New preprint from the lab is now on Biorxiv and a new structure in pdb!
We show that PML protein has an RNA-binding module, we named PIXEL, which modulates human transcriptome. We determine its structure and sequence-specificity. Such fun project!
www.biorxiv.org/content/10.6...
Check out this exciting new report on NEDDylation of DNA polymerase eta. Happy our lab could contribute to this work led by @nicholaswashton.bsky.social and colleagues.
19.02.2026 00:05 β π 5 π 1 π¬ 0 π 0Staff Research Scientist (CEST MRI, imaging molecular binding and metabolism) F. M. Kirby Research Center, US-MD-Baltimore jobs.kennedykrieger.org/baltimore-md... #NMRjobs #NMRchat π§²
08.12.2025 13:27 β π 0 π 1 π¬ 0 π 0
With the band!
22.11.2025 08:37 β π 2 π 0 π¬ 0 π 0
22.11.2025 07:00 β
π 1
π 0
π¬ 1
π 0
Hi James! Are you going to be at the meeting?
18.11.2025 10:37 β π 0 π 0 π¬ 1 π 0Yay!
17.11.2025 08:50 β π 1 π 0 π¬ 1 π 0Iβm so excited for a chance to visit Australia and looking forward to #AusUb2025
17.11.2025 06:54 β π 6 π 1 π¬ 1 π 1
This October Iβm drawing 1 molecule a day inspired by proteins in pdb @rcsbpdb.bsky.social
Day 23/31
Prompt FIREFLY
Pdb: 2D1R
Luciferase: firefly enzyme catalyzes a light-producing reaction that makes fireflies glow.
Next: ROWDY
Suggestions?
Yay, love it!
05.11.2025 19:24 β π 0 π 0 π¬ 0 π 0Thanks Karolin!
05.11.2025 03:48 β π 0 π 0 π¬ 0 π 0
This October Iβm drawing 1 molecule a day inspired by proteins in pdb @rcsbpdb.bsky.social
Day 22/31
Prompt BUTTON
Pdb: 1ZXK
Like tiny buttons, cell adhesion proteins such as this Cadherin-8 hold cells together to form tissues.
Next: FIREFLY
Suggestions?
As always, interesting suggestion!
03.11.2025 23:55 β π 1 π 0 π¬ 0 π 0
This October Iβm drawing 1 molecule a day inspired by proteins in pdb @rcsbpdb.bsky.social
Day 21/31
Prompt BLAST
Pdb: 1GVR
An oxidoreductase enzyme PETN from bacterium Enterobacter cloacae can bind and degrade high explosives such as TNT π₯
Next: BUTTON
Suggestions?
Thanks!
03.11.2025 03:41 β π 1 π 0 π¬ 0 π 0Intriguing!
02.11.2025 21:20 β π 1 π 0 π¬ 0 π 0Thanks, and congrats on the beautiful paper.
02.11.2025 21:15 β π 1 π 0 π¬ 0 π 0Congratulations!
02.11.2025 15:05 β π 1 π 0 π¬ 0 π 0
This October Iβm drawing 1 molecule a day inspired by proteins in pdb @rcsbpdb.bsky.social
Day 20/31
Prompt RIVALS
Pdb: 8V27 & 8G6S
Two rival histone modifications on a nucleosome. Ubiquitination of H2BK120 activates genes while H2AK119 represses them.
Next: BLAST
Suggestions?
Nope!
31.10.2025 15:51 β π 1 π 0 π¬ 0 π 0
Iβve been traveling to fun places and meeting awesome people at the IPS meeting in Brazil but falling behind on my inktober artwork. Here is the preview for the prompt RIVAL.
Guess what it is!
This October Iβm drawing 1 molecule a day inspired by proteins in pdb @rcsbpdb.bsky.social
Day 19/31
Prompt ARCTIC
Pdb: 3UYU
Meet ice-binding protein (LeIBP) from Arctic yeast that acts like antifreeze!
Next: RIVALS
Suggestions?
Even more so when you look at the pdb in 3D.
21.10.2025 02:40 β π 1 π 0 π¬ 0 π 0
This October Iβm drawing 1 molecule a day inspired by proteins in pdb @rcsbpdb.bsky.social
Day 18/31
Prompt DEAL
Pdb: 9MKL
A handshaking dimer of a tRNA deacylase strikes a deal to keep translation faithful.
Next: ARCTIC
Suggestions?
This October Iβm drawing 1 molecule a day inspired by proteins in pdb @rcsbpdb.bsky.social
Day 17/31
Prompt ORNATE
Pdb: 9MME
For the Escher fans!
An ornate molecular cage made entirely of RNA.
Next: DEAL
Suggestions?
This October Iβm drawing 1 molecule a day inspired by proteins in pdb @rcsbpdb.bsky.social
Day 16/31
Prompt BLUNDER
Pdb: 8G5J
DNA mismatch blunder being fixed by mitochondrial DNA polymerase Ξ³.
Next: ORNATE
Suggestions?
This October Iβm drawing 1 molecule a day inspired by proteins in pdb @rcsbpdb.bsky.social
Day 15/31
Prompt RAGGED
Pdb: 2W8M
A rugged nuclease D212 from a virus that preys on archaea in the scalding waters of hot springs.
Next: BLUNDER
Suggestions?
Week 2 of inktober is over! Here are my first drafts.
16.10.2025 03:33 β π 9 π 1 π¬ 0 π 0
This October Iβm drawing 1 molecule a day inspired by proteins in pdb @rcsbpdb.bsky.social
Day 14/31
Prompt TRUNK
Pdb: 1FNY
Lectin. This old tree house is made of a lectin protein found in the bark of a black locust tree, Robinia pseudoacacia.
Next: RAGGED
Suggestions?
Our new paper is finally out today. An exciting collaboration with the Buhrlage lab. We report an allosteric activator of USP7.
www.pnas.org/doi/10.1073/...
