Cole J. Batty

Enhanced human antigen-specific B cell responses using in vitro 3D tonsil cultures containing stromal cells https://www.biorxiv.org/content/10.1101/2025.09.30.679470v1

In the US it is called “Dawn”. We haven’t tried this, but the U.K. and Belgian brands both work fine. If you try Dawn please let us all know!

Just take a look. The Foxp3 fix/perm kit is good for TFs, but kills endogenous GFP. The eBio preserves GFP, but is incomplete at allowing TF staining. Burton's Best Buffer is as good as the best under all conditions (except phospho-flow), and preserves dye integrity too.

Plus it is dirt cheap. 🎤

PRDM1 shapes germinal center B-cell clonal diversity by gating chromatin accessibility during light-to-dark zone transition https://www.biorxiv.org/content/10.1101/2025.08.27.672737v1

Hard not to get excited about his passion

Modulation of B cell receptor activation by antibody competition @cp-cellreports.bsky.social
www.cell.com/cell-reports...

Isolation of genetically diverse influenza antibodies highlights the role of IG germline gene variation and informs the design of population-comprehensive vaccine strategies https://www.biorxiv.org/content/10.1101/2025.07.04.663145v1

Are you serious?

A systems immunology analysis of Alzheimer’s disease reveals an age- and environmental exposure-independent disturbance in B cell maturation Alzheimer’s disease is a severe neurodegenerative disorder, with multifactorial mechanisms of disease development and progression. Evidence from genetic association studies, animal models, and clinica...

Pre-print time! Our new study on #systemsimmunology analysis of #Alzheimers patients is out now on @medrxivpreprint.bsky.social.

This is the culmination of a long collaboration with Rik Vandenberghe, Stephanie Humblet-Baron and Lidia Yshii's labs at KU Leuven. 🧵1/8

www.medrxiv.org/content/10.1...

Why do you say they knew?

If you are making a detection SSA library, may I humbly request you consider kynurenine & related metabolites

Preprint: In vitro induction of human germinal center B-cells
www.researchsquare.com/article/rs-6...

Be safe

You might flush out all the mental health

Who cares about fringe people amplified by the media/online? Do you have a problem with his platform/ideas?

Can be both

Sycophants are selected to rise to the top

Technology

We are still recruiting a B-cell immunologist to join our team and lead projects funded by the Gates Foundation and NIH. If you are looking for a postdoc or a more senior Staff Scientist position, please apply!

Please repost to help reach out to our colleagues affected by recent RIFs. Thank you!

So embarrassing

Don't sleep on LINE1s!

Michael Cancro (1949–2025) Just a few weeks ago, researchers and educators connected to immunology lost a wonderful friend and colleague: Michael Cancro, professor of pathology and lab medicine at the University of Pennsylvania, passed away suddenly at his home just outside Philadelphia. He will be deeply missed.

Rest in peace to inspiring scientist and mentor Michael Cancro www.cell.com/immunity/ful...

We are Hiring! Join our multi-disciplinary team as a Postdoc or a Bioinformatician in B-cell Immunology to lead exciting projects on human immunology funded by the Gates Foundation and the NIH (Position fully funded and not dependent on future grants).

We are #Hiring! Please share!
#ImmunoSky 🧪
Join our multi-disciplinary B-cell team @Emory/ATL to lead exciting projects on human immunology funded by the Gates Foundation and the NIH (Position fully funded and not dependent on future grants).

ghosnlab.science/join-us
#BYourCell

Two distinct durable human class-switched memory B cell populations are induced by vaccination and infection @cp-cellreports.bsky.social
www.cell.com/cell-reports...

Cool

Ectopic germinal centers in the nasal turbinates contribute to B cell immunity to intranasal viral infection and vaccination | PNAS The nasal mucosa is the first immunologically active site that respiratory viruses encounter and establishing immunity at the initial point of path...

Our latest study by PhD student #RomainGailleton shows that upon #influenza infection, #Bcell can respond rapidly by forming ectopic #GerminalCenter within the nasal tissue.
The work has just been published in @pnas.org (1/N)

www.pnas.org/doi/10.1073/...

They're not really the same thing. Long COVID can occur after a single infection and has distinct symptoms. An analogy would be how ebv acutely causes mono in many but subsequently causes MS in a few.

Trump’s NIH Cuts Send Shockwaves Through the Science World — Odd Lots

@labonnelab.bsky.social

overcast.fm/+AA5AWObyBF8

What an unbelievably great appearance with amazing focus and insight by Professor LaBonne. Thank you so much!

I'm happy to have played a small part in this first paper from an ongoing collaboration between the Marasco, Sage, Haigis, and Hemberg labs to decipher mechanisms of poor influenza vaccine response in older individuals

Early influenza virus exposure shapes the B cell response to influenza vaccination in individuals 50 years later To understand the influence and longevity of early influenza imprinting, Spangler et al. investigate the response to an H2 HA vaccine in individuals with and without exposure to H2N2 virus 50 years ago. They find that those with prior exposure have a…

Online now: Online now: Early influenza virus exposure shapes the B cell response to influenza vaccination in individuals 50 years later