Jim Woodgett

There should be a Trump version, 50% off!, with empty labs.

She’s not interested in LA 2028. Don’t blame her. 🐿️

Meanwhile, China has massively pivoted to solar and wind, has the highest sales of EVs and has other leverage over oil (export of goods).

The squirrels have been decimating my feeder despite counter measures (elastic bands). Here is Olga Korbnut showing off her dexterity. Hubby is ground feeding her spills.

This is a legitimate use for a pellet gun. Just be careful.

The tardis is bigger on the inside than out. Is this the anti-tardis? If so, best keep it well away from the actual thing.

Hardly pointless if your doctrine sees science as an obstruction at best and a direct refutation of your dogma at worst. Not seeing the 100 years of enormous benefits of science to the US, in particular, is willful, stupefying ignorance. The rest of the world is in disbelief.

Maggie Smith playing the dowager in Downton Abbey, asking what a week-end is - since she has no concept of a work week.

Assuming he’s retired. www.quickmeme.com/img/bc/bc88e...

Cafe de la Monde! A refuge from the insanity.

Way better than most of their menu here.

No sentient being could write that. AI slop is AI slop no matter what shell in comes in.

The tree did drop them from great height presumably to avoid daycare and university fees. She did give them a good jacket.

I mean it’s pretty disturbing, the woodpeckers are carving holes in the tree to store the tree’s babies to eat on another day. WTF did the tree do to the woodpecker?

As in Minnesota, it takes courage to stand up to tyranny and we’ve seen so very little of that by the universities. It’s also obvious that doing nothing simply encourages the destruction of HE. Good for the students.

This particular condition is rare but so are many serious diseases and, collectively, they add up to a large number of patients. Amazing genetic correction that has potential for so many more diseases.

Principal Bermuda Principle awardee! 👏

Inhibitors of Glycogen Synthase Kinase 3 with Exquisite Kinome-Wide Selectivity and Their Functional Effects The mood stabilizer lithium, the first-line treatment for bipolar disorder, is hypothesized to exert its effects through direct inhibition of glycogen synthase kinase 3 (GSK3) and indirectly by increasing GSK3’s inhibitory serine phosphorylation. GSK3 comprises two highly similar paralogs, GSK3α an…

We’ve used BRD0705 for alpha and BRD3731 for beta which gave results in cells and brain slices with genetic KO. From Prof. Florence Wagner:
doi.org/10.1021/acsche…

I’ll look up the ones we’ve used. I don’t recall anyone trying them in flies.

For those who missed it, a reenactment of the State of the Union address.

That’s how you know I didn’t review it 😂 There is a fairly good pair of isoform selective inhibitors from the Broad Institute. By no means perfect, especially at higher doses needed in vivo, but alpha is high in the brain and alpha KOs have several brain phenotypes.

Yup, vacillation over vaccination is vacuous.

And great to see such great work from my alma mater (BSc 78-81)!

Fantastic quote from Kevin Smith on COVID vaccine mandate for healthcare workers: “We were the first hospital in the province that said, if you want to work here, you have to get vaccinated against COVID. A couple hundred people said, “I don’t want to do that.” They didn’t have a good medical reason, and they departed us. And I regret that they departed us. What I don’t regret is...I don’t know why you’d want to work here if you don’t believe in science. That is in our core DNA.”

Kevin Smith (CEO of @UHN) walking the talk. www.theglobeandmail.com/business/rob-m…

Ooooh.. 👏👏 will read this with great interest but methinks the focus on the beta isoform isn’t quite right. Shaggy does look more beta-like than alpha but both are involved in microtubules in mammals. Note lithium and most GSK3 inhibitors are equipotent with both forms (& the DN beta mut has issues)

Wake of the Union.

Canadian physics professor steps back from job over Epstein questions | CBC News A highly regarded theoretical physicist has "agreed to pause his working relationship" with the Perimeter Institute in Waterloo, Ont., where he was one of the founding faculty members, over questions about his presence in the Jeffrey Epstein files released by the U.S. government last month. He's on…

www.cbc.ca/news/investiga…

Indeed, striving to have influence via social media inevitably means being distorted/diluted/polluted by that medium, falling into the trap of being agreeable, popular and sound byte-y, so that you become just another voice. Usually someone elses.

It will be used in Guantanamo Bay and the ICE detention centres.

Kinda think the entire world should have a say.

Yup, been on them for three years (I deferred a year against advice from family Dr) and have had zero side effects and cholesterol/lipid levels dropped exactly as predicted.