Hendrik Schroeder

TSLP promotes GATA3-expressing effector regulatory T cells via DC2 derived from transitional DCs Nature Immunology - Recent work has revealed that dendritic cells (DCs) are more heterogeneous than previously thought, yet the functional roles of these newly described DC subsets remain unclear....

rdcu.be/e5Ddt

Gut microbiota promotes immune tolerance at the maternal-fetal interface Microbiota-dependent tryptophan-derived indole deficiency is linked to mouse fetal resorption and human recurrent miscarriage. Tryptophan-derived indoles prime MDSCs and RORγt+ Tregs to suppress IFN-γ...

Gut microbiota promotes immune tolerance at the maternal-fetal interface: Cell www.cell.com/cell/fulltex...

Reformation of science publishing: the Stockholm Declaration | Royal Society Open Science Science relies on integrity and trustworthiness. But scientists under career pressure are lured to purchase fake publications from ‘paper mills’ that use AI-generated data, text and image fabrication....

royalsocietypublishing.org/doi/10.1098/...

A photo of a Nobel medal

BREAKING: The Nobel Prize in Physiology or Medicine has been awarded jointly to Mary E. Brunkow, Fred Ramsdell, and Shimon Sakaguchi "for their discoveries concerning peripheral immune tolerance"

Stay tuned for more.
#NobelPrize

Macrophages regulate PD-1 and CTLA-4 expression on ILC2s and their responsiveness in the tumor microenvironment Cellular & Molecular Immunology - Macrophages regulate PD-1 and CTLA-4 expression on ILC2s and their responsiveness in the tumor microenvironment

rdcu.be/eH7DX

Rapid group-2 innate lymphoid cell mobilization from the intestine aids in early lung defense and repair Can et al. show that circulating group 2 innate lymphoid cells (ILC2s) rapidly migrate from the intestine to the lung after helminth infection. These early responders bolster type-2 immunity and barri...

Rapid group-2 innate lymphoid cell mobilization from the intestine aids in early lung defense and repair: Cell Reports www.cell.com/cell-reports...

IL-25-induced memory type 2 innate lymphoid cells enforce mucosal immunity IL-25 treatment induces persistent adaptation of the small intestine, which is maintained by ILC2s with functional and epigenetic qualities of immune memory. Effector-memory ILC2s arise in multiple ti...

IL-25-induced memory type 2 innate lymphoid cells enforce mucosal immunity: Cell www.cell.com/cell/fulltex...

Microbiota-driven antitumour immunity mediated by dendritic cell migration Nature - A newly identified bacterial strain (YB328) isolated from the faeces of patients who responded to immune checkpoint blockade therapies can promote antitumour immunity through the...

rdcu.be/eD52R

Rorγt-positive dendritic cells are required for the induction of peripheral regulatory T cells in response to oral antigens Deleting a regulatory element in the Rorc gene depletes RORγt+ dendritic cells from the intestine in mice, leading to a reduction of regulatory T cells and impaired oral tolerance to antigens. This wo...

Rorγt-positive dendritic cells are required for the induction of peripheral regulatory T cells in response to oral antigens: Cell www.cell.com/cell/fulltex...

Frontiers | Mapping of RORγt+ dendritic cells in human tissues establishes their preferential niche in adult lymph nodes BackgroundThe retinoic-acid-receptor-related orphan receptor gamma t (RORγt) isoform is required for the development of lymphoid organs, T-helper 17 cells (T...

www.frontiersin.org/journals/imm...

rupress.org/jem/article/...

A wave of Thetis cells imparts tolerance to food antigens early in life Within the intestine, peripherally-induced regulatory T (pTreg) cells play an essential role in suppressing inflammatory responses to food proteins. However, the identity of antigen-presenting cells (...

Excited to share our study describing a role for a subset of Thetis cells, TC IV, in tolerance to food antigens. A team effort led by Vanja Cabric and Yollanda Parisotto
www.science.org/doi/10.1126/...

Expansion of Interleukin‐22‐Producing Type 3 Innate Lymphoid Cells in the Gut of Tristetraprolin‐Deficient Mice TTP controls the mRNA stability of multiple inflammatory cytokines. Despite a multiorgan inflammatory phenotype, TTP-deficient mice are protected from experimental colitis, in part, through the expan....

Expansion of Interleukin‐22‐Producing Type 3 Innate Lymphoid Cells in the Gut of Tristetraprolin‐Deficient Mice - Toeuf - 2025 - European Journal of Immunology - Wiley Online Library onlinelibrary.wiley.com/doi/10.1002/...

Spatial mapping of innate lymphoid cells in human lymphoid tissues and lymphoma at single-cell resolution - Nature Communications Innate lymphoid cells (ILC) are an important modulator of immunity in many tissues, including lymphoid tissues, but their spatial information is still scarce. Here, the authors use multiplexed and mul...

www.nature.com/articles/s41...

Soluble CTLA-4 regulates immune homeostasis and promotes resolution of inflammation by suppressing type 1 but allowing type 2 immunity CTLA-4 exists as membrane (mCTLA-4) and soluble (sCTLA-4) forms. Immunological roles of sCTLA-4 are scarcely known. With mice deficient in either sCTLA-4 or mCTLA-4, Osaki et al. show that sCTLA-4, wh...

