PAIN Reports

New review from Meyers et al. critically discusses the experimental evidence that psychological manipulations can affect the development of secondary hyperalgesia. Learn more in #PainReports bit.ly/4lJQttV

Liu et al. explore the role of lysosomal ion channels in pain. Evidence so far indicates an important role and multiple mechanisms involved. Learn more in #PainReports bit.ly/3HLn6t4

#PainReports and guest editor Anne-Priscille Trouvin are proud to present a new special issue discussing the pathophysiology of fibromyalgia and approaches to treating it. Read the entire issue for free: bit.ly/4jz1MVP

Goebel asserts that most if not all patients with severe fibromyalgia syndrome harbor proalgetic serum-immunoglobulin G autoantibodies; their possible relevance for patients must now be established through clinical trials. Learn more in #PainReports bit.ly/4oNAFJk

Nizard et al. find that the effectiveness of complementary medicines in fibromyalgia is greater, and its risks lower when symptoms are appropriately targeted and experienced professionals are involved. Learn more in #PainReports bit.ly/3HzVIhM

Malafoglia et al. find that mu-opioid receptors percentage of expression on B-cell surface could represent a time stable chronic pain biomarker in fibromyalgia. Learn more in #PainReports bit.ly/4lzQd0l

Mohiuddin et al.’s systematic review has revealed little evidence for combination pharmacotherapy to treat chronic pelvic pain. Future high-quality trials are needed in this area. Learn more in #PainReports bit.ly/45AI7OY

Conroy et al. find that modeling of baseline factors did not predict successful initiation or maintenance of buprenorphine treatment for chronic pain in enriched enrollment randomized withdrawal studies from the FDA database. Learn more in #PainReports bit.ly/4oGSXvD

Nissen et al. find that the CHIPPS behavioral assessment was more effective than skin conductance algesimetry for pain detection in postsurgical infants and combining both methods may improve pain management. Learn more in #PainReports bit.ly/4oLK8kn

Romero-Serrano et al. find that pain management using a closed-loop spinal cord stimulation in a patient with an implantable cardioverter defibrillator can be safely performed without interference between the devices. Learn more in #PainReports #PainAwarenessMonth bit.ly/45Mbv5d

Do you have any thoughts on medical jurisprudence in the context of chronic musculoskeletal nociplastic pain? Check out Editor Allan Basbaum’s comments on the article published by Assis et al. in @painreports.bsky.social bit.ly/4mJKF52 #PRF #EditorsPick #PainAwarenessMonth

Nickerson et al. find that novel adaptive recall-by-genotype study demonstrated no effect of TRPA1 putative gain-of-function polymorphism on sensory function in naïve or cinnamaldehyde-sensitized skin. Learn more in #PainReports #PainAwarenessMonth bit.ly/4oKlikM

The August 2025 issue of #PainReports is now available! Read the entire issue for free at bit.ly/4m469ca #PainAwarenessMonth

Navarro et al.’s exploratory clinical trial analyses suggest that fibromyalgia pain is more intense in the evening. This pattern should be studied further, particularly when investigating fibromyalgia interventions. Learn more in #PainReports #PainAwarenessMonth bit.ly/4p4carB

PAIN Reports

A nationwide cross-sectional study 2025 by Hellmann et al. found more than one-fourth affected by chronic noncancer pain related mainly to high-impact chronic noncancer pain in 8,643 adult Danes. Learn more in #PainReports bit.ly/45LIC9i

PR 27 August

Gonzales et al. find that natural speech characteristics can be used as biomarkers of pain and are linked to baseline pain sensitivity, and speech production reliably reduces pain intensity. Learn more in #PainReports bit.ly/4oNrOat

The August 2025 issue of #PainReports is now available! Read the entire issue for free at bit.ly/4m469ca

PAIN Reports

Goncalves et al. compared a cohort of de novo post-COVID-19 pain to a chronic pain cohort with knee osteoarthritis and investigated opioid receptor Mu 1 polymorphisms. Learn more in #PainReports bit.ly/3Ve2xIQ

PAIN Reports

Tseng et al. used mouse models to determine that the conditional overexpression of contactin-associated protein-like 2 in DRG neurons does not affect neuropathic pain behaviors but reduces sensitivity to capsaicin. Learn more in #PainReports bit.ly/419BqSJ

Tseng et al. used mouse models to determine that the conditional overexpression of contactin-associated protein-like 2 in DRG neurons does not affect neuropathic pain behaviors but reduces sensitivity to capsaicin. Learn more in #PainReports bit.ly/45qn5Tp

Motohashi et al. demonstrate that inflammation-related, pain-related, and emotion-related signaling remain elevated in both the peripheral and central nervous systems, accompanied by ongoing stress responsiveness. Learn more in #PainReports bit.ly/3JhZRYg

The August 2025 issue of #PainReports is now available! Read the entire issue for free at bit.ly/4m469ca

Adeno-associated virus-mediated expression of multiple pronociceptive Nav peptide inhibitory peptide aptamer NaViPA1 in peripheral sensory neurons attenuates stimulated and spontaneous pain in osteoarthritis. Learn more in Shin et al. #PainReports bit.ly/4oQM6Qy

Kang et al. find that brief pain inventory numerical rating score greater than 1.5 (worst pain), 0.5 (average pain), and 0.8 (pain interference) defines unacceptable persistent pain after breast cancer surgery. Learn more in #PainReports bit.ly/40SOqfA

The August 2025 issue of #PainReports is now available! Read the entire issue for free at bit.ly/4m469ca

Dutkiewicz et al. identified 81 quality indicators for opioid stewardship, which can be applied to develop future standards. Learn more in #PainReports bit.ly/4ovezeA

For people with an acute episode of low back pain, Chang et al. find that processing of non-noxious sensory inputs changed over time differentiated 6-month pain, but not disability outcome. Learn more in #PainReports bit.ly/3FoaRld

What can speech tell us about pain? - Redenlab A new study published in the European Journal of Human Genetics provides the first systematic analysis of speech and language difficulties in individuals with KIF1A-associated neurological disorder (K...

Can your voice reveal how much pain you’re in?

Our new study with #UniMelb published in @painreports.bsky.social shows speech can serve as marker of acute pain and speaking might help reduce it. 🤕

🔗 Read more: redenlab.com/what-can-spe...

Validity and contributions to pain from the central aspects ... : PAIN Reports is. Objectives: Given the different pathophysiology of rheumatoid arthritis (RA), an inflammatory polyarthritis, this cross-sectional study assessed CAP's psychometric properties and its associatio...

Great to have this published in @painreports.bsky.social
doi.org/10.1097/PR9....
Congratulation Stephanie Smith and team. I was happy to provide further CAP-RA data for analyses as part of the SOCRATES data collection funded by
@researchwales.bsky.social
@ctrcardiffuni.bsky.social

Kumar et al. find that patients with migraine without aura exhibit heightened cortisol responses and gene expression changes after a neuroendocrine challenge, suggesting an altered stress response linked to migraine pathophysiology. #PainReports bit.ly/4kLyJyd