SFM Microbial Pathogenesis

𝐌𝐨𝐛𝐢𝐥𝐞 𝐠𝐞𝐧𝐞𝐭𝐢𝐜 𝐞𝐥𝐞𝐦𝐞𝐧𝐭𝐬 𝐝𝐨𝐧’𝐭 𝐣𝐮𝐬𝐭 𝐬𝐩𝐫𝐞𝐚𝐝 𝐫𝐞𝐬𝐢𝐬𝐭𝐚𝐧𝐜𝐞: 𝐭𝐡𝐞𝐲 𝐞𝐧𝐜𝐨𝐝𝐞 𝐚𝐧𝐭𝐢𝐛𝐢𝐨𝐭𝐢𝐜 𝐩𝐞𝐫𝐬𝐢𝐬𝐭𝐞𝐧𝐜𝐞, 𝐧𝐞𝐰 𝐬𝐭𝐮𝐝𝐲 𝐫𝐞𝐯𝐞𝐚𝐥𝐬.
In 𝐿. 𝑝𝑛𝑒𝑢𝑚𝑜𝑝ℎ𝑖𝑙𝑎, ICE pP36 generates growth heterogeneity, fuels persister formation, and transfers tolerance to clinical isolates.

✍️ @personniclab.bsky.social & coll.
📖 shorturl.at/jNqHS

🔬 New work from the Mazel Lab engineers programmable conjugative plasmids to selectively target MDR bacteria and the resistance plasmid pOXA-48, blocking its spread in complex communities.

✍️ @amazeld.bsky.social & coll. @pasteur.fr
📖 shorturl.at/GZdJu

#MicroSky #AntibioticResistance #Conjugation

🔬 Calcium triggers natural transformation in 𝐴𝑐𝑖𝑛𝑒𝑡𝑜𝑏𝑎𝑐𝑡𝑒𝑟 𝑏𝑎𝑢𝑚𝑎𝑛𝑛𝑖𝑖, boosting DNA uptake and resistance acquisition, reports the Charpentier Lab. Opens new doors for genetic engineering.

✍️ @labxc.bsky.social & coll.
📖 shorturl.at/F2GGl

#MicroSky #AntibioticResistance #NaturalTransformation

@pasteur.fr

🚨 𝐀𝐈 𝐦𝐞𝐞𝐭𝐬 𝐓𝐁 𝐝𝐫𝐮𝐠 𝐝𝐢𝐬𝐜𝐨𝐯𝐞𝐫𝐲!

Imaging 𝐶. 𝑔𝑙𝑢𝑡𝑎𝑚𝑖𝑐𝑢𝑚 (a model for 𝑀. 𝑡𝑢𝑏𝑒𝑟𝑐𝑢𝑙𝑜𝑠𝑖𝑠) + deep learning reveals known, unseen, and novel antibiotic modes of action from images alone, a leap for TB drug discovery.

✍️ @awehenkel.bsky.social & coll.
📖 shorturl.at/9QPDy

#Tuberculosis #MicroSky

Nouvelle percée en biologie parasitaire ! Une équipe française révèle comment RCC1-2 et APR8 orchestrent la construction de l’apical complex chez 𝘛𝘰𝘹𝘰𝘱𝘭𝘢𝘴𝘮𝘢 𝘨𝘰𝘯𝘥𝘪𝘪.

✍️ @gissotlab.bsky.social @lebrunlab.bsky.social & coll.
📖 shorturl.at/4q68P

New research shows strain-specific epithelial responses to 𝑆. 𝑝𝑛𝑒𝑢𝑚𝑜𝑛𝑖𝑎𝑒, with invasive strains driving distinct STAT3 signaling compared to carriage isolates, offering insight into asymptomatic carriage vs. inflammation.

✍️ @melanie-hamon.bsky.social & coll @pasteur.fr
📖 shorturl.at/a6aAQ
#MicroSky

Tuberculose : comment la bactérie évacue les métaux toxiques pour résister au système immunitaire Le bacille de la tuberculose survit dans les cellules immunitaires en neutralisant des métaux toxiques comme le zinc.

