Ozanne Lab

Life Science Research Professional 1 in School of Medicine, Stanford, California, United States The Brunet lab in the Department of Genetics at Stanford University (https://web.stanford.edu/group/brunet/) is seeking an independent and motivated.....

Interested in the mechanisms of aging and 'rejuvenation'?

Our lab at Stanford has a Research Assistant/Lab manager position open!!

Apply and join our awesome team! 😎 (please share)

careersearch.stanford.edu/jobs/life-sc...

Exploring placental ultrastructure: A review of electron microscopy techniques and emerging methods for resolving 3D organelle architecture - PubMed Trophoblast cells line the surface of placental villi, facilitating the exchange of nutrients, gases, and wastes between the maternal and fetal circulations. The fusion of cytotrophoblast (CTB) cells into the surrounding multinucleated syncytiotrophoblast (STB), is accompanied by a shift in cellular …

New issue of the #PlacentalCellBio reports by
@biomednews.bsky.social

biomed.news/bims-placeb/...

My fav pick is this comprehensive review on the evolution of the study of the ultrastructure of the placenta using EM <3

Former Liberal cabinet minister Kirsty Duncan dies at 59 OTTAWA — Former Liberal cabinet minister Kirsty Duncan has died at the age of 59 following a years-long battle with cancer. Born on Oct.

Gutted to learn of the passing of Dr Kirsty Duncan.

She was a tireless fighter for the people she served, not only her local community in Toronto but others, especially the science & research &
athletics communities too.

She championed equity, diversity, inclusion and made change happen.

🤍🙏🏻

YouTube video by The Physiological Society Exploring the cardiovascular outcome in the offspring of metformin-treated obese mice

Editor's Choice Paper by @jmschoonejans.bsky.social @ozannelab.bsky.social 'Balancing maternal benefits and cardiovascular risks of metformin during pregnancy' now includes a video short by Josca
www.youtube.com/watch?v=H2aB...

Read paper - onlinelibrary.wiley.com/doi/full/10....

Our new review out with @ozannelab.bsky.social exploring the current data from rodent and human studies of GLP1R agonist use in pregnancy and short/ long-term safety for mother and offspring. !https://portlandpress.com/clinsci/article/139/23/1597/236872/Incretin-receptor-agonism-during-pregnancy

Integration of hunger and hormonal state gates infant-directed aggression - Nature Combined behavioural, circuit-level and cellular approaches are used to demonstrate how hypothalamic neurons integrate hunger and oestrous state to drive a switch in how female mice interact with pups...

Out today in Nature: We uncover a neural mechanism for the integration of two internal states - hunger and estrous state - and how this integration shapes pup-directed behaviors in mice.
www.nature.com/articles/s41...

Read our new review that covers the fast moving topic of whether GLP1R agonists such as Semaglutide and Tirzepatide can be used safely in pregnancy.

So many good reports this past week! Take a look at my #PlacentalCellBio selection thanks to @biomednews.bsky.social

biomed.news/bims-placeb/...

I really liked the preprint by Mike Soares' group on PPARG and invasive trophos using a combination of models: pubmed.ncbi.nlm.nih.gov/41278877/

🤩 I’m beyond excited to finally share our paper! 🎉 It’s been a long journey and a true team effort. Congratulations to our outstanding first authors, @lcreimon.bsky.social and Ayden Gouveia, and to all of the co-authors who made this possible 🙌!

www.nature.com/articles/s42...

Maternal obesity during pregnancy disrupts iron homeostasis and promotes fetal hypoxia in the mouse Abstract figure legend Maternal obesity induces systemic inflammation and high insulin and leptin levels, potentially promoting hepcidin release into circulation and thus iron sequestration in specif....

Interesting new paper from the @ozannelab.bsky.social showing maternal iron homeostasis, not placental dysfunction, is associated with fetal hypoxia at e13.5 in obese mouse pregnancy physoc.onlinelibrary.wiley.com/doi/10.1113/...

There are many reasons pregnant women can develop gestational diabetes &
researchers from @ims-mrl.bsky.social are investigating interventions that can be used to mitigate the condition.

Dr @dftwinn.bsky.social
Dr Adriana Paz Cordona Casanova
Dr Lais Vales Mennetti

Listen - buff.ly/7Kymdzy

An excellent podcast from the @ozannelab.bsky.social at @ims-mrl.bsky.social in the lead up to #WorldDiabetesDay 2025

The utility of early gestational OGTT and biomarkers for the development of gestational diabetes mellitus: an international prospective multicentre cohort study - Diabetologia Aims/hypothesis There is no clear consensus regarding accurate risk stratification in early pregnancy for later developing gestational diabetes mellitus (GDM). Therefore, this study aims to evaluate t...

Up front & free to read in our Nov issue #editorspicks: The utility of early gestational OGTT and biomarkers for the development of gestational diabetes mellitus: an international prospective multicentre cohort study link.springer.com/article/10.1...

