Brain Injury Research Center (BIRC) of Mount Sinai

The New England Journal of Medicine Shines Spotlight on Forensic Pathology

www.mountsinai.org/about/newsro...

The NEJM highlights how forensic pathology advances our understanding of long-term TBI effects.
Our collaboration with the NY Chief Medical Examiner’s Office helps us identify biomarkers from brain tissue to enable testing in living people with TBI to prevent long-term consequences.

Distinct clinical phenotypes and their neuroanatomic correlates in chronic traumatic brain injury Accumulating evidence of heterogeneous long-term outcomes after traumatic brain injury (TBI) has challenged longstanding approaches to TBI outcome classification that are largely based on global funct...

MRI data indicated that cognitive & mood/behavioral phenotypes were associated with reduced cortical volumes in specific brain networks compared to phenotype with few deficits which shows promising imaging biomarkers & intervention targets for chronic TBI
pmc.ncbi.nlm.nih.gov/articles/PMC12198765/

Distinct clinical phenotypes and their neuroanatomic correlates in chronic traumatic brain injury Accumulating evidence of heterogeneous long-term outcomes after traumatic brain injury (TBI) has challenged longstanding approaches to TBI outcome classification that are largely based on global funct...

The 4 phenotypes were: 1) mixed cognitive and mood/behavioral deficits 2) predominant cognitive deficits 3) predominant mood/behavioral deficits 4) few deficits across domains. Phenotypes were based on 41 clinical measures and validated through advanced clustering methods.

In a recent Brain Communications paper, BIRC researchers & collaborators used data from the LETBI Study to identify 4 distinct clinical phenotypes in chronic TBI.
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