Telmo N. Francisco

Our Organic Letters paper on pyridine synthesis and meta-amination is featured as a supplementary cover in Organic Letters! 🎨
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Read it here: pubs.acs.org/doi/10.1021/...

Grateful to Prof. Samuel Guieu, Prof. Nuno R. Candeias, Prof. Rafael F. A. Gomes, and Prof. Carlos A. M. Afonso for their collaboration in this project! Special thanks to Hélio M. T. Albuquerque and Prof. Artur M. S. Silva for their generous support and guidance!

Synthesis and meta-Amination of Pyridines via Multicomponent Cascade Reaction We report a green, multicomponent cascade synthesis of 3-aminopyridines via [1,3′-bipyridin]-1-ium intermediates undergoing Zincke aminolysis with ammonia supported by experimental evidence and DFT calculations. The method offers broad scope (>20 examples), good functional group tolerance, and scalability in batch and flow procedures. Synthetic utility is demonstrated through conversion into 3-halo, 3-hydroxy, and 3-thiopyridines, expanding the access to meta-substituted pyridines through peripheral editing of the unprotected amino group.

Check our new Organic Letters publication! We achieved direct access to free 3-aminopyridines through cyclization and in-situ meta-amination—offering a new solution to a demanding synthetic challenge!

pubs.acs.org/doi/full/10....