Faria Tryps Lab

Human cytomegalovirus long non-coding RNA counteracts nuclear cGAS to facilitate immune evasion - Nature Microbiology The authors identify a human cytomegalovirus long non-coding RNA, RNA4.9, that interacts with cGAS and prevents its activation in the nucleus, thereby suppressing virus-induced IFN expression and anti...

#NewResearch

A human cytomegalovirus long non-coding RNA, RNA4.9, that interacts with cGAS and prevents its activation in the nucleus, thereby suppressing virus-induced IFN expression and antiviral activity

#MicroSky 🦠

www.nature.com/articles/s41...

Streptomyces uses both polar and dispersed cell wall synthesis during exploratory growth - Nature Microbiology Streptomyces venezuelae requires MreB1-dependent dispersed peptidoglycan cell wall synthesis and DivIVA-mediated polar cell wall synthesis during its rapid exploratory growth phase.

#NewResearch

Streptomyces use both polar and dispersed cell wall synthesis during rapid, exploratory growth @mcmasteriidr.bsky.social

#BacteriaCellWall #MicroSky 🦠

www.nature.com/articles/s41...

#NewResearch

Cryo-EM structures of the full-length Junin virus and Machupo virus spike glycoprotein complexes stabilized in the prefusion conformation - analyses reveal features that regulate glycoprotein pH-dependent membrane fusion activity.

#MicroSky 🦠

www.nature.com/articles/s41...

RNA Pol II-based regulations of chromosome folding The spatial organization of eukaryotic genomes and its dynamics are of functional importance for gene expression, DNA replication, and segregation. St…

New work from @beckof.bsky.social and our lab's collaboration, with @alengronne.bsky.social! Multifaceted influence of transcription on yeast chromosome folding... loop extrusion of course but also active promoters making loops, bypassing centromeres boundaries
www.sciencedirect.com/science/arti...

A great team effort with @singh-parul.bsky.social Maureen Cabahug, @trypsleon.bsky.social & and the amazing @jessmbryant.bsky.social !!

Huge thanks to our funders @wellcometrust.bsky.social @yorkshirebiodtp.bsky.social @agencerecherche.bsky.social

How do parasites strategically organise their genomes to influence gene expression? If you’re curious, check our latest review in @cp-trendsparasitol.bsky.social !

@biologyatyork.bsky.social @ybri-uoy.bsky.social @pasteur.fr

www.sciencedirect.com/science/arti...

And what a pleasure it was!!!

Parasite genome organization: come together, right now! Links between genome organization and transcription have been extensively studied in model eukaryotes; however, recent application of state-of-the-art chromosome conformation capture techniques to kin...

We @singh-parul.bsky.social teamed up with the amazing @fariatrypslab.bsky.social @trypsleon.bsky.social to highlight how recent technological advances have revealed exciting new features of parasite genome architecture and its impact on survival and pathogenicity:

www.cell.com/trends/paras...

Beyond polyA: scalable single-cell total RNA-seq unifies coding and non-coding transcriptomics https://www.biorxiv.org/content/10.1101/2025.08.08.669394v1

Predicting the translation efficiency of messenger RNA in mammalian cells - Nature Biotechnology A deep convolutional neural network model predicts the influence of the full-length mRNA sequence on translation efficiency.

Predicting the translation efficiency of messenger RNA in mammalian cells go.nature.com/4mgXR0C

Generalizable direct protein sequencing with InstaNexus https://www.biorxiv.org/content/10.1101/2025.07.25.666861v1

The best things Biochemistry at York has to offer - Student Voices Biochemistry at York: A third-year student reflects on how studying biochemistry shaped her academic journey and career goals.

Over a week since Graduation already!

Débora shares her experience:
"Through all challenges I have had to overcome, very notably moving from the other side of the globe alone, I know I would not be here if it were not for my degree and the Department of Biology..."

Read more here - bit.ly/4fznGXD

Decoding post-transcriptional gene expression controls in trypanosomatids using machine learning pubmed.ncbi.nlm.nih.gov/40735494/

🚨 2-year post-doc position available in my lab. More details below. Please repost!

acrobat.adobe.com/id/urn:aaid:...

