Tommaso Cavazza

Human eggs must segregate their chromosomes with exquisite precision — yet errors rise with maternal age, causing miscarriage & infertility.
Our new article on @biorxivpreprint.bsky.social shows why chromosome cohesion fails in aging eggs & how to improve it.
www.biorxiv.org/content/10.6... (1/10)

Fluorescence microscopy image of an ovarian follicle (light blue/magenta), with a bright central oocyte.

💥🥚 ANR-funded Assistant Engineer position open in our “Control & Dynamics of the Ovarian Cycle” group at IBDM Marseille 🇫🇷

Work on mouse lines + lab logistics + follicle culture/imaging 🔬

🗓️ Apply by 26 Jan: emploi.cnrs.fr/Offres/CDD/U...

Please share widely — especially with colleagues in France!

Thank you www.humanreproduction.uzh.ch/en.html specially @cavazzalab.bsky.social for two days discussing the science, ethics and history of #HumanReproduction. An impressive and much needed multidisciplinary intiative.

@krauthammerlab.bsky.social @einwuerfe.bsky.social @alicemargaria.bsky.social

Many thanks to you, very exciting visit!

We enjoyed your Annual Lecture in Reproduction and your stimulating inputs to our interdisciplinary project!

Your visit reinforced our vision that such interdisciplinary discourse is essential when approaching reproductive medicine research!

🚨JOB ALERT🚨

FRIENDS PLEASE SPREAD and RT

We are building a small expert team within the @bokelab.bsky.social at @crg.eu @prbb.org to investigate fundamental questions in oocyte cell biology, focusing on how proteostasis regulation influences dormancy and fertility.

See below 2 calls👇

She Worked in a Harvard Lab to Reverse Aging, Until ICE Jailed Her (Gift Article) President Trump’s immigration crackdown ensnared Kseniia Petrova, a scientist who fled Russia after protesting its invasion of Ukraine. She fears arrest if she is deported there.

The Americans are doing to Kseniia what the Russians did to Brittney Griner for having 0.7 grams of cannabis oil. Except no one is coming to negotiate her freedom and Harvard is sitting on their hands. I am so ashamed. Please share this story.
www.nytimes.com/2025/04/11/s...

🚨 PhD Opportunity! 🚨

Passionate about ovarian biology? This cutting-edge PhD project combines live-cell microscopy & biophysical modelling to explore the dynamic ovary! 🧬🔬

I'm happy to chat more—DM or email me to set up a Zoom call 📩 And please share! 🙌🏼

christopher.thomas@univ-amu.fr

🔬🎤 As pre-announced a few days ago... please let us proudly present to you: 𝑴𝒊𝒄𝒓𝒐𝕊𝒑𝒍𝒊𝒕 - your ticket to imaging more, imaging more gentle, and/or imaging more efficient. 🔬

doi.org/10.1101/2025...

Like ❤️, repost 🔂, and most importantly... please send feedback ✉️ our way! 🙏

Reproductive biology is gaining so much from analyzing patient genetic data undergoing reproductive treatments. We look forward to more studies!

Maternal ELL3 loss-of-function leads to oocyte aneuploidy and early miscarriage - Nature Structural & Molecular Biology The authors show that ELL3 maintains chromosomal ploidy by promoting spindle assembly and driving chromosome movement in oocytes. Deficiency of ELL3 results in oocyte aneuploidy and may lead to early ...

@bernhard-m.bsky.social and I wrote a commentary on a cool paper published on NSBM by the Lin lab.

The article is about a new ELL3ment in spindle assembly related to maternally inherited aneuploidy and infertility.

Article👉 nature.com/articles/s41594-024-01471-8

Our commentary👉 rdcu.be/d68El

Join us to a Fondation Singer-Polignac meeting on "Fertility: contribution of the maternal inheritance", 16-17 June 2025 in Paris with a fantastic line-up of speakers! Slots for short-talks. Registration is free but mandatory at: singer-polignac.org/fr/missions/...

Very excited to share our paper on Gene and Transposable Element expression in mammalian preimplantation development, online today! www.cell.com/cell/fulltex...
A short thread to highlight some of our findings 🧵

Happy new year everyone!