Challenges with developing nutritional recommendations to improve pregnancy outcomes Susan Ozanne and colleagues argue that strategies are urgently needed to translate knowledge about how maternal nutrition affects children’s long term health into improved population health outcomes ...

www.bmj.com/content/389/...
@ozannelab.bsky.social @ims-mrl.bsky.social

This week @helferlab.bsky.social and I had a great and productive day visiting @mrcharwell.bsky.social to help get set up for my @acmedsci.bsky.social funded animal study. Really excited to be moving forward! 🐭🧠🍔🔬

I’ve been hosting the 7th International Melanocortin Meeting here in Cambridge with my co-organisers Roger Cone, Kate Ellacott @neuroendo.bsky.social and Anne White. Spectacular science! Here we are at the conference dinner! #obesityisnotachoice

Organisers of 7th International Melanocortin Meeting Kate Ellacott, Giles Yeo, Anne White and Roger Cone

The 7th International Melanocortin meeting was full of energy, science & connections old & new. I will miss the excuse to regularly catch up with my fellow organisers Giles @gilesyeo.bsky.social, Anne @annewhite-uom.bsky.social, & Roger Cone. Thanks to Bioscientifica @socendocrinology.bsky.social

Prevention of type 2 diabetes in migrant populations from low- and middle-income countries living in high-income countries - Diabetologia The rising prevalence of type 2 diabetes among migrant populations from low- and middle-income countries (LMICs) living in high-income countries (HICs) presents a significant public health challenge. ...

In our new special issue: Prevention of type 2 diabetes in migrant populations from low- and middle-income countries living in high-income countries link.springer.com/article/10.1.... See the full collection here diabetologia-journal.org/collections/...

Vancouver Coastal Health Research Institute (@vchresearch.bsky.social) Vancouver Coastal Health Research Institute — Leading innovative research with health impact in Canada. vchri.ca

Hey friends and colleagues ! Vancouver Coastal Health Research Institute - VCHRI is now on Bluesky, give them a follow @vchresearch.bsky.social

Efficient stem cell-derived mouse embryo models for environmental studies - PubMed Blastoids are stem cell-derived structures that mimic natural blastocysts by incorporating all three lineages: trophectoderm, epiblast, and primitive endoderm. However, current methods often yield inc...

Here are the curated lists of pubs in the #PlacentalCellBio
@biomednews.bsky.social report from the last two weeks!

biomed.news/bims-placeb/...
biomed.news/bims-placeb/...

My personal choice: this resource from the Zernicka-Goetz's lab! pubmed.ncbi.nlm.nih.gov/40882624/

Enjoy!

Sharing for our colleagues at @edinburgh-uni.bsky.social who are carrying out a survey on weight loss drugs and pregnancy.
Please help us learn more.
Take the survey
👇👇👇👇 app.onlinesurveys.jisc.ac.uk/s/edinburgh/...

Maternal iron deficiency causes male-to-female sex reversal in mouse embryos Nature - Iron-deficient conditions in pregnant mice can cause XY mouse embryos to develop female rather than male genitalia, revealing that iron metabolism has a role in determining male sex in mice.

Very cool paper connecting nutrition, epigenetics and developmental biology. rdcu.be/eptl7

🎉 Thrilled to share my postdoc work, with our preprint out now on BiorXiv here: www.biorxiv.org/content/10.1...

We investigated how the juvenile brain develops the ability to carry out care behaviours towards neonates by an exciting and surprising switch in neural activity and behaviour

🏆 CONGRATULATIONS to Jo Lewis, 2025 winner of the Michael Harbuz Prize!

Jo will speak at #BSNBradford2025 on Glucose-dependent insulinotropic polypeptide regulates food intake and body weight via the area postrema in mice.

Register: bsnbradford2025.oa-e...

“Our children’s lifelong health starts in the first 1,000 days - from conception to age two"

@acmedsci.bsky.social report, co-chaired by our very own co-chair Susan Ozanne @ozannelab.bsky.social underscores that habits and environments established early are hard to change later

Read more 👇

Serge Luquet

Huge congratulations to Serge Luquet on receiving the Silver Medal from @CNRS! So well deserved 👏🏻
www.insb.cnrs.fr/fr/personne/...

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Professor Paolo Vineis next to a quote that reads: "This collaboration between the UK and Italy has revealed that childhood obesity transcends borders – it is a shared challenge requiring coordinated action. The evidence demonstrates that success comes from addressing the systems and environments shaping children’s health, not just individual behaviours."

Co-published with Italy’s Accademia Nazionale dei Lincei, this report shows that success comes from addressing the systems and environments shaping children’s health, not just individual behaviours.

🔗 Read the report: bit.ly/46qy7tN

This analysis comes ahead of the NHS 10-Year Health Plan to address health inequalities and echoes the Council for Science and Technology’s letter - co-chaired by our President Prof Andrew Morris CBE FRSE PMedSci - for bold leadership and cross-govt action to prioritise prevention.

Professor Rosalind Smyth CBE FMedSci next to a quote that reads: "When we address health inequalities in the earliest years, we’re not just improving individual outcomes – we're building the foundations for a healthier, more productive society. The evidence reinforces that prevention, which requires a cross-sectoral approach, must be coordinated across all government departments."

Key evidence includes:

👶 The first 1,000 days of life shape lifelong health
📉 Obesity rates are 2x higher in deprived areas
🏘️ Public health interventions beat individual fixes

Our Vice President (Clinical), Prof @rosalindsmyth.bsky.social CBE FMedSci, shares the importance of early action 👇