Institute of Genetics and Cancer

A photo of Cameron Wyatt through a glass tank containing zebrafish

Cameron Wyatt @modelzebrafish.bsky.social talks about how zebrafish are superior to humans in 'It all went wrong at legs' at @standcomedyclub.bsky.social as part of #TheProvocateurs event.
16 August, 11.25am: edin.ac/3U9R1xU.
19 August, 5.40pm: edin.ac/3HautKr.
@edfringe.bsky.social

An international team of researchers, including #IGC's @cilialab.bsky.social, is investigating one of the body’s most fascinating microscopic structures – motile cilia: t.co/OsZEpVpTfO
@cmvm-edinburghuni.bsky.social

Whole Genome Sequencing of “Mutation‐Negative” Individuals With Cornelia de Lange Syndrome This study was aimed at assessing the diagnostic utility of whole genome sequence analysis in a well-characterised research cohort of individuals referred with a clinical suspicion of Cornelia de Lan....

New Publication:

Whole Genome Sequencing of "Mutation-Negative" Individuals With Cornelia de Lange Syndrome

@uoe-igc.bsky.social

doi.org/10.1155/humu...

GWAS to mechanism: when non-coding is coding. Beautiful insightful science from @gweykopf.bsky.social @simonbiddie.bsky.social Joe Marsh and many colleagues. @uoe-igc.bsky.social @cmvm-edinburghuni.bsky.social www.biorxiv.org/content/10.1...

On #InternationalBlogDay, have a look at our blog page with blogs written by our community about their work, studies and hobbies - highlighting some of the incredible work and people working at #IGC: edin.ac/4m83az2

Around 40 high school students visited #IGC, as part of the work experience programme #ScienceInsightsWeek. They did a tour of the zebrafish facility, attended a talk on Generation Scotland and took part in research taster sessions. Find out more about Science Insights here: edin.ac/3EKJuBd

Registration is open! 🗓️ Join us for a day of engaging discussions, networking and learning as we celebrate the 20th year of Generation Scotland. We are also offering the opportunity to join online
Register today! www.eventbrite.com/e/generation...

"Eczema is an itchy, inflammatory skin condition that can affect every aspect of a person’s life, health and wellbeing." Sara Brown shows how a @scotpen.bsky.social-funded project by ASCUS Art and Science, @edincollegeofart.bsky.social & Eczema Outreach Support aims to change this: edin.ac/3IIXKME

📽️ G&D Tapes 📽️

G&D author Aitana Verdu Schlie tells us about their new work in #GenesDev about CDK4's role during development, with mutations causing microcephaly and growth defects. #OpenAccess @lukastamayo.bsky.social @aitanavs.bsky.social

Read the full story here:
➡️ tinyurl.com/gd352311

Multi-million project to ‘crack the code’ of cilia – tiny structures with big impact on human health An international team of researchers, led by the University of Exeter, have been awarded a Wellcome Discovery Award grant of almost £5 million to investigate one of the body’s most fascinating microsc...

Excited to share that we have received significant funding from the @wellcometrust.bsky.social for a new interdisciplinary consortium project on #cilia coordination and function across scales and organisms! 🎉🥂@lsiexeter.bsky.social

news.exeter.ac.uk/living-syste...

Read this lovely post about @iimcb.bsky.social PhD student Rosa and her experience of doing her research stay at #IGC as part of the #RACEproject 👇

Wishing you all the best with your new lab in Munich!

Institute of Genetics and Cancer Building work has commenced for the new £17.5m building at the Western General Hospital site, which will allow scientists at the University of Edinburgh’s Institute of Genetics and Cancer to…

On #ResearchAppreciationDay we're celebrating all the researchers at #IGC who are working to improve the lives of people living with genetic disease and cancer through research. Read more here:

🚨Fantastic PhD opportunity for Autumn 2025 with our colleague Rebekah Tillotson @uoe-igc.bsky.social, asking whether ATRX syndrome is treatable:
sidb.org.uk/phds/tillots...
Please share 🙏
#epigenetics #raregeneticdisease #chromatinopathies

As a postdoc I found that mimicking #nerve signals could help cell replenishment in #salivarygland. When I joined @edinuni-irr.bsky.social we teamed up with the incredible Unciti-Broceta lab from @uoe-igc.bsky.social to explore a novel #drugdelivery system: 📖 ➡️ www.researchsquare.com/article/rs-6...

New insights into high grade serous ovarian cancer tumour evolution | Institute of Genetics and Cancer | Institute of Genetics and Cancer A study led by researchers at the Institute of Genetics and Cancer has gained new insights into how high grade serous ovarian cancer tumours emerge and grow, opening new avenues to develop better trea...

A study led by @ailithewing.bsky.social has gained new insights into how high grade serous ovarian cancer tumours emerge and grow, opening new avenues to develop better treatments: edin.ac/40vjn9a
@natcomms.nature.com @cmvm-edinburghuni.bsky.social

A specific form of cPRC1 containing CBX4 is co-opted to mediate oncogenic gene repression in diffuse midline glioma Diffuse midline glioma (DMG) is a fatal childhood brain tumor characterized primarily by mutant histone H3 (H3K27M). H3K27M causes a global reduction …

New Publication:

A specific form of cPRC1 containing CBX4 is co-opted to mediate oncogenic gene repression in diffuse midline glioma

@uoe-igc.bsky.social @gerrybrien.bsky.social

www.sciencedirect.com/science/arti...

