Sebastiano Pasqualato

Please spread the word: the Structural Studies Division @mrclmb.bsky.social is looking for a new tenure-track, independent group leader with an exciting plan in any area of Structural (Molecular & Cell) biology, in discovery biology and/or methods development. 🥳

mrc.tal.net/vx/mobile-0/...

Astounding words and performance. Take 2 mins to listen to it.

How sortilin senses thyroglobulin along its pathway to thyroid hormone release - Human Technopole Human Technopole researchers have identified the molecular mechanisms by which the membrane receptor sortilin binds thyroglobulin along its pathway to the release of thyroid hormones within the thyroi...

🔬 How do proteins know when and how to move? Our @francescryoem.bsky.social Group reveals how sortilin recognises thyroglobulin on its path to #thyroid hormone release via a short, flexible molecular “tag”.

Published in @natcomms.nature.com humantechnopole.it/en/news/how-... @iboniardi.bsky.social

Multiscale structure of chromatin condensates explains phase separation and material properties The structure and interaction networks of molecules within biomolecular condensates are poorly understood. Using cryo–electron tomography and molecular dynamics simulations, we elucidated the structur...

@science.org 🧬🔬 Multiscale structure of #chromatin condensates explains phase separation and material properties | Science www.science.org/doi/10.1126/... @janhuemar.bsky.social et al.

Shapeshifting gates guard the cell nucleus An international study led by the University of Basel has discovered that nuclear pore complexes – tiny gateways in the nuclear membrane – are not rigid or gel-like as once thought. Their interiors ar...

🧪An international study led by Prof. Roderick Lim has discovered that nuclear pore complexes—gateways in the nuclear membrane—are not rigid or gel-like as once thought. Instead, their interiors are constantly moving and rearranging. @unibas.ch @snsf.ch 👉
www.biozentrum.unibas.ch/news/detail/...

I know you've been doing so, with details and clear explanations -to a biochemist- of why the approach is flawed, but maybe something more "down to earth" would also help a computational biologist, an epidemiologist, an MD...

To be completely honest, you run the risk of passing for someone who has a personal issue, rather than a scientific issue driving you. And by knowing you, I know this is not the case.
Suggestion: why not make a "divulgative" post explaining why "condensates" do not need a novel biochemistry?

On the role of phase separation in the biogenesis of membraneless compartments | The EMBO Journal EMBO Press is an editorially independent publishing platform for the development of EMBO scientific publications.

This alternative view of “condensate” biogenesis is compatible with everything that LLPS claims for itself, including the apparent liquid-like behavior that people a bit ignorant of dynamics find so exciting. I explained this here

www.embopress.org/doi/full/10....

Typewritten transcript of letter from Perutz to Watson describing their early friendship in 51-53 and Perutz's recent work on Huntington's disease as well as his imminent demise.

The things you find in your photo roll #2. For some reason, in August 2013 I took a picture of this charming letter from Max Perutz to Jim Watson, written shortly before Max died.

Major modes of behavior within low-pLDDT regions were identified through a survey of human proteome predictions provided by the AlphaFold Protein Structure Database #AlphaFold2 #StructurePrediction #ConditionalFolding doi.org/10.1107/S205...

Very excited that my final postdoctoral work is now online in Cell @cellpress.bsky.social.

www.sciencedirect.com/science/arti...

Using 16 (!) cryo-EM structures, we uncovered how the three proteins coronin, cofilin and AIP1 work together to rapidly disassemble actin filaments.

Medicine Nobel goes to scientists who revealed secrets of immune system ‘regulation’ Mary Brunkow, Fred Ramsdell and Shimon Sakaguchi discovered cells that protect the body from autoimmune diseases.

This year’s Nobel Prize in Physiology or Medicine has been awarded to three scientists for discovering a class of immune cells that help to prevent the body from attacking its own tissues

go.nature.com/3VNrH1s

Congratulations to Dirk Görlich and Steven L. McKnight, 2025 #LaskerAward winners! - “for discoveries that exposed the structures and functions of low-complexity domains within protein sequences” 🧪
@mpi-nat.bsky.social
#Lasker2025 #LaskerLaureate #structuralbiology #phaseseparation

@gabrieleniola.bsky.social @ilpost.it vi segnalo questo errore in un vostro articolo. Nel film di Del Toro Waltz non è Pretorius, né uno scienziato che fa cose dopo la presunta morte del barone. Ciao e keep it up!