We are please to announce the return of MAYosis in 2025!

Every Wednesday in May at 4pm CET, come hear the latest #meiosis4ever stories!

Abstract sub deadline: March 8 (end of day wherever you are)

meiosis.cornell.edu/mayosis2025/

Chromosome mis-segregation triggers cell cycle arrest through a mechanosensitive nuclear envelope checkpoint - Nature Cell Biology Hervé, Scelfo et al. show that chromosome mis-segregation induces mTORC2- and ATR-mediated p53 activation through a mechanosensitive checkpoint at the nuclear envelope triggered by altered heterochrom...

#1 Happy to share our last work published in @NatureCellBio about a new cell cycle checkpoint that senses nuclear shape & mechanics to guarantee genome integrity
www.nature.com/articles/s41.... Great work from @sol-herve.bsky.social & Andrea Scelfo in close collaboration with @katemiro.bsky.social

Interested in starting a PhD to explore ovarian biology through a cross-disciplinary approach combining live-cell microscopy and biophysics?

Get in touch for more details—and please share! 🔬🙌🏼

Postdoctoral Research Associate - Ob/Gyn Position Summary Dr. Amargant-Riera’s research laboratory focuses on understanding the mechanisms that define oocyte quality. The lab uses mouse models and human samples to investigate the mechanical ...

📢 Our lab has just opened a new postdoctoral position!

Are you passionate about the mechanical and molecular control of folliculogenesis? If so, we'd love to hear from you! Contact me at farners@wustl.edu or apply directly here: wustl.wd1.myworkdayjobs.com/en-US/Extern... 1/3

Hi Daniel,
could you please add me to the starter pack?
thanks a lot!
Tommaso

Hi!
Could you please add me to the starter pack?
thanks
best wishes,
Tommaso

Hallo Ursula,
Could you please add me?

Embryonic Signatures of Intergenerational Inheritance across Paternal Environments and Genetic Backgrounds The paternal preconception environment has been implicated as a modulator of phenotypic traits and disease risk in F1 offspring. However, the prevalence and mechanisms of such intergenerational epigen...

📢 Preprint! How does the environment of a father before conception influence offspring?

Even more, how do paternal genetics & ages interact with exposures to affect F1 outcome?

We tested this systematically, with intriguing findings & some cautionary tales🧵...

www.biorxiv.org/content/10.1...

✨ First post on Bluesky ✨

Totally worth studying the #cytoskeleton of #parasites & how they solved problems of survival & reproduction over evolutionary time.

50 days' free access to "Cytoskeletal dynamics in parasites": doi.org/10.1016/j.ceb.2023.102277

Check out our new paper in @currentbiology.bsky.social by amazing grad students @ezlevy.bsky.social and @isabellaleite.bsky.social “A tug-of-war between germ cell motility and intercellular bridges controls germline cyst formation in mice”
authors.elsevier.com/a/1k7fg3QW8S...

Indeed a fun and interesting meeting, met old and new friends.

Thanks David and Andrej for putting it together so nicely.

I came home with the impression that Czech Republic is the country with the highest concentration of embryologist per inhabitant!

Soluble αβ-tubulins reversibly sequester TTC5 to regulate tubulin mRNA decay - Nature Communications When tubulin proteins are present in excess, their encoding mRNAs are selectively degraded in a process initiated by the protein TTC5. Here, the authors show that tubulins themselves reversibly seques...

Hello Bluesky community! What a better way to introduce myself and my research team than post our lab’s first paper freshly off press 🥳🍾

We reveal how tubulins regulate the stability of their mRNA via reversible sequestration of TTC5. Bravo A. Batiuk and all coauthors 👏🏻🥂

doi.org/10.1038/s414...

Hallo BS World!

I look forward sharing and discussing with you my science, interests, and curiosity.

In my lab, we study how cellular processes impact early embryogenesis, especially from right after fertilization until blastocyst formation.

We love live 🔬 to study 🐄 embryos.

Thanks for organising it, could you please add me?