Shailaja Seetharaman

Almost 40 years later, has anyone identified what "buttonin", the 75-kD protein that decorates microtubule like buttons, is? dx.doi.org/10.1083/jcb.104.6.1553

Congrats @cperez-gonzalez.bsky.social!!!

1/ 🎉Excited to share our new preprint @vignjeviclab.bsky.social @davidbrueckner.bsky.social :

"Self-organization of tumor heterogeneity and plasticity"
biorxiv.org/content/10.1...

Tumor heterogeneity and plasticity drive metastasis and relapse. How is tumor patterning coordinated?

A thread👇

We hire!
The CytoMorpho Lab is looking for an engineer with a background in cell and molecular biology to join our team in Paris. This is a 18-month contract position, but we're open to exploring long-term opportunities.
More details here:
cytomorpholab.com/index.php/jo...

Thanks, Nitin! Hope you're doing well!

Pathologists have used nuclear & tissue shapes to diagnose #cancer for decades, but what is the molecular basis for this? In our latest work, we develop a computational pipeline to figure this out in #colorectalcancer! Check out 🧵& preprint #mechanobiology #stemcells www.biorxiv.org/content/10.1...

Emerging mechanomedicines informed by mechanotransduction along the integrin–cytoskeleton–nucleus axis Mechanical forces are fundamental to the formation of normal biological tissues and the maintenance of physiological health. These forces are transmitted from t

Emerging mechanomedicines informed by mechanotransduction along the integrin–cytoskeleton–nucleus axis
pubs.aip.org/aip/apb/arti...

Plasmodium falciparum egress disrupts endothelial junctions and activates JAK-STAT signaling in a microvascular 3D blood-brain barrier model Nature Communications - Here the authors show that Plasmodium falciparum egress products disrupt endothelial barrier and activate JAK-STAT and interferon type response in a 3D blood-brain barrier...

We are happy to show one ourt first exciting papers. We have developed a blood-brain barrier model to study the disruptive effects caused by the malaria parasite, Plasmodium falciparum.

First, congratulations to the fearless @liviapiatti.bsky.social and @alinabatzi.bsky.social

rdcu.be/ezBl7

Congratulations to Thomas Callister, Peter Lu (@petery.lu), Aditya Nandy, Ludwig Schneider, Shailaja Seetharaman (@sseethar.bsky.social), Colm Talbot, Madeleine Torcasso, and Yihang Wang!

Final presentations for Physiology 2025 were last weekend; the students did an awesome job. @sseethar.bsky.social, @andyletzhang.bsky.social, @squishycell.bsky.social, and I were all very proud 🤩.

Thanks, Elias! Hope to see you around sometime soon!

Thanks!

Thanks, Pablo! :)

Thanks!

Thanks! :)

Thanks!!!

Thanks so much, @dianapinheiro.bsky.social. I hope to interact with you more in the future! 🤩

Thanks so much, Manuel! Yesss, and of course actin too. You'll be the first to know (only if you promise to keep watching such movies, haha).

Ha, just remember - never start a western blot on a Thursday because it's bound to fail. And come help me, I'll tell @squishycell.bsky.social that I need you!

Thanks, looking forward to our future collaboration!

Thanks!!

Thanks to the @schmidtsciences.bsky.social AI in Science Postdoc Program, @ahascience.bsky.social, @dsi-uchicago.bsky.social, and the Yen Fellowship for supporting my postdoctoral research.

In the Vascular Mechano-Medicine Lab, we will unravel the mechanobiology of vascular systems to improve human health, with a focus on decoding and engineering tissue function. Starting this fall, we are hiring at all levels, please contact me if you're interested. More details on: shorturl.at/RXKh6

I'm grateful to my advisors and mentors, @etiennemanneville.bsky.social, @squishycell.bsky.social, @manuelthery.bsky.social, Yun Fang, Anne Ridley, and Sasha Bershadsky, as well as colleagues for their immense support and encouragement throughout this journey.

Excited to be starting my research group as a tenure track Presidential Young Professor at the Mechanobiology Institute @mbisg.bsky.social, and the Dept of Physiology at @nusingapore.bsky.social in the fall! More about our work on vascular mechanobiology in health & disease mechano-medicine-lab.com

The first objective of IMBA is to make its scientists successful. Let us help you turn ideas into discovery! IMBA is hiring a Junior Group Leader in the molecular life sciences. Apply below. #hiring #biology #research #groupleader #europe

🌿✨ Calling all mechanobiologists, bioengineers, and curious minds! ✨🌿
Join us in Vietnam this year for an unforgettable Conference on Mechanobiology, where science meets culture in one of Southeast Asia’s most vibrant destinations.
📅 06-12 July
📍 Quy Nhon, Vietnam
🔗 icisequynhon.com/conferences/...

Excited to share our preprint on the molecular architecture of heterochromatin in human cells 🧬🔬w/ @jpkreysing.bsky.social, @johannesbetz.bsky.social,
@marinalusic.bsky.social, Turoňová lab, @hummerlab.bsky.social @becklab.bsky.social @mpibp.bsky.social

🔗 Preprint here tinyurl.com/3a74uanv

Join us Friday April 11 for talks by David Hathcock @davidhathcock.bsky.social (Mechanisms for dissipation-enhanced adaptation & cooperative sensing in bacterial chemotaxis) & Shailaja Seetharaman @sseethar.bsky.social (Mechanosensitive LIM domain protein FHL2 tunes endothelial function) #biophysics

Interpreting regulatory mechanisms of Hippo signaling through a deep learning sequence model Dalal et al. show how AI can be used to systematically uncover the sequence rules that guide how signaling pathways interact with DNA inside cells. This work provides a new lens for discovering the co...

Awesome work showing a super clean + thoughtful application of using genomic deep learning models for discovery.

Interpreting regulatory mechanisms of Hippo signaling through a deep learning sequence model

www.cell.com/cell-genomic...