#ResultatScientifique🔎| La bactérie responsable de la tuberculose est capable d'évacuer les métaux toxiques pour résister au système immunitaire

✍️ @oneyrolles.bsky.social
🤝 @ipbstoulouse.bsky.social
📕 buff.ly/4R5iaMB
▶️

Cartoon representing the mycobacterial oxidative phosphorylation system, including cytochromes, NDH-2, and ATP synthase. Taken from Figure 1 of the article.

#Microbiology

The anti-tuberculosis drug bedaquiline targets the mycobacterial ATP synthase, but how that leads to bacterial death is unclear

Here the authors clarify how bedaquiline works

@jnblab.bsky.social @morwan.me
#TBSky #antibiotics #AMR

http://dlvr.it/TQjZ0W

New from @cascaleslab.bsky.social: A new weapon in the T6SS arsenal. Jonas Desjardins et al. uncover a new family of T6SS toxins that target competitors’ metabolic core, defining a novel NAD(P)⁺ glycohydrolase family, Tne5.

📖 shorturl.at/3QhkS

#MicroSky

New research from @pasteur.fr reveals how 𝐿𝑒𝑔𝑖𝑜𝑛𝑒𝑙𝑙𝑎 uses LpDot1 to methylate SFPQ, disrupting paraspeckles & rewiring host splicing, dampening immune genes like NF-κB2 & CD45 for survival.

✍️ @cbuch.bsky.social, @mrolando.bsky.social & coll.
📖 Read the preprint: shorturl.at/kFh8z
#MicroSky

New study uncovers mitochondrial DNA G-quadruplexes as druggable targets in Plasmodium falciparum, with RHPS4 showing strong activity against resistant #malaria parasites.

✍️ Mariam Salim & coll. @ipbstoulouse.bsky.social @lcc-cnrs.bsky.social
📖 shorturl.at/wlVit
#InfectiousDiseases #DrugDiscovery

© NIBSC / SCIENCE PHOTO LIBRARY

New research shows cannabidiol inhibits HIV-1 infection across key mucosal immune cells via TRPV1 activation and CGRP signaling, blocking early transmission events.
A promising avenue for future #HIV prevention.

✍️ CC Barbosa Bomfim & coll. @institutcochin.bsky.social
📖 shorturl.at/Fdz7g
#Microsky

@nathalierolhion.bsky.social @dbikard.bsky.social
@pasteur.fr @crsa-paris.bsky.social @glimmerfhu.bsky.social
@biozentrum.unibas.ch

New study reveals a high-resolution genetic map of how E. coli adapts to the gut, showing diet- and inflammation-dependent metabolism, niche shifts, and unexpected roles for mobile genetic elements.

✍️ @amandinemaire.bsky.social & coll.
📖 shorturl.at/DYSTv

#Microbiome #Pathogenesis #Microsky

Epstein-Barr virus protein EBNA-1 targets the nucleolus in G1/S phase, cuts rRNA synthesis by 50%, and triggers oxidative stress, all via EBP2. A new viral survival strategy?

✍️ M. Chabi, N. Jourdan & coll. @ibps.bsky.social
📖 shorturl.at/uReKo

#Virology #CancerResearch

New study reveals how Pseudomonas aeruginosa delivers the T6SS phospholipase Tle1 and avoids self-intoxication. Structural and experimental data identify Tli1a as the key immunity protein.

✍️ @del-leica99-98.bsky.social & coll.
📖 shorturl.at/hRHg2

#MiscoSky #TypeVISecretion #Pseudomonas

Come and visit me in Paris! #Shigella2026 - travel bursaries deadline tomorrow. Submit your abstracts at www.shigella2026.conferences-pasteur.org/home

Poly-immunity arrays associated with Rhs toxins confer wide protection against competitors Martinkus et al. show that Photorhabdus and Xenorhabdus species encode arrays of immunity genes whose protein products neutralize toxins secreted by competitors. These arrays, often linked to Xer pass...

