Adam Marblestone

YouTube video by Simons Foundation Nicole Rust - The representation of mood in the primate insula (May 6, 2025)

Please spread the word! I am recruiting a PhD student this cycle (Fall 2026 start) to join my team in a new venture: the neuroscience of mood.

If you are curious to learn more, this short talk provides a good overview of why, what and how.

www.youtube.com/watch?v=gjIK...

Bright green transparent metal-organic framework crystals prepared with copper and a “multipronged” carboxylic acid ligand. The crystals formed blocky roughly rectangular pieces with some very large emerald-like chunks.

Pink/red transparent metal-organic framework crystals prepared with cobalt and a “multipronged” carboxylic acid ligand. The crystals formed as a mixture of long rectangular types and aggregated chunks.

Purple transparent metal-organic framework crystals prepared with cobalt and a “multipronged” carboxylic acid ligand. The crystals formed long slightly blocky needles.

Clear transparent metal-organic framework crystals prepared with zirconium and a “multipronged” carboxylic acid ligand. The crystals formed chunky hexagons.

I don’t think I’ve ever had more fun in the lab than when I was making MOFs myself (and trying to use them for small-molecule X-ray structure determination). So let me celebrate by posting a few of the MOF crystals I prepared:

Say what? 👍

Bridging Systems: Open Problems for Countering Destructive Divisiveness across Ranking, Recommenders, and Governance Divisiveness appears to be increasing in much of the world, leading to concern about political violence and a decreasing capacity to collaboratively address large-scale societal challenges. In this wo...

Soooooo when is bluesky deploying bridging systems
arxiv.org/abs/2301.09976

Hidden networks in the brain Dendritic nanotubes extend brain connectivity beyond synapses

I love these new layers of complexity that people are discovering in the brain! Dendrites of different neurons can connect via nanotubes, which transport calcium and cargo such as amyloid-beta www.science.org/doi/10.1126/...

Lead by postdoc in the lab Ruiqi Ge and in collaboration with Bob Coffey’s lab, we are happy to share rPAL-seq for rapid and sensitive sequencing based profiling of glycoRNAs @biorxivpreprint.bsky.social www.biorxiv.org/content/10.1...

Male CNS Connectome A team of researchers has unveiled the complete connectome of a male fruit fly central nervous system —a seamless map of all the neurons in the brain and nerve cord of a single male fruit fly and the ...

Exciting news for #drosophila #connectomics and #neuroscience enthusiasts: the Drosophila male central nervous system connectome is now live for exploration. Find out more at the landing page hosted by our Janelia FlyEM collaborators www.janelia.org/project-team....

Minimally invasive implantation of scalable high-density cortical microelectrode arrays for multimodal neural decoding and stimulation - Nature Biomedical Engineering A 1,024-channel microelectrode array is delivered to the brain cortex via a minimally invasive incision in the skull and dura, and allows recording, stimulation and neural decoding across large portions of the brain in porcine models and human neurosurgical patients.

Precision Neuroscience published their high-density ECoG in Nature Biomed. Eng.

The startup shows a 1,024-channel grid implanted through a cortical slit in pigs, and intraoperative neural recordings and stimulation in five humans at sub-mm resolution.

#neuroskyence @precisionneuro.bsky.social

Earlier this year, @parallelsq.bsky.social hosted a research fest.

We began with a broad perspective:
◾️ A century of remarkable progress! Proteomics drove conceptual discoveries and medical treatments.

Listen to what's next!

Proteomics: The arc of progress
youtu.be/Sc2QLXb84XI?...

Intercellular communication in the brain through a dendritic nanotubular network Intercellular nanotubular networks mediate material exchange, but their existence in neurons remains to be explored in detail. We identified long, thin dendritic filopodia forming direct dendrite–dend...

🤯

www.science.org/doi/10.1126/...

Food trade disruption after global catastrophes Jehn et. al (2024) highlight the vulnerability of the global food trade system to major disruptions caused by global catastrophic risks (GCR), such as an Abrupt Sunlight Reduction Scenario (ASRS) resu...

Announcing ALLFED's new study in Earth System Dynamics: Even modest crop declines from nuclear war or infrastructure collapse could trigger cascading food trade disruptions. Global food systems are more fragile than we think. allfed.info/research/pub...

Wonderful to collaborate with, and to support as an advisor, E11 Bio - and to announce PRISM, a technology for mapping brains in a self-correcting way, by barcoding neurons followed by expansion microscopy! Thread below by E11 Bio CEO Andrew Payne, with preprint at, www.biorxiv.org/content/10.1...