Scalable inference of transcriptional variability with BASiCS BASiCS (Bayesian Analysis of Single-Cell Sequencing data) is an integrated Bayesian hierarchical model for the analysis of single-cell RNA sequencing …

New Publication:

Scalable inference of transcriptional variability with BASiCS

@uoe-igc.bsky.social @catavallejos.bsky.social

www.sciencedirect.com/science/arti...

Congratulations @scott-wad-dell.bsky.social!

Inherited chromosomally integrated human herpesvirus 6: regional variation in prevalence, association with angina, and identification of ancestral viral lineages in two large UK studies | Journal of V... Human herpesvirus 6 (HHV-6) has the unusual ability to integrate into the host chromosome telomeres. Most of the world’s population is infected by HHV-6 in early childhood, but around 1% inherit the v...

New Publication:

Inherited chromosomally integrated human herpesvirus 6: regional variation in prevalence, association with angina, and identification of ancestral viral lineages in two large UK studies

@uoe-igc.bsky.social @genscot.bsky.social @eduedinburghcrf.bsky.social

doi.org/10.1128/jvi....

Great to see the announcement of this new project led by @cgatist.bsky.social 👇

🚨 New paper out in Development! 🚨

We show that donor embryonic stem cells (ESCs) reshape the developing mouse embryo, not just by what they signal, but where they push.

📄 doi.org/10.1242/dev....

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Ancient genomes: perspectives on human biology and medicine | Genetics Society It is our great pleasure to invite you to participate in the Autumn Meeting of the Genetics Society. This meeting will provide a unique forum to network and socialise with a wide cross-section of the ...

🧬Submit your abstract now – deadline Monday!

This meeting will bring together researchers interested in using ancient genomes to understand the role that migrations, introgression, adaptation & selection, have played in shaping human genetic variation and disease.

genetics.org.uk/events/ancie...

Novel treatment could reduce side effects of anticancer drugs | Institute of Genetics and Cancer | Institute of Genetics and Cancer Researchers have developed a novel type of treatment involving what they call ‘metallic nano-bones’ which offers a way to activate chemotherapy drugs precisely at the tumour site, sparing the rest of ...

IGC researchers have developed a novel type of treatment involving metallic nano-bones which offers a way to activate chemotherapy drugs precisely at the tumour site sparing the rest of the body from the drugs' toxic effects: edin.ac/4khlnZU @cmvm-edinburghuni.bsky.social @jacs.acspublications.org

Three sets of paper are on laid out on a white background. Lines of text have been cut out of a white sheet of paper and have been photocopied.

A pair of hands is sticking blocks of text to a larger sheet. One of the hands is holding an orange pen.

Two people with long hair have their backs to us. They are looking at a collage which is in a large wooden frame and hung on a wall.

Three people are looking at something that is out of shot. They are laughing and smiling with each other.

@beverleyhood.bsky.social, artist and Reader in Technological Embodiment at ECA, is wrapping up a three-year research project, 'Surface Echoes', alongside Professor Sara Brown @uoe-igc.bsky.social, which aims to bring to life the everyday challenges and emotional impact of living with eczema.

Listen to Robb Hollis talking about this project on
BBC Radio Scotland this lunchtime (from 47:36 minutes): edin.ac/4lgwJya

£1.5m project will focus on aggressive ovarian cancer | Institute of Genetics and Cancer | Institute of Genetics and Cancer How cancer resists treatment is the focus of a £1.5million Cancer Research UK project to find new ways to tackle aggressive ovarian cancer.

How cancer resists treatment is the focus of a £1.5million @cancerresearchuk.org project led by Robb Hollis at #IGC and @cruk-si.bsky.social to find new ways to tackle aggressive ovarian cancer: edin.ac/3TDBENF
@cmvm-edinburghuni.bsky.social

Gene–Environment Interaction Affects Risk of Atopic Eczema: Population and In Vitro Studies Atopic eczema is a complex trait resulting from multiple genetic and environmental factors. This study investigated evidence for interaction between 24 established eczema genetic risk variants and 18...

New Publication:

Gene-Environment Interaction Affects Risk of Atopic Eczema: Population and In Vitro Studies

@uoe-igc.bsky.social

doi.org/10.1111/all....

Scale of how ME/CFS affects blood revealed People with ME/CFS have significant differences in their blood compared with healthy individuals a new study reveals, suggesting a path towards more reliable diagnosis of the long-term debilitating il...

People with ME/CFS have significant differences in their blood compared with healthy individuals a new study reveals: edin.ac/43RxKXx. Listen to @cgatist.bsky.social on BBC Radio 4's Today (from 1:22:45): lnkd.in/dRGhKttp
@cmvm-edinburghuni.bsky.social @avakhamseh.bsky.social

Blue square shapes with an image of an iPhone on a tripod to the right. White text over the top reads: "Open for submissions. Details in post or head to our website to enter". In the bottom left corner is the MRC Max Perutz Award 2025 logo.

This year's MRC Max Perutz Award is now open for submissions!

If you're an MRC PhD student, this is a great opportunity to build your sci-comms skills

And for the first time, enteries can be video or written 🎥✍️

Enter by 24 July 2025: www.ukri.org/what-we-do/d...