Sebastiano Pasqualato

🧬 We're excited to host the 13th Symposium on Structural #Proteomics at HT in Milan on 6–8 Oct 25! Join this international meeting with talks on protein structure and interactions by crosslinking MS, HDX-MS, native MS, chemoproteomics & more 👉 ssp2025.squarespace.com
▶️ @ssp2025.bsky.social

AlphaFold developer Google DeepMind to fund CASP as NIH funding falls short Protein structure prediction contest CASP gets temporary funding from Google DeepMind as NIH grant runs out.

NEW from me at STAT:

We've learned that DeepMind is going to fund CASP, the protein structure competition that brought Google DeepMind's #AlphaFold to prominence (and a Nobel Prize), as its NIH funding runs out.

More @statnews.com:
www.statnews.com/2025/07/21/c...

🖥️🩺🧪🧬 #bioML

Condensin II activation by M18BP1 Borsellini, Conti, Cutts, Harris, et al. identify an interaction between M18BP1 and condensin II that is essential for condensin II activity and chromatin localization. MCPH1 keeps the interphase genome uncondensed by competing with M18BP1. A phosphorylation-driven switch allows M18BP1 to trigger condensation at mitotic onset.

Online Now: Condensin II activation by M18BP1 Online now:

Excited to share our preprint on the molecular architecture of heterochromatin in human cells 🧬🔬w/ @jpkreysing.bsky.social, @johannesbetz.bsky.social,
@marinalusic.bsky.social, Turoňová lab, @hummerlab.bsky.social @becklab.bsky.social @mpibp.bsky.social

🔗 Preprint here tinyurl.com/3a74uanv

🔴 Registrations are open! Join us at OPEN HT, a day dedicated to #lifesciences research, on the occasion of the 10th anniversary of the MIND district.

Register by 15 April 👉 humantechnopole.it/en/trainings...

The event will be held in Italian.

As always, excellent talk by Alessandro Borsellini from @alessandrovannini.bsky.social Lab, at @humantechnopole.bsky.social, showcasing his work at the 6th AIC-BMM meeting in Firenze! #associazioneitalianacristallografia sezione macromolecole biologiche

Please, reach out if you have complex inquiries or even naïve questions about the application process... or any other matter!

The new Call for Access to services provided by the National Facilities of Human Technopole is online!
Check out our *new services*!
Fully funded access to services, including consumables, as well as complete access to HT and training (for services for which it is applicable)

Great to have @martinpacesa.bsky.social as invited speaker to our weekly Structural Biology Colloquia. Such a solid, functional and impactful workflow 🤩. Thanks a lot for coming!

A real milestone for the local community, today we celebrate the beginning of service provision by @humantechnopole.bsky.social National Facility for Structural Biology. Lucky to have a smiling @luigiscietti.bsky.social (in pic with our Gaetano D'Urso) from IEO as first user to the Cryo-EM Unit.

Excited to see the first batch of biomass safely delivered from our National Facility for Structural Biology @humantechnopole.bsky.social to Filippo Acconcia of Università Roma Tre. A big thank you to our stellar Biomass Unit, onward to more milestones!

Le nuove direzioni del Post - Il Post Innovare nella tradizione!

Abbiamo due notizie: riguardano Luca Sofri e Francesco Costa. Insomma, al Post cambieranno un po' di cose. Le raccontano qui i diretti interessati (anzi, ora possiamo dire: i direttori interessati)

ilpost.link/e1oRRcnU1t

Structural insights into distinct mechanisms of RNA polymerase II and III recruitment to snRNA promoters - Nature Communications The snRNA Activating Protein Complex (SNAPc) mediates snRNA transcription by RNA Pol II and III. Here, the authors have used cryo-EM to resolve the structure of the SNAPc-bound RNA Pol III pre-initiat...

Excited to share the (hard) work of @zawarshah.bsky.social in its final form: www.nature.com/articles/s41...

