PAIN Reports

Schlisio et al. find that the relationship between transgender identity and neuroplasticity suggests a potential influence on the occurrence of phantom limb pain after gender-affirming surgery. Learn more in #PainReports bit.ly/4809jt8

Although the subjective nature of chronic pain symptoms challenges the medico-legal community, Assis et al. argue that physicians must provide unbiased reliable information and remain within the bounds of their competence. Learn more in #PainReports bit.ly/4rlopkl

Appraising performance characteristics of the pain Numerical Rating Scale using marginal distribution analysis, Hogans et al. identify efficient pain metrics that represent clinical data more precisely than prior methods. Learn more in #PainReports bit.ly/4r98sxx

Mendes Fernandes et al. report a negative gradient in rehabilitation performance with increasing WHO analgesic ladder; odds of achieving clinically important improvements weaker for low-dose chronic opioid users. Learn more in #PainReports bit.ly/4pdRrAw

Janela et al. find that fear-avoidance beliefs and depression consistently predicted pain outcomes in digital rehabilitation for chronic musculoskeletal pain, emphasizing the importance of tailored, multimodal approaches to optimize recovery #PainReports bit.ly/3K4ziq7

O’Brien et al. find that an inflammatory peripheral blood immune environment, including platelet-neutrophil aggregation, matrix metalloproteinase 9 expression, and Th17 activation distinguishes migraine prodrome and attack #PainReports bit.ly/3WDJCbk

Umeda et al. find that the heightened pain sensitivity among Asian-American adults is not explained by their lower physical activity levels, but racial discrimination may contribute to it. Learn more in #PainReports bit.ly/43XS0pZ

Seangrung et al. assert that telemedicine provides comparable outcomes with in-person visits for chronic pain management, with associated with baseline pain severity and patient education level. Randomized trials are needed. Learn more in #PainReports bit.ly/3XfeCyt

Ho et al. find that associations between variability and discrepancy are unique to pain intensity in older adults and do not extend to mood and fatigue. Learn more in #PainReports bit.ly/3X3xC2S

Timm et al. find that dyscognition was prevalent in patients with chronic pain, with impact on disability, suggesting that dyscognition should be taken seriously in patients with chronic pain. Learn more in #PainReports bit.ly/4hzDyKn

Despite the prevalence of chronic pain within women and birthing people of childbearing age, Bosma et al. report that reproductive health is often overlooked when developing a health care management plan. Learn more in #PainReports bit.ly/47pKOp3

Battell et al. find that spinal neuronal network properties at rest, during innocuous and noxious stimulation, and following experimental synaptic plasticity are significantly altered during postnatal development. Learn more in #PainReports bit.ly/4htUkea

Irfan et al. find that the nuclear enzyme mitogen- and stress-activated kinase 1 expressed in a group of nociceptors is critical for behavior responses in the second phase of the formalin test. Learn more in #PainReports bit.ly/3J8bv8h

The October 2025 issue of #PainReports is now available! Catch up on the latest pain research at bit.ly/3WFO3SR

Basu et al. find that CycK(Myr)R4E, a novel methylglyoxal scavenger with superior proteolytic stability and prolonged circulation time, reduced behavioral and molecular signs of painful diabetic neuropathy in mice. Learn more in #PainReports bit.ly/4qmRGe9

Liu et al. find that electroacupuncture and alfaxalone improve the expression of GABA A receptor via downregulating diazepam-binding inhibitor in the spinal cord and potentiates the antineuropathic pain effect. Learn more in #PainReports bit.ly/476MT7K

Papadomanolakis-Pakis et al. developed 2 risk tools to preoperatively predict moderate-to-severe and severe acute postsurgical pain in the postanesthesia care unit. Both demonstrated acceptable predictive performance and clinical utility. #PainReports bit.ly/46VQdnw

The October 2025 issue of #PainReports is now available! Catch up on the latest pain research at bit.ly/3WFO3SR

Abdelgalil et al. find that SIFIB and L-ESPB nerve blocks provide effective pain relief, reduce opioid use, delay rescue analgesia, and improve patient satisfaction compared with the control group in thigh cancer surgery #PainReports bit.ly/4n45xmF

Kang et al. find that brief pain inventory numerical rating score greater than 1.5 (worst pain), 0.5 (average pain), and 0.8 (pain interference) defines unacceptable persistent pain after breast cancer surgery. Learn more in #PainReports bit.ly/40SOqfA

Are you looking for a top-tier journal to submit your #painresearch about non-vertebrate studies or umbrella reviews? Check out @painreports.bsky.social recent call for submissions for their upcoming special issues bit.ly/3KxMAv2 #PRF

A nationwide cross-sectional study 2025 by Hellmann et al. found more than one-fourth affected by chronic noncancer pain related mainly to high-impact chronic noncancer pain in 8,643 adult Danes. Learn more in #PainReports bit.ly/45LIC9i

PR Call for Submissions OCT 2025

Are you looking for a top-tier journal to submit your #painresearch about non-vertebrate studies or umbrella reviews? Check out @painreports.bsky.social recent call for submissions for their upcoming special issues bit.ly/3KxMAv2

Great to see the OPTIMETH framework for optimising clinical trials in CRPS, brilliantly led by Keith Smart from @ucddublin.bsky.social now out in @painreports.bsky.social

journals.lww.com/painrpts/ful...

@britishpainsoc.bsky.social @efic.bsky.social @iasp.bsky.social @iasp-mesisig.bsky.social

#PainReports and guest editor Anne-Priscille Trouvin are proud to present a new special issue discussing the pathophysiology of fibromyalgia and approaches to treating it. Read the entire issue for free: bit.ly/4jz1MVP

New review from Meyers et al. critically discusses the experimental evidence that psychological manipulations can affect the development of secondary hyperalgesia. Learn more in #PainReports bit.ly/4lJQttV

Liu et al. explore the role of lysosomal ion channels in pain. Evidence so far indicates an important role and multiple mechanisms involved. Learn more in #PainReports bit.ly/3HLn6t4

#PainReports and guest editor Anne-Priscille Trouvin are proud to present a new special issue discussing the pathophysiology of fibromyalgia and approaches to treating it. Read the entire issue for free: bit.ly/4jz1MVP

Goebel asserts that most if not all patients with severe fibromyalgia syndrome harbor proalgetic serum-immunoglobulin G autoantibodies; their possible relevance for patients must now be established through clinical trials. Learn more in #PainReports bit.ly/4oNAFJk

Nizard et al. find that the effectiveness of complementary medicines in fibromyalgia is greater, and its risks lower when symptoms are appropriately targeted and experienced professionals are involved. Learn more in #PainReports bit.ly/3HzVIhM