Guillaume Thibault

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Loss of Fsr quorum sensing promotes biofilm formation and worsens outcomes in enterococcal infective endocarditis - Nature Communications Infective endocarditis (IE) is an understudied biofilm-associated infection. Here, analyses of preclinical and clinical data reveal that the Fsr quorum sensing (QS) system of Enterococcus faecalis is ...

What if quorum sensing doesn’t promote biofilms - but restrains it? 🤔

New work from @harisantypas.bsky.social shows that the Fsr QS system in Enterococcus faecalis acts as a brake on biofilm formation and pathogenesis during infective endocarditis (IE).

www.nature.com/articles/s41...

Postdoc job alert in the Crick Institute in London. Are you interested in the actin cytoskeleton? I am looking for a postdoc to examine the cellular, developmental or physiological role of Arp2/3 iso-complex driven actin polymerisation. Multiple aspects available.
crick.ac.uk/WayPostdoc2026

🚨 I am thrilled to share that our lab has been awarded a new grant!

We will soon be recruiting. This project will focus on dissecting host mechanisms as a direct follow-up 👇

If you are interested in cellular stress responses and host-pathogen interactions, stay tuned or reach out for more details!

Cell Bio 2023-An ASCB|EMBO Meeting Network, learn, and collaborate with top cell biologists from around the globe.

Help shape the @ascbiology.bsky.social #CellBio2026 program!

The official call for session proposals is now open! We are looking for innovative ideas for Minisymposia and Special Interest Subgroup meetings for next year’s meeting.

Submit your proposal by February 22

www.ascb.org/cellbio2026-...

So glad to see this paper out! A small but rewarding contribution from our side. It was a fantastic experience collaborating with @kimingeneva.bsky.social, @ronni.bsky.social, and this great global team on such an interesting manuscript.

Enterococcus fans: Check out our latest on E. faecalis EET, advancing our understanding of both the fundamental physiology of this bug and new mechanisms of its virulence. This is the product of a thrilling collaboration with friends in Singapore @gthibault.bsky.social led by @aarontan.bsky.social.

S’pore study finds new way to disarm antibiotic-resistant bacteria, hasten healing of chronic wounds Singapore scientists have found a new way to disarm antibiotic-resistant bacteria and speed up chronic wound healing using catalase. Read more at straitstimes.com. Read more at straitstimes.com.

Excited to see our work covered by The Straits Times ! A great summary by Judith Tan 👇

www.straitstimes.com/singapore/he...

Proud of this international effort led by NTU Singapore, @scelse.bsky.social and the University of Geneva.

Huge props to first author @aarontan.bsky.social and my co-lead @kimingeneva.bsky.social and other authors including @cenkcelik.bsky.social.

#ScienceAdvances #Microbiology #NTUsg

Crucially, we found that we can reverse this paralysis.

By adding antioxidants (like catalase) to the wound, we neutralized the ROS and restarted the healing process. This could be a new blueprint for treating chronic diabetic ulcers when combined with topical antimicrobials.

The evidence is in the movement (or lack thereof). 👇

Left: Uninfected cells closing the wound.
Middle: Infected cells paralyzed by the bacteria.
Right ΔEET): Mutant bacteria that cannot produce the ROS. Note how the wound closes just like the healthy control!

Most bacteria generate ROS inside their cell but E. faecalis generates ROS outside its cell.

Our study shows this process generates hydrogen peroxide at the wound interface. This oxidative stress triggers the unfolded protein response (UPR) in the host skin cells, stopping them from migrating.

Enterococcus faecalis redox metabolism activates the unfolded protein response to impair wound healing E. faecalis EET generates ROS, which induces the UPR in keratinocytes, inhibiting in vitro migration.

We’ve discovered how the superbug E. faecalis prevents chronic wounds from healing.

It’s not a toxin. It’s metabolism.

The bacteria use extracellular electron transport (EET) to electrochemically generate ROS, effectively "freezing" skin cells in place.

doi.org/10.1126/sciadv.aeb5297

We’re hiring!
@jcellsci.bsky.social is looking for a Reviews Editor to join the team. This is a fantastic opportunity for someone who loves #cellbiology and wants to stay connected with the field. A great chance to work for an organisation that believes in helping the community!

