PAIN Reports

Yamanaka et al. find that 3-Nitrotyrosine modulates excitatory and inhibitory synaptic transmission in the spinal dorsal horn by inhibiting GABA receptor activity, implicating its role in pain modulation. Learn more in #PainReports bit.ly/4auqeno

Zhao et al. find that boldine inhibits glia activation and reduces neuropathic pain after peripheral nerve injury. Learn more in #PainReports bit.ly/4azLgkV

McPherson et al. find that low-frequency, submotor threshold intraspinal microstimulation leads to a lasting increase in the spatial spread of nociceptive sensory-evoked activity, including after spinal cord injury. Learn more in #PainReports bit.ly/4cpSnyz

Haid et al. find that autistic adults assigned female at birth reported high rates of pain-related anxiety that were associated with generalized anxiety and pain interference in their lives. Learn more in #PainReports bit.ly/3NMgGN9

Teichmüller et al. find that spousal empathy and validation were associated with beneficial pain-related and relationship outcomes in chronic pain couples across most studies. The opposite was true for invalidation. Learn more in #PainReports bit.ly/4alApfh

Picañol et al. find evidence supporting Ziconotide’s analgesic promise, but adverse effects and study limitations temper confidence, underscoring the need for rigorous trials before broad clinical adoption. Learn more in #PainReports bit.ly/4qXINrh

Morgan et al. explore over 101 mechanisms of opioid tolerance, highlighting the complexity of identifying specific neural pathways involved and offering solutions to improve study designs. Learn more in #PainReports bit.ly/45F750G

Szmerling et al. assert that a multisite, multidisciplinary analgesic stewardship program may lead to better opioid prescribing at discharge and potentially clinically meaningful reductions in readmission. Learn more in #PainReports bit.ly/45FHpRv

Gaydos et al. find that interleukin-1β and Interleukin-6 are linked to the chronic pain experience: IL-6 is associated with physical symptoms, whereas IL-1β is associated with fear-avoidance and depressive symptoms. Learn more in #PainReports bit.ly/4qNQ6Sc

Guo et al. review the specific mechanisms involved in the regulation of neuropathic pain by 3 noncoding RNAs (ncRNAs) and explore the feasibility of using ncRNAs as therapeutic targets for neuropathic pain. Learn more in #PainReports bit.ly/4qXIMDJ

Tantawy et al. find that lacosamide alleviates oxaliplatin-induced peripheral neuropathy by effectively reducing neuroinflammatory biomarkers and improving 12-item neurotoxicity questionnaire scores, similar to duloxetine. Learn more in #PainReports bit.ly/4qXIMnd

Hattori et al. find that pain and disability in patients with subacromial pain syndrome are associated with pain sensitization rather than with rotator cuff-related factors. Learn more in #PainReports bit.ly/4qK653J

Ishikawa et al. find that offset analgesia reflects stochastic integration processes of prediction and observation with noise filtering for robust pain perception, offering a revision of pain perception theories. Learn more in #PainReports bit.ly/4aktJhw

Clarke et al. find that high-frequency stimulation increased neural activity in pain-related brain regions and altered functional connectivity between key areas of pain modulation, as measured using fMRI. Learn more in #PainReports bit.ly/45FHyEx

Winther et al. find that the effects of acute pain and acute itch are similar on the bilateral corticospinal tract excitability, with corticospinal excitability decreasing in the targeted hand muscle. Learn more in #PainReports bit.ly/4qNLA6n

Lu et al. find that trait mindfulness plays a moderating role in the relationship between EEG responses to pain stimulation and pain perception. Learn more in #PainReports bit.ly/49zUb6z

The OptiMeth-CRPS methodological framework presents strategies for optimizing the quality of clinical trials of interventions for complex regional pain syndrome as a rare pain condition. Learn more in Smart et al. #PainReports bit.ly/4sYC02a

Camara et al. find that chronic pain is independently associated with mortality irrespective of other covariates among Japanese rural women aged ≤74 years in the Shika town longitudinal cohort study, Japan. Learn more in #PainReports bit.ly/3NywCT5

Allmendinger et al. find that chronic CRPS exhibits intact conditioned pain modulation, suggesting the importance of impaired pain facilitatory rather than pain inhibitory processes. Learn more in #PainReports bit.ly/4rg93x1

During a 12-month observation, Higgins et al. found that chronic pain was associated with greater unscheduled health care utilization. Risk factors included analgesic tapering and transitioning from opioid to nonopioid analgesics #PainReports bit.ly/4pHVzbU

Hoq et al. examine translational rodent models of repeated neonatal pain and sucrose exposure, highlighting neurodevelopmental effects and their relevance to clinical care in preterm infants. Learn more in #PainReports bit.ly/4qmHcea

Liu et al. find that bone marrow mesenchymal stem cell-derived exosomes alleviate chronic visceral pain and anxiety in rats with irritable bowel syndrome by activating Nrf-2/HO-1 and reducing oxidative stress. Learn more in #PainReports bit.ly/3Lqsh3q

Yamanaka et al. find that chronic intrathecal JNK inhibition alleviated neuropathic pain and reduced pGAP-43 immunoreactivity in axon terminals, also preventing injury-induced hypertrophy of L1-CAM–labeled varicosities in the dorsal horn #PainReports bit.ly/4q6PFlG

Pedersen et al. find that IBA1- and GFAP-positive cells in dogs with syringomyelia and neuropathic pain may show transcriptomic changes reflecting altered reactivity, upregulated inflammatory processes, and downregulated immune functions #PainReports bit.ly/4qPBCkB

Dol et al. identify 15 unique digital health solutions, primarily videos, from 33 publications related to digital health solutions for caregivers of children experiencing acute pain. Learn more in #PainReports bit.ly/4pkwaWy

Hamwi et al. use machine learning to classify EEG responses in preterm infants, distinguishing between pain and non-pain-related stimuli, offering a step toward improving real-time NICU pain monitoring. Learn more in #PainReports bit.ly/4rCoPTw

Menlah et al. identify the unique challenges faced by nurses and describe strategies in managing pediatric pain in a middle-income country. Learn more in #PainReports bit.ly/3Yaroi8

Buchshtav et al. find that children undergoing air enema reduction of ileocolic intussusception without sedation or analgesia experience considerable pain-related distress. Learn more in #PainReports bit.ly/3LT3Wn1

Schlisio et al. find that the relationship between transgender identity and neuroplasticity suggests a potential influence on the occurrence of phantom limb pain after gender-affirming surgery. Learn more in #PainReports bit.ly/4809jt8

Although the subjective nature of chronic pain symptoms challenges the medico-legal community, Assis et al. argue that physicians must provide unbiased reliable information and remain within the bounds of their competence. Learn more in #PainReports bit.ly/4rlopkl