A lot of insights into RNA Polymerase selectivity at snRNAs promoters !! As these promoters are often used for heterologous expression of RNAs (ie guide RNAs), you better know how they work

Human Technopole - Technician/Senior Technician in Structural Proteomics careers.humantechnop...

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#proteomics #prot-jobs

Wishing everybody a great holiday season form the staff of the National Facility for Structural Biology of @humantechnopole.bsky.social! It’s been a wild year getting things started and opening to the Italian community, but it’s also been wild fun, with these amazing people! Have a great time!

Calling all #SciComm people who specialise in scientific animations. I would like to talk to someone about making some animations to communicate our research in single-molecule biophysics. Please message me if you are interested and share with your networks! 🧪

Human Technopole - Technician/Senior Technician in Structural Proteomics APPLICATION CLOSING DATE: 18 January 2025 About the Institute Human Technopole (HT) is an interdisciplinary life science research institute, created and supported by the Italian government, with the a

All detail about the job position, and how to apply, here: careers.humantechnopole.it/o/technician...

Join an exciting scientific environment, an amazing integrated structural biology research centre, a thriving and booming young life science institute, in a wonderful facility led by @pscryoem.bsky.social 2/3

JOB ALERT!!! The National Facility for Structural Biology at @humantechnopole.bsky.social is HIRING!! BlueSky-less Andrea Graziadei is looking for a technician to join his Unit and push #structuralproteomics to new, uncharted territories!! 1/3

Thanks for the endorsement @pscryoem.bsky.social! Always a great pleasure having the chance to review the activity done so far and putting some of our technologies on the spotlight!
Onto the next one! #biophysics #structuralbiology 🧪

Research integrity on the spotlight today at @humantechnopole.bsky.social with an internal course to bring awareness and share policies on the topic to the whole HT community

Postdocs in Artificial Intelligence Human Technopole (HT) is an interdisciplinary life science research institute, created and supported by the Italian Government, with the aim of developing innovative strategies to improve human health

😱📣 BlueSky-ers: WE NEED YOUR HELP!!! 🙏
All of you who ever liked a lecture of mine...
All of you who liked one of the courses I teach in...
All of you I work(ed) with in one way or another...
All of you who see my desperation! 😜
PLEASE re-post! 🙏 careers.humantechnopole.it/o/postdoc-in...

“Attu bio” is of course “Struct bio” community

. @zawarshah.bsky.social and @nikklena.bsky.social killing it at the Milan Joint Structural Biology Lab Meeting! Great afternoon gathering the Attu bio community in #uniMI
Amazing showcase of @humantechnopole.bsky.social science from @alessandrovannini.bsky.social and @gaiapigino.bsky.social lab

Per chi mette contenuti scientifici, se alla fine del post inserite questa icona 🧪 verrete rilevati dal feed che raggruppa questi contenuti.

The intraflagellar transport cycle - Nature Reviews Molecular Cell Biology Intraflagellar transport (IFT) ensures delivery of selected proteins into cilia. The IFT protein complexes IFT-A and IFT-B polymerize at the base of the cilium to form an anterograde train that facili...

Our review of Intraflagellar transport is out now! We cover lots of the recent advances in our understanding of IFT, and where we think there are still some gaps.
www.nature.com/articles/s41...

Chromosome Segregation and Aneuploidy Aneuploidy is a hallmark of cancer and developmental disorders such as Down syndrome. Understanding how cells accomplish faithful chromosome segregation and how chromosomal instability (CIN) impacts …

Please consider joining us at the next EMBO Chromosome Segregation and Aneuploidy Meeting co-organised by @mcclellandlab.bsky.social @foijer-lab.bsky.social @bendavidlab.bsky.social Elsa Logarinho Dani Fachinetti and myself meetings.embo.org/event/25-ane... 🧬🔬😎

ok to all synchrotron and cryoEM people out there ...a hastily put together starter pack! go.bsky.app/UThze5z

*Chemists