, we risk further strain on an already stretched system.

We’re calling for $1B over 5 years.
Support here: tinyurl.com/33c5av46

15% of LUAD lacked TTF-1 expression
-> lower PD-L1 & more frequent KRAS and high-risk mutations, such as STK11, KEAP1, & SMARCA4
-> TTF-1 negativity stratified outcomes even among pts with high-risk mutations

What is your University internal deadline like? Single deadline or double deadline?
-CIHR LOI date Feb 4, 2026
-Dalhousie FoM internal deadline on Uni server Feb 12, 2026
-Dalhousie ORS internal deadline on Uni server & ResearchNet Feb 17, 2026
CIHR Deadline Mar 4, 2016 @dalhousieu.bsky.social

Proanthocyanidins enhance antitumor immunity by promoting ubiquitin-proteasomal PD-L1 degradation via stabilization of LKB1 and SYVN1 @jci.org
www.jci.org/articles/vie...

This preprint maps synthetic lethal (SL) targets across 15 common cancer drivers using genome-wide CRISPR KO screens in isogenic cell line pairs plus a large-scale comparison to DepMap.

www.biorxiv.org/content/10.6...

What if “undruggable” cancer drivers are druggable indirectly?

New bioRxiv preprint: 15 CRISPR synthetic lethality screens + DepMap, then validation with clonogenic assays counted on GelCount.

ARID1A→GFPT1, STK11→MARK2, FBXW7→PKMYT1.

Read here: www.biorxiv.org/content/10.6...

Obesity disrupts ILC2 metabolic and functional homeostasis by inhibiting mTORC1 signaling - Cellular & Molecular Immunology Cellular & Molecular Immunology - Obesity disrupts ILC2 metabolic and functional homeostasis by inhibiting mTORC1 signaling

🔒📚
www.nature.com/articles/s41...

Vibe Coding Omics Data Analysis Applications Building custom data analysis platforms has traditionally required extensive software engineering expertise, limiting access for many researchers. Here, I demonstrate that modern large language models...

Well, I don’t know what to say here. Discuss…

@cashwood.proteaglyco.com

pubs.acs.org/doi/10.1021/...

CRISPR screens in iPSC-derived neurons reveal principles of tau proteostasis CRISPR screens in iPSC-derived neurons reveal that the E3 ubiquitin ligase CRL5SOCS4 ubiquitinates tau, that CUL5 expression is correlated with resilience in human Alzheimer’s disease, and that electr...

After a long review process, I'm excited that our paper is finally in print: www.cell.com/cell/fulltex...

TL;DR: We use CRISPR screens in iPSC-derived neurons to find a new tau E3 ligase and a relationship between oxidative stress, the proteasome, and tau proteolytic fragments.

More below 👇

A targeted combination therapy achieves effective pancreatic cancer regression and prevents tumor resistance | PNAS Pancreatic ductal adenocarcinoma (PDAC) has one of the lowest cancer survival rates. Recent studies using RAS inhibitors have opened the door to mo...

As generalized before, most cancer promoting genes are enriched in embryonic neural/neural stemness cells, incl. KRAS/HER2/EGFR/STAT3.
They confer cancer cell with neural stemness, which determines tumorigenicity&pluripotency in cells. @pnas.org

www.pnas.org/doi/10.1073/...

STK11 mutations and deletions define a distinct subtype of cervical adenocarcinoma https://www.medrxiv.org/content/10.64898/2026.01.01.25343162v1

👀 "LKB1 acts as a nexus between metabolism and gene expression, acting via the SMARCA4-SWI/SNF complex to regulate gene expression in lung cancer."

New preprint out of Marignani Lab
@pmarignani.bsky.social

Tumour suppressors LKB1 and SMARCA4 functionally interact to regulate gene expression of diverse biological processes in lung cancer https://www.biorxiv.org/content/10.64898/2026.01.26.699134v1

AI disruptions reveal the folly of clinging to an idealized modern university Alternative educational movements offer insights about how to help university students find purpose and hope as they navigate an increasingly complex world.

theconversation.com/ai-disruptio...

