Cole J. Batty

We are hiring a Post Doc in Immunoengineering focused on cell-based therapies for autoimmune disease & Glioblastoma.

Seeking expertise in biomaterials + in vivo disease models (autoimmune/oncology preferred).

Send CV to ainsliek@email.unc.edu

Apply: unc.peopleadmin.com/postings/313...

Strain-specific differences in the response to egg-derived versus recombinant protein influenza vaccines https://www.biorxiv.org/content/10.64898/2026.02.23.707528v1

Thank you for listening to your constituents!

Interesting, I thought there would be a section about building impenetrable berms in the bike lane at every corner to render the cleared lanes useless?

Massive resource!

Followed you for sf stuff and now you're sharing an amazing immunology paper that inspired my current research!

Kynurenine pathway dysregulation plays a key role in so many different conditions (including aging). IDO/TDO inhibition has not worked out well so far, but this paper suggests some other targets.

You should correct your post. it's phone footage and that's an important distinction in this context

Wdym ritualistic? Like in mice?

So cool

I've been successfully using Burton's buffers with dawn and no Triton for staining an endosomally localized membrane protein.

If you really optimized the vax formulation mRNA is not gonna make anything better imo.

Computational Immunologist - Boston, Massachusetts (US) job with Ragon Institute of MGH, MIT, & Harvard | 12849577 The Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology, and Harvard in Cambridge MA, together with the Departmen

The @ragoninstitute.bsky.social is launching a new faculty search for a computational immunologist! Applications are open now and reviewed on a rolling basis. Please share broadly with your networks! #immunosky

www.nature.com/naturecareer...

Plasma-localized IgG glycosylation is dynamically altered by the endothelium
www.pnas.org/doi/10.1073/...

A common progenitor gives rise to fibroblastic reticular cells and vascular smooth muscle cells in murine lymph nodes @jem.org
rupress.org/jem/article/...

B lymphocytes that enter the germinal center late preferentially differentiate into memory cells that recognize subdominant epitopes https://www.biorxiv.org/content/10.1101/2025.10.30.685663v1

Autoantibody origins in lupus and in relapse post CAR-T therapy https://www.biorxiv.org/content/10.1101/2025.10.20.683393v1

Cooler techniques available every day!

Could it be??

Enhanced human antigen-specific B cell responses using in vitro 3D tonsil cultures containing stromal cells https://www.biorxiv.org/content/10.1101/2025.09.30.679470v1

In the US it is called “Dawn”. We haven’t tried this, but the U.K. and Belgian brands both work fine. If you try Dawn please let us all know!

Just take a look. The Foxp3 fix/perm kit is good for TFs, but kills endogenous GFP. The eBio preserves GFP, but is incomplete at allowing TF staining. Burton's Best Buffer is as good as the best under all conditions (except phospho-flow), and preserves dye integrity too.

Plus it is dirt cheap. 🎤

PRDM1 shapes germinal center B-cell clonal diversity by gating chromatin accessibility during light-to-dark zone transition https://www.biorxiv.org/content/10.1101/2025.08.27.672737v1

Hard not to get excited about his passion

Modulation of B cell receptor activation by antibody competition @cp-cellreports.bsky.social
www.cell.com/cell-reports...

Isolation of genetically diverse influenza antibodies highlights the role of IG germline gene variation and informs the design of population-comprehensive vaccine strategies https://www.biorxiv.org/content/10.1101/2025.07.04.663145v1

Are you serious?

A systems immunology analysis of Alzheimer’s disease reveals an age- and environmental exposure-independent disturbance in B cell maturation Alzheimer’s disease is a severe neurodegenerative disorder, with multifactorial mechanisms of disease development and progression. Evidence from genetic association studies, animal models, and clinica...

Pre-print time! Our new study on #systemsimmunology analysis of #Alzheimers patients is out now on @medrxivpreprint.bsky.social.

This is the culmination of a long collaboration with Rik Vandenberghe, Stephanie Humblet-Baron and Lidia Yshii's labs at KU Leuven. 🧵1/8

www.medrxiv.org/content/10.1...

Why do you say they knew?

If you are making a detection SSA library, may I humbly request you consider kynurenine & related metabolites