Long story short: PRISM has the potential to solve the connectomics reconstruction bottleneck for good. Fantastic collaboration with E11, MIT, and the Crick!

hello, we are working on brain mapping and now you can read about it! it has beautiful neurons (shout out to cell 1492), cool multiplexing tricks, and cell barcodes. there are live data links, my first addgene collection and much much more

The Molecular Brain Mapping group at the MRC-LMB is hiring! 🌈🧠

I'm looking for people who are excited about developing multimodal analysis and visualization tools to capture the "hidden connectome," in a highly intersectional environment exploring ideas in meta-science.

mrc.tal.net/vx/mobile-0/...

E11's self-correcting neuron barcoding technology PRISM is getting us closer to scalable connectomics — this will enable connectomics research we've been dreaming of for decades 🌈🧠🔬

Our sister FRO E11 Bio is well on their way to mapping every neuron in the brain. Check out their work on PRISM out today!

A 3D rendering of a network of neurons from a rectangular volume. Each neuron is filled with a slightly different color, making each cell body and its projections distinct from its neighbors.

New AAV tools from @e11bio.bsky.social! PRISM uses protein-tag barcodes for high-throughput reconstruction of neurons and other cell-labeling applications. https://twp.ai/4iruEB

Such a cool achievement!

Combinatorial protein barcodes enable self-correcting neuron tracing with nanoscale molecular context Mapping nanoscale neuronal morphology with molecular annotations is critical for understanding healthy and dysfunctional brain circuits. Current methods are constrained by image segmentation errors an...

Preprint: www.biorxiv.org/content/10.1...

Portal and gallery: www.e11.bio/tech

Addgene constructs: www.addgene.org/depositor-co...

Volara: github.com/e11bio/volara

Open data: github.com/e11bio/e11-o...

E11 Bio is excited to unveil PRISM technology for mapping brain wiring with simple light microscopes. Today, brain mapping in humans and other mammals is bottlenecked by accurate neuron tracing. PRISM uses molecular ID codes and AI to help neurons trace themselves.

Read more: e11.bio/blog/prism

Proud of @e11bio.bsky.social's early progress here, and excited for so much more to come (that I've seen previews of as a FRO board member 😍).

Optics + expansion + barcoding + AI + molecules = beginning of infinity for scalable brain circuit mapping, with wide implications across science.

Sobering physics-of-democracy finding: attractors in social-media dynamics seem to be "networks of outrage."

Certainly rooting for this particular cosmological anomaly to hold up...

Combinatorial protein barcodes enable self-correcting neuron tracing with nanoscale molecular context https://www.biorxiv.org/content/10.1101/2025.09.26.678648v1

PTI is growing and we are looking for more scientists to join our team!

Neurodegenerative Disease Senior Scientist: jobs.lever.co/convergentre...

Computational Biologist: jobs.lever.co/convergentre...

Research Chemist: jobs.lever.co/convergentre...

Inside the UK FRO Founder Residency with ARIA a big step forward in how we source and incubate new FRO projects

This June, we kicked off our first-ever UK FRO Founder Residency as an Activation Partner for the United Kingdom’s Advanced Research + Invention Agency (ARIA), @aria-research.bsky.social.

Read more: www.essentialtechnology.blog/p/inside-the...

Stoked to see this paper finally out!

It answers two big questions: where visual objects are encoded in the brain, and how head-direction cells get oriented using visual landmarks.

Super fun collaboration with @mace-lab.bsky.social and Stuart Trenholm.

www.science.org/doi/10.1126/...

Optical rectennas are not a promising clean energy technology — LessWrong “Optical rectennas” (or sometimes “nantennas”) are a technology that is sometimes advertised as a path towards converting solar energy to electricity with higher efficiency than normal solar cells...

Blog post: Optical rectennas are not a promising clean energy technology www.lesswrong.com/posts/gKCavz...

Cancer-induced nerve injury promotes resistance to anti-PD-1 therapy - Nature Perineural invasion and cancer-induced nerve injury of tumour-associated nerves are associated with poor response to anti-PD-1 therapy, which can be reversed by combining anti-PD-1 therapy with a...

'Electron microscopy and electrical conduction analyses reveal that cancer cells degrade the nerve fibre myelin sheets. The injured neurons respond by autonomously initiating IL-6- and type I interferon-mediated inflammation to promote nerve healing and regeneration'
www.nature.com/articles/s41...