The knowledge factory model is outdated and ill-suited to meaningful learning. In this form of education, generative AI technologies will increasingly outperform students.

This review examines the roles of #LKB1/STK11 in #cancer, detailing its #TumorSuppressive functions, regulation via #AMPK signaling and #AdaptorProteins, and discusses the challenges of developing LKB1-targeted inhibitors. @westernu.bsky.social

#OpenAccess: doi.org/10.1016/j.ge...

Critical role for a high-plasticity cell state in lung cancer @nature.com @mskcancercenter.bsky.social
www.nature.com/articles/s41...

When science discourages correction: How publishers profit from mistakes Academic publishing system often allows scientific errors to persist because it prioritises profit and prestige over timely correction.

Academic publishing is now one of the most lucrative industries per unit of input

theconversation.com/when-science...

Single-cell RNA-seq is younger than the iPhone. 🤯 The first bona fide scRNA-seq transcriptomes were published in 2009 by Tang et al., who sequenced individual mouse cells and showed you could capture a whole transcriptome from a single cell. From “sci-fi” to standard tool in just over a decade...

From "The Tumor Suppressor Kinase LKB1: Metabolic Nexus" by Mohammed Bourouh, Paola A. Marignani. HIF1α promotes expression of glycolytic enzymes. Schematic representation of glycolysis and the pentose phosphate pathway (PPP). LKB1 phosphorylates and activates AMPK which then phosphorylates and inhibits RAPTOR, thereby inhibiting mTORC1. mTORC1 promotes HIF1α upregulation. Active HIF1α promotes expression of glycolytic enzymes (red) increasing glycolysis rate. HIF1α also promotes expression of 6PGD to shunt glucose-6-phosphate to the PPP to generate NADPH for REDOX balance and for synthesis of ribose-5-phosphate for nucleotide synthesis.

www.frontiersin.org/journals/cel...

Review: "The Tumor Suppressor Kinase LKB1: Metabolic Nexus"

LKB1 loss is associated with multiple malignancies and causes metabolic reprograming to increase glycolysis and lactate production, elevate hexosamine biosynthesis and glutamine metabolism.

Regulation of cell surface protease receptor S100A10 by retinoic acid therapy in acute promyelocytic leukemia (APL)☆ - Cell Death & Disease Cell Death & Disease - Regulation of cell surface protease receptor S100A10 by retinoic acid therapy in acute promyelocytic leukemia (APL)☆

www.nature.com/articles/s41...

Holloway et al. reveal that adaptor protein p11 is rapidly turned over by the proteasome and that its stability is tightly controlled through both ubiquitin-dependent and ubiquitin-independent mechanisms.

🔬New Preprint Alert 🔬 How is AMPK regulated by oxidative stress? We use functional imaging to uncover spatial regulation of AMPK activity during oxidative stress by LKB1 & CaMKK2. Combining imaging with proteomics & metabolomics, we find AMPK works to promote the cellular redox response.

A Comprehensive Mutational and Histopathological Analysis of STK11-Mutant Non-Small Cell Lung Carcinomas Despite recent advances in the understanding of genomic and immunopathologic mechanisms of lung cancer, this disease remains the leading cause of canc…

Whoopsie, malformed link.

www.sciencedirect.com/science/arti...

www.sciencedirect.com/science/arti...

Authors combined targeted NGS with STAS and LVI scoring and organ-specific metastasis profiling within a single well-defined NSCLC cohort. This design allows them to directly link #STK11 mutation subtypes with distinct clinical and metastatic phenotypes. #LKB1

The authors also show in vivo protection against IgE-mediated anaphylaxis, hinting that AMPK agonists could be a real therapeutic avenue.

What’s striking is how zingerone works. By boosting LKB1/AMPK signaling, it reins in mast cell activation at the source, lowering Ca²⁺ influx, reducing granule release, and dampening the whole allergic cascade. It’s a metabolic lever with immunological consequences.

www.mdpi.com/1467-3045/47...

Zingerone, a ginger-derived compound, activates the LKB1/AMPK pathway to block IgE/FcεRI-dependent mast cell degranulation and anaphylaxis in models. Highlights AMPK agonists as potential anti-allergic therapeutics.