Soluble CTLA-4 regulates immune homeostasis and promotes resolution of inflammation by suppressing type 1 but allowing type 2 immunity: Immunity www.cell.com/immunity/ful...

RORγt-expressing dendritic cells are functionally versatile and evolutionarily conserved antigen-presenting cells | PNAS Conventional dendritic cells (cDCs) are potent antigen-presenting cells (APCs) that integrate signals from their environment allowing them to direc...

RORγt-expressing dendritic cells are functionally versatile and evolutionarily conserved antigen-presenting cells | PNAS www.pnas.org/doi/10.1073/...

Rorγt-positive dendritic cells are required for the induction of peripheral regulatory T cells in response to oral antigens Deleting a regulatory element in the Rorc gene depletes RORγt+ dendritic cells from the intestine in mice, leading to a reduction of regulatory T cells and impaired oral tolerance to antigens. This wo...

Rorγt-positive dendritic cells are required for the induction of peripheral regulatory T cells in response to oral antigens: Cell www.cell.com/cell/fulltex...

Acute exposure to high-fat diet impairs ILC3 functions and gut homeostasis Xiong et al. report that short-term, high-fat diet exposure rapidly alters the gut microbial and immune environment, disrupting tissue homeostasis. IL-22 production by group 3 innate lymphoid cells (I...

Acute exposure to high-fat diet impairs ILC3 functions and gut homeostasis: Immunity www.cell.com/immunity/ful...

Coordinated IFN-γ/TNF Axis Drives Selective Loss of Activated Enteric Glia in Inflammatory Bowel Diseases Background Enteric glial cells (EGC) play a crucial role in maintaining gut homeostasis, but their dysregulation in inflammatory bowel diseases (IBD) remains poorly understood. Emerging preclinical da...

www.biorxiv.org/content/10.1...

The metabolic sensor LKB1 regulates ILC3 homeostasis and mitochondrial function ILC3s are essential for intestinal defense; however, how metabolism affects their function has remained elusive. Fonseca-Pereira et al. show that LKB1 controls ILC3 function in a cell-intrinsic manner...

The metabolic sensor LKB1 regulates ILC3 homeostasis and mitochondrial function: Cell Reports www.cell.com/cell-reports...

IL-33-activated ILC2s induce tertiary lymphoid structures in pancreatic cancer - Nature IL-33 induces tertiary lymphoid structures.

www.nature.com/articles/s41...

Bile acid receptor FXR promotes intestinal epithelial ferroptosis and subsequent ILC3 dysfunction in neonatal necrotizing enterocolitis Necrotizing enterocolitis (NEC) is a common pediatric emergency primarily afflicting preterm infants, yet its mechanisms remain to be fully understood…

www.sciencedirect.com/science/arti...

Glial-immune interactions in barrier organs are reviewed by @franzeprogatzky.bsky.social and colleagues:
www.mucosalimmunology.org/article/S193...

Cell therapy with human IL-10-producing ILC2s limits xenogeneic graft-versus-host disease by inhibiting pathogenic T cell responses Reid et al. report that IL-10⁺ ILC2 cell therapy inhibits graft-versus-host disease (GVHD) in humanized mice, consistent with patient studies where IL-10⁺ ILC2s are associated with protection from GVHD. Human IL-10⁺ ILC2s express CD49d and CD86 and inhibit allogeneic T cell responses via an IL-4- and IL-10-dependent mechanism. These findings support harnessing IL-10⁺ ILC2s therapeutically.

🎉 New Year, New Paper! We're excited to share our latest study led by @kyletreid.bsky.social, demonstrating human IL-10-producing ILC2s can be harnessed in cell therapies. 🧬✨ www.cell.com/cell-reports...
#Immunology #Transplantation #GVHD #RegenerativeMedicine #CellTherapy #ILC2

Autocrine TGF-β1 drives tissue-specific differentiation and function of resident NK cells Sparano et al. show that tissue-resident NK cells produce TGF-β1 themselves to establish and maintain residency in glandular tissues. In these environments

rupress.org/jem/article-...

ILC2 are a non-redundant source of IL-5 required for development and function of murine B1 cells
www.nature.com/articles/s41...

Frontiers | Global deletion of the immune cell transcription factor, T-bet, alters gut microbiota and insulin sensitivity in mice

www.frontiersin.org/journals/gen...

Congratulations!

Single cell profiling of hematopoietic stem cell transplant recipients reveals TGF-β1 and IL-2 confer immunoregulatory functions to NK cells NK cells exhibit diverse functions shaped by cytokines and microenvironments. We identify TGF-β1highCD56bright NK cells linked to protection from GVHT post-HSCT. IL-2 and TGF-β1 drive NK cells to a transient regulatory phenotype with unique transcriptional profiles, highlighting non-canonical regulatory functions can be induced by these cytokines.

Excited to share our new publication identifying unique features of CD56bright NK cells in HSCT recipients. Here we explore unique features of CD56bright NK cells in HSCT recipients protected from GVHD, and identify factors that shape their functions: www.cell.com/iscience/ful...