hatzakislab

The displacement of the σ70 finger in initial transcription is highly heterogeneous and promoter-dependent Abstract. Most bacterial sigma factors (σ) contain a highly conserved structural module, the ‘σ-finger’, which forms a loop that protrudes towards the RNA

What controls how/when growing RNA unblocks the "door" to exit RNA polymerase? Brilliant duo Anna Wang and Abhishek Majumder led a study in my lab - now out in NAR - on this. *Sequence* matters a lot! Read on... Super smFRET/dynamics work as well. Excited! academic.oup.com/nar/article/...

YouTube video by PyCon AU "Big Brains, Small Targets: Whole-Brain Image Analysis with Python" - Ishrat Zaman (PyCon AU 2025)

Check out the PyCon Au talk from my team member: @ishratz25.bsky.social on the challenges and solutions(?) of cell counting in whole-brain light sheet images! Also give her a follow, she's new here.
www.youtube.com/watch?v=ccLn...

Thank you @krishnanyamuna.bsky.social

Yes indeed. That is exactly the feedback i got. So happy you could join us

Now it’s my turn! Excited to share our latest on GCE & click chemistry for live-cell and super-resolution microscopy 🧬🔬 From precise labeling to functional imaging — come by, join in, and let’s talk science! #CSSB25 #ClickChemistry #Bioimaging

@uniregensburg.bsky.social @uni-wuerzburg.de

What a fantastic (TED ) talk by @krishnanyamuna.bsky.social explain her trifecta of dna nanotech, chemistry and electrophysiology for ion transport in organelles You know a conference discussion is excellent when #keynote speaker actually uses the white board to explain . @isbuc.bsky.social

1st keynote talk of chemical solution to structural biology by #Nobel laureate Brian Kobilka. Fantastic conference organised by @isbuc.bsky.social and department of chemistry UCPH

Chemical solutions to structural biology kick off by #Nobel laureate Morten Meldal . So happy to organise and attend such a event
Check the amazing line up of speakers

isbuc.ku.dk/documents/CS...

Looking forward to have you here Sonja. Thank you for accepting our invitation

Very excited to attend the Mediterranean neuroscience meeting in chania, and present in the special event what we do in my lab in the #COE center of @novo-nordisk.bsky.social and the #nanopans project funded by @lundbeckfonden.bsky.social

#hatzakislab #machinelearning #singlemolecule

Sincere wishes for a swift recovery

Physical Virology: across length scales !! Spam/phishing e-mails have been reported from some FEBS Advanced lecture courses. Please be alert and watch out for fraudulent emails offering to arrange registration, accommodation, or other ser…

Very excited to attend the #embo #febs lecture course and have a plenary on 4D microscopy and machine learning analysis of delivery of biologicals. A central part of the @coecenter.bsky.social funded by @novo-nordisk.bsky.social .

meetings.embo.org/event/25-phy...

Hatzakis, KJJ, Kirchhausen and Carmo-Fonseca lab online on zoom.

KJJ and Hatzakis lab at the University of Copenhagen.

One more monthly COE meeting funded by the NNF Challenge Programme was held.

We discussed how material synthesized by KJJ lab are evaluated by all 3 groups and how #MachineLearning analysis by Hatzakis lab can propel #cardiomyocyte research of Carmos-Fonseca lab.

a fanstistc and long lasting collaboration with @kirchhausenlab.bsky.social spearheaded by @jacobkaestelhansen.bsky.social . the wok is funded by @novo-nordisk.bsky.social as well @villumfonden.bsky.social

See our recent article in @natmethods.nature.com on a machine learning model #DeepSPT to rapidly precisely and automatically analyze anomalous diffusion. The model predicted biological identity from diffusion alone indicating that motion beside structure defines function.

siRNA design

For readers interested in siRNA drugs such as Alnylam's just-approved ATTR therapy vutrisiran, here's a comprehensive review
www.nature.com/articles/s41...
rdcu.be/eewvj

Blood biomarkers are beginning to revolutionize #Alzheimers diagnosis and have potential to offer early detection. Could emerging blood test technologies transform patiet care?

Check out my editorial, out now in @jprecmed.bsky.social
👇👇
tinyurl.com/nwk34t7k

#Biomarkers #Dementia #Diagnostics

Happy to see the great progress you guys are making

What a great few days in #bps2025. New interactions new collaborations and great times with a few of my group members

Excited to attend #bps2025 with multiple of my group members. Interested in #machinelearning single particle tracking ? Quantification of lipid nanoparticles heterogeneity in dimensions and mRNA loading ? Direct observation of #lnp entering cell ? Or single enzyme activity ? Just reach out

The registration Chemical solutions to structural biology symposium . Join us for 2 days and 30 speakers exploring state of the art science at the intersection of chemical and structural biology

Please do

Welcome

Congratulations! So nice to see it out Ruben

Opening for a senior postdoc in our single-molecule DNA replication lab! Deadline January 15, 2025!

So sorry to see this ! My sincere condolences to you and your family

We have 4 fully funded #PhD positions available in York! Interested in single molecule biophysics, structural biology, biochemistry and/or physical chemistry? Get in touch! We have state-of-the-art labs in a fun-filled city! Come join us! DM for more or check out:
sites.google.com/york.ac.uk/q...

Sorry to see this Rita ! Hope everything turns out well

can you please include my lab

Great initiative. Could you please add my lab ?