Karlseder Lab

2026 DNA Damage, Mutation and Cancer (GRS) Seminar GRC The 2026 Gordon Research Seminar on DNA Damage, Mutation and Cancer (GRS) will be held in Ventura, California. Apply today to reserve your spot.

🧬Register for the GRS on DNA Damage, Mutation & Cancer🧬
Feb 28–Mar 1 2026, Ventura CA
Accepting abstracts for oral presentations! 
📍 Apply here 👉 grc.org/dna-damage-mutation-and-cancer-grs-conference/2026 (www.grc.org/dna-damage-m...)
#DNADamage #GRC#GRS #CallForAbstracts

Another great read from the lab (this time with @joenassour.bsky.social) on how telomere crisis stands at the crossroads of cancer suppression and evolution 🧬

Our lab’s latest “hot take” is out in Genes & Development!
We argue for looking beyond senescence to understand how telomeres connect aging, tumor suppression, and inflammation.
Great job @sambloom28.bsky.social!

👉 DOI: 10.1101/gad.353122.125
genesdev.cshlp.org/content/earl...

A CPC-shelterin-BTR axis regulates mitotic telomere deprotection Nature Communications - Here the authors reveal how telomeres signal mitotic stress. A key protein network alters their structure exposing telomere ends to signal mitotic stress, ultimately...

🧵 1/10 Excited to share our latest study in @naturecomms.bsky.social
"A CPC-shelterin-BTR axis regulates mitotic telomere deprotection" t.co/VypPsLBJCR

A CPC-shelterin-BTR axis regulates mitotic telomere deprotection - Nature Communications Here the authors reveal how telomeres signal mitotic stress. A key protein network alters their structure exposing telomere ends to signal mitotic stress, ultimately triggering a controlled DNA damage...

1/Out today in @naturecomms.bsky.social,

“A CPC-shelterin-BTR axis regulates mitotic telomere deprotection”.

Here we identify the mechanism that unwinds telomere-loops (t-loops) during mitotic arrest to activate the DNA damage response and signal mitotic stress.

www.nature.com/articles/s41....

Great opportunity for those looking for a faculty position!

Huge thanks to Hannah Trost, Gabriel Matos Rodriguez, Roger Greenberg, and Hilda Pickett for an amazing Mammalian DNA Repair GRS/GRC in Ventura! Already excited for the next one!

Homologous recombination promotes non-immunogenic mitotic cell death upon DNA damage - Nature Cell Biology Szmyd et al. show that DNA repair pathways impact whether cells with DNA lesions arrest in mitosis. The formation of homologous recombination-driven double Holliday junctions elicits mitotic cell deat...

1/Delighted to announce the newest paper from our lab, “Homologous recombination promotes non-immunogenic mitotic cell death upon DNA damage”, is out today in @naturecellbiology.bsky.social, www.nature.com/articles/s41....

We highlight novel ‘humanized’ mouse models addressing these differences, which allow for a direct comparison with human telomeres in the research context of aging and disease. Congratulations to co-authors Corey and Laura on this excellent work!

Telomere function and regulation from mouse models to human ageing and disease - Nature Reviews Molecular Cell Biology Telomere dysfunction, usually owing to shortening, activates cellular senescence and can contribute to age-associated diseases and cancer. Mouse models are crucial for telomere research, but human and...

With our lab’s inaugural Blue Sky post we celebrate our latest publication, a review in Nature Reviews Molecular Cell Biology (@natrevmcb.bsky.social) 🥳
Here, we review our current understanding of telomere biology, discussing differences between human and mouse.
www.nature.com/articles/s41...