We propose immuno-centric view of secreted polymorphic toxin diversification and involvement of novel XPC systems in this process! Fantastic work of @jmartinkus.bsky.social with lab of @cascaleslab.bsky.social !
www.cell.com/current-biol...

Creation of new junior research groups at the Institut Pasteur - Call for applications 2026 - Research The Institut Pasteur is launching an international call to recruit new junior research group leaders leveraging cutting-edge transdisciplinary approaches to exploring infectious diseases, host-microbe...

🔬 Call to create junior research groups at the Institut Pasteur

Focus: Infectious diseases, host-microbe interactions, vaccines
Special interest: AI methodologies

📅 Deadline: Feb 9, 2026
👥 2-12 years post-PhD

Apply now 📝 research.pasteur.fr/en/call/crea...

#JobOpportunity #Research

🧬 A new “Life Identification Number (LIN)” system aims to modernize bacterial classification with a clearer, more stable hierarchy. A step forward for genomic taxonomy!
📖 shorturl.at/vkQuS
✍️ @sylvainbrisse.bsky.social & coll.

@pasteur.fr @ox.ac.uk @monashuniversity.bsky.social @lshtm.bsky.social

👏👏👏 Bravo @hakimi.bsky.social on winning the 2025 @inserm.fr Research Prize and the @fondationdefrance.bsky.social Allianz Prize!

Hakimi's team is cracking #Toxoplasma's secrets, and developing innovative therapies to block transmission.

@academiesciences.bsky.social
©Inserm/François Guénet

Scientists can now visually track full-length #HIV genomes hiding inside cells, in real time.
This new imaging technique reveals where silent viral reservoirs form, offering a powerful path toward curative strategies.
#HIVresearch #CureHIV

📖 shorturl.at/ZN6hC
✍️ F. Di Nunzio & coll. @pasteur.fr

Infections don’t enter the body in one big burst, they trickle in over time, new study reveals. This changes how we understand disease and could help us spot early warning signs sooner!

📖 shorturl.at/RxxXo
✍️ @nemopeeters.bsky.social & coll.

@lipme-toulouse.bsky.social
#MicroSky #PlantScience

Viral coinfections aren’t additive, order matters. Flu often blocks COVID via strong IFN responses, RSV can boost later flu, and each pairing triggers unique cell programs. Timing shapes outcomes for care and modeling.
📖 shorturl.at/KH8cf
✍️ @olivierterrier.bsky.social & coll. @ciri-lyon.bsky.social

@cbitoulouse.bsky.social @narjournal.bsky.social

Two M. tuberculosis RelE toxins don’t cut mRNA, they slice 16S rRNA itself, shutting down translation in a totally unexpected way, new study reveals.
A big leap in understanding TB’s survival tricks and new angles for therapies.

📖 shorturl.at/Z8MVX
✍️ @genevauxpierre.bsky.social & coll.
#MicroSky

MONTHLY ANTIBIOTOLERANCE WEBINAR SERIES - Société Française de Microbiologie

🚨 MONTHLY ANTIBIOTOLERANCE WEBINAR SERIES 2025-2026
Friday Nov 14, 3 PM
Invited speakers: Sophie Helaine & Audrey Menegaz Proenca
More info and registration here 👉 www.sfm-microbiologie.org/evenement/mo...
#Microbiology #Microsky

🚨 Save the date!
The Annual Congress of the French Society for Microbiology is heading to Lyon, Oct 7-9, 2026!
An unmissable event for all microbe lovers.

More information coming soon
#SFM2026 #Microbiology #MicroSky
@sfmicrobiologie.bsky.social

In flies and worms, more pathogenic viruses caused greater aging acceleration, and the effect lingered even after clearance, new study reveals.
#Aging #Infection #MicroSky #Virology
📖 shorturl.at/OeYVp
✍️ @rubengonzalez.bsky.social @castellosanjuan.bsky.social
@salehlabparis.bsky.social @pasteur.fr