The essential host genome for Cryptosporidium survival exposes metabolic dependencies that can be leveraged for treatment An arrayed microscopy-based CRISPR screen revealed host genes affecting multiple infection phenotypes of the intracellular parasite Cryptosporidium. Hits in the host cholesterol biosynthesis pathway a...

Our paper has finally graduated from pre-print to peer-reviewed, pretty much unscathed, and is out now! www.cell.com/cell/fulltex...

Mapping multimodal phenotypes to perturbations in cells and tissue with CRISPRmap - Nature Biotechnology Optical pooled CRISPR screening is improved by combinatorial oligo hybridization for barcode detection.

Optical pooled CRISPR screening is improved by combinatorial oligo hybridization for barcode detection go.nature.com/481iCHt
rdcu.be/exfh8

Genome-wide mapping of DNA G-quadruplexes in Trypanosoma brucei chromatin reveals enrichment in coding regions https://www.biorxiv.org/content/10.1101/2025.07.22.666098v1

A novel, high-density CRISPR activation platform for mapping cancer dependencies and resistance pathways ex vivo and in vivo https://www.biorxiv.org/content/10.1101/2025.07.22.666069v1

Structure of an archaeal ribosome reveals a divergent active site and hibernation factor - Nature Microbiology Sequence and structural analyses reveal a divergent peptidyl transferase centre and a hibernation factor in archaea.

Out now:

Structure of an archaeal ribosome reveals a divergent active site and hibernation factor

@jhdcate.bsky.social @banfieldlab.bsky.social @diptinayak.bsky.social & co

#microsky

www.nature.com/articles/s41...

Delighted to share the final version of Richard Zhou's study on how the CD163 scavenger receptor cleans up after toxic haemoglobin spills out from our blood cells. An amazing grabber mechanism!
rdcu.be/ewPA2

Don’t miss this opportunity!! ⬇️⬇️ excellent lab and very exciting projects!

5' untranslated regions tune Toxoplasma translation https://www.biorxiv.org/content/10.1101/2025.07.14.664749v1

Beyond the transcript: chromatin implications in trans-splicing in Trypanosomatids www.biorxiv.org/content/10.1101/2025.07.08.663533v1

mRNA 3′UTRs chaperone intrinsically disordered regions to control protein activity More than 2,700 human mRNA 3′UTRs have hundreds of highly conserved (HC) nucleotides, but their biological roles are unclear. Here, we show that mRNAs with HC 3′UTRs mostly encode proteins with long i...

www.biorxiv.org/content/10.1...

Check this 💥💥💥

Mass Spectrometry Reveals Novel Features of Tubulin Polyglutamylation in the Flagellum of Trypanosoma brucei Tubulin polyglutamylation is a key feature of eukaryotic cilia and flagella that is essential for their function. The diversity of enzymes catalyzing polyglutamylation with different specificities ins...

Finally out! Mass spec analysis of #trypanosome flagellar tubulins reveals some surprises including a new #glutamylation site on beta-tubulin! Many thanks to the teams of Julia Chamot-Rooke and Mariette Matondo!
pubs.acs.org/doi/10.1021/...

Mass Spectrometry Reveals Novel Features of Tubulin Polyglutamylation in the Flagellum of Trypanosoma brucei pubmed.ncbi.nlm.nih.gov/40634267/

High-precision cytosine base editors by evolving nucleic-acid-recognition hotspots in deaminase - Nature Biotechnology Cytosine base editors are made highly precise through targeted directed evolution.

High-precision cytosine base editors by evolving nucleic-acid-recognition hotspots in deaminase - @uchichemistry.bsky.social bit.ly/46yTSaT

Liquid-like transcription condensates locally constrain chromatin in living human cells https://www.biorxiv.org/content/10.1101/2025.07.05.663270v1

A nucleation distance sets the cell size-dependent P-body assembly https://www.biorxiv.org/content/10.1101/2025.07.08.663506v1

Postdoc position open to investigate chronic Toxoplasma infection!

elxw.fa.em3.oraclecloud.com/hcmUI/Candid...