Final days to get signed up for the Symposium on Structural Proteomics in Milan, 6-8 October! Registrations and abstract submissions for posters and talks still open until ❗this sunday August 31st!
@humantechnopole.bsky.social
Find out more at ssp2025.squarespace.com

This ‘landmark’ study describes the structural mechanism of strand exchange by the RAD51 filament using cryogenic structural, biochemical, and single-molecule analyses.
buff.ly/Ieh84gj

Excited to share our latest work with @simonbullock11.bsky.social! We looked at how diverse mRNAs get selected for subcellular localization and it turns out that a single protein can recognize different RNA elements using shared features that weren’t apparent before.
www.biorxiv.org/content/10.1...

🧬 We're excited to host the 13th Symposium on Structural #Proteomics at HT in Milan on 6–8 Oct 25! Join this international meeting with talks on protein structure and interactions by crosslinking MS, HDX-MS, native MS, chemoproteomics & more 👉 ssp2025.squarespace.com
▶️ @ssp2025.bsky.social

AlphaFold developer Google DeepMind to fund CASP as NIH funding falls short Protein structure prediction contest CASP gets temporary funding from Google DeepMind as NIH grant runs out.

NEW from me at STAT:

We've learned that DeepMind is going to fund CASP, the protein structure competition that brought Google DeepMind's #AlphaFold to prominence (and a Nobel Prize), as its NIH funding runs out.

More @statnews.com:
www.statnews.com/2025/07/21/c...

🖥️🩺🧪🧬 #bioML

Condensin II activation by M18BP1 Borsellini, Conti, Cutts, Harris, et al. identify an interaction between M18BP1 and condensin II that is essential for condensin II activity and chromatin localization. MCPH1 keeps the interphase genome uncondensed by competing with M18BP1. A phosphorylation-driven switch allows M18BP1 to trigger condensation at mitotic onset.

Online Now: Condensin II activation by M18BP1 Online now:

Excited to share our preprint on the molecular architecture of heterochromatin in human cells 🧬🔬w/ @jpkreysing.bsky.social, @johannesbetz.bsky.social,
@marinalusic.bsky.social, Turoňová lab, @hummerlab.bsky.social @becklab.bsky.social @mpibp.bsky.social

🔗 Preprint here tinyurl.com/3a74uanv

🔴 Registrations are open! Join us at OPEN HT, a day dedicated to #lifesciences research, on the occasion of the 10th anniversary of the MIND district.

Register by 15 April 👉 humantechnopole.it/en/trainings...

The event will be held in Italian.

As always, excellent talk by Alessandro Borsellini from @alessandrovannini.bsky.social Lab, at @humantechnopole.bsky.social, showcasing his work at the 6th AIC-BMM meeting in Firenze! #associazioneitalianacristallografia sezione macromolecole biologiche

Please, reach out if you have complex inquiries or even naïve questions about the application process... or any other matter!

The new Call for Access to services provided by the National Facilities of Human Technopole is online!
Check out our *new services*!
Fully funded access to services, including consumables, as well as complete access to HT and training (for services for which it is applicable)

Great to have @martinpacesa.bsky.social as invited speaker to our weekly Structural Biology Colloquia. Such a solid, functional and impactful workflow 🤩. Thanks a lot for coming!

A real milestone for the local community, today we celebrate the beginning of service provision by @humantechnopole.bsky.social National Facility for Structural Biology. Lucky to have a smiling @luigiscietti.bsky.social (in pic with our Gaetano D'Urso) from IEO as first user to the Cryo-EM Unit.

Excited to see the first batch of biomass safely delivered from our National Facility for Structural Biology @humantechnopole.bsky.social to Filippo Acconcia of Università Roma Tre. A big thank you to our stellar Biomass Unit, onward to more milestones!

Le nuove direzioni del Post - Il Post Innovare nella tradizione!

Abbiamo due notizie: riguardano Luca Sofri e Francesco Costa. Insomma, al Post cambieranno un po' di cose. Le raccontano qui i diretti interessati (anzi, ora possiamo dire: i direttori interessati)

ilpost.link/e1oRRcnU1t