Details below👇

JCS cover: Marking the end of The Company of Biologists' 100-year anniversary, the final journal cover of 2025 features members of our community, including our academic and guest Editors, our FocalPlane Advisory Board, some of the ‘First Person’ and ‘Cell Scientists to Watch’ scientists featured this year, and our in-house team of administrators and editors at our editorial office in Cambridge.

Issue 24 is complete

Marking the end of @biologists.bsky.social 100-year anniversary celebrations, our cover features members of the JCS community, including some researchers from our ‘First Person’ & ‘Cell Scientists to Watch’ interviews.

Explore our ToC: journals.biologists.com/jcs/issue/13...

At the helm of JCS – Editors-in-Chief past, present… and future The Editor-in-Chief (EIC) of Journal of Cell Science plays a key role in defining the overall vision of the journal, helping to decide on journal strategy, policy and priorities, and overseeing all co...

What's it like being Editor-in-chief of @jcellsci.bsky.social? doi.org/10.1242/jcs....

JCS logo Cell Bio 2025 logo Our Editors will be attending Cell Bio 2025 Feel free to reach out with any questions you might have about publishing in the journal or other activities from our not-for-profit publisher The Company of Biologists. Picture of Seema Seema Grewal, Executive Editor, seema.grewal@biologists.com Picture of Amelia Amelia Glazier, Reviews Editor, amelia.glazier@biologists.com X: @J_Cell_Sci Bluesky: @jcellsci.bsky.social Instagram: cell_science_stories

Our Editors will be attending #CellBio2025 @ascbiology.bsky.social @embo.org.

Reach out to @seemagrewal.bsky.social and Amelia Glazier to discuss JCS, @focalplane.bsky.social and our other @biologists.bsky.social initiatives.

Graduate

Our application portal is open until 31 January 2026.

Learn more and apply here: www.ntu.edu.sg/science/admi...

#NTU #NTUScience #PhD #GradSchool #Scholarships #STEM #Singapore

YouTube video by College of Science NTU NTU College of Science PhD opportunities

Ready for a transformative research journey? 🚀

Join the vibrant, interdisciplinary PhD programmes at NTU College of Science in Singapore! We offer fully funded scholarships.

Hear from our students and faculty in the video below 👇

youtu.be/JeZHiXu3fgE

Thank you @jcellsci.bsky.social! It was so much fun chatting with Editor @seemagrewal.bsky.social about my journey, research, and advice for junior scientists.

It’s great that it reads just like our conversation flowed. I sincerely hope it resonates with trainees out there!

Read the interview 👇

Internal documents reviewed by the New York Times reveal Amazon's goal to replace 600,000 jobs with robots.⁠

When we support our local businesses, we create a more stable economy—one not at the whim of billionaires. Support your indie bookshop today and every day 💓⁠

YouTube video by The Company of Biologists Publishing with The Company of Biologists: supporting biologists, inspiring biology

As part of our commitment to Open Access, we support libraries, consortia and researchers. For #OAWeek, we share a recent webinar that includes tips and recommendations for navigating the editorial process and publishing #OA
youtu.be/PjD5QQ-p0Xg
#OAWeek25

Super interesting! I’m curious what’s considered a “high-fiber” diet for people. Looks like the mice were tested on either no fiber or all carbs replaced with fiber? 🌾VS🍞 #microbiomesky 🧪🦠

Definitely well deserved. Congrats!

Congrats 😍. Am I going to e you at ASCB in Philly?

Traditional probiotic from South East Asia. Tempeh, tapai, budu

Where are my tempeh and tapai? 😍

Campus housing 🏡 a big bonus! Plus more than 10 canteens 🥡(we haven't cooked a single meal for a year haha)! My American husband also likes it here :)

And salary? Due to low taxes & subsidized housing, our offer provides a quality of life comparable to a US$215k - $300k salary in major US academic hubs like NYC or the Bay Area. A great deal for your science and your life.

What does our start-up package mean in US terms? It's equivalent to $3.8M package at a top US university. Why? We fully cover PI salary costs and 5 PhD scholarships, so your research grant is for research.

🚨 JOB ALERT!

Ready to lead your own lab? NTU Singapore's Nanyang Assistant Professorship offers a 100% paid salary & a S$2.75M start-up. We're visiting the US this Sept to recruit top talent. Meet us in NYC, Boston & more! #FacultyJobs #TenureTrack

Register 👇 www.cognitoforms.com/Ntu18/NTUSin...