Julien Park

From lifesaving to life-improving: liver transplantation is reshaping how we treat inherited metabolic diseases.

This excellent review explores evolving indications, outcomes > 90%, and the precision-medicine future of metabolic transplant care.
onlinelibrary.wiley.com/doi/10.1002/...
#JIMD #IMD

This was associated with mitochondrial dysfunction and structural changes. Substitution of ascorbic acid led to decreased H2O2 levels and improved cell survival. This offers a potential therapeutic approach for this #raredisease

HO-1 deficiency is a devastating disorder of redox metabolism with few therapeutic options. In two independent models, we observed increased hydrogen peroxide and decreased ascorbic acid levels despite upregulation of SVCT2, a key ascorbic acid transporter.

Ascorbate mitigates oxidative stress and hemin cytotoxicity in heme oxygenase-1 deficiency Heme oxygenase-1 (HO-1) deficiency manifests with severe metabolic abnormalities, yet the underlying mechanisms remain incompletely understood. We investigated metabolic adaptations in HO-1 deficient ...

‼️New Publication‼️
So glad the first manuscript from my lab is finally out in @asbmbjournals.bsky.social
We studied redox changes in HO-1 deficiency and found substantial ascorbic acid depletion as a key pathogenetic feature.

tinyurl.com/3ujw5ryt

Efficient non-viral immune cell engineering using circular single-stranded DNA-mediated genomic integration - Nature Biotechnology CAR-T and NK cells engineered using a non-viral circular single-stranded DNA system show effective anti-tumor function.

This is pretty wild! Efficient non-viral genome editing of immune cells using circular single-stranded DNA. #science #hemesky 🩸🔬 www.nature.com/articles/s41...

Umeå is such a lovely place!

Finally said goodbye to #twitter The sky‘s looking blue and I‘m looking forward to our conversations here! #science #medicine

Inborn errors of metabolism in neonates and pediatrics on varying dialysis modalities: a systematic review and meta-analysis - Pediatric Nephrology Background Some inborn errors of metabolism (IEMs) resulting in aberrations to blood leucine and ammonia levels are commonly treated with kidney replacement therapy (KRT). Children with IEMs require p...

Inborn errors of metabolism in neonates and pediatrics on varying dialysis modalities: a systematic review and meta-analysis
link.springer.com/article/10.1...

Are you looking for a PhD position in #rarediseases ? Are you interested in #redox metabolism? Come and join us in Münster! jobs-sf.ukmuenster.de/job/Universi...

Happy to say that we‘re hiring! Come work with us as a PhD student working on inborn errors of redox metabolism #IEM #IMD. We‘re a young team focusing on this underserved group of #rarediseases.
If you need more info, please reach out to me! jobs-sf.ukmuenster.de/job/Universi...

A great honor to have been part of this team effort!

Very happy to do so! And great to connect on here

Hey, @kbv.de:
Aus eins mach zwei: Bei Intensivpflege für häusliche mobile Krankenpflege gab es bisher Formular 12,
jetzt dürfen wir Formulare 62b und 62c ausfüllen,
ist ja nur mal schnell doppelte Arbeit und doppeltes Fehlerpotential.

Bürokratie-Abbau für den A…!
#PraxisAlltag

Hi Bluesky! Looking to connect with anyone interested in #metabolism and #IEM and #pedsneuro. Trying to finalize my exit from the other app!

Who wants to be my colleague?

My department has an Assist Prof GI physiologist or microbiome position: jobs.rutgers.edu/postings/212...

Please share and repost!

Developmental & regenerative vascularization #zebrafish spinal cord
#SciArt

Contusion #SpinalCordInjury
90 dpi

Less dense More linear vessels
Barrier restored

#Pericyte proliferate in reparative #Angiogenesis
Ana Ribeiro, Leonor Saúde labs Open Biol 2023
royalsocietypublishing.org/doi/10.1098/...

I'm actually not sure how to effectively describe this. It's a model of inside a human but really distorted so the human looks like a slug? I don't know I'm not a doctor!

Body goals

Thanks a lot! Will keep these in mind.

Starting off #SSIEM2023 w/ a session re/ nutrition and dietetics!

On my way to Jerusalem for this year’s #SSIEM meeting. Looking forward to talks, meetings, and more all related to #metabolic disease!

Column: Scientists used to love Twitter. Thanks to Elon Musk, they're giving up on it Scientists came to see Twitter as an indispensable tool for communicating with each other and the public. As X, it's turned into a source of scientific misinformation and lies.

Column: Scientists used to love Twitter.

Thanks to Elon Musk, they’re giving up on it "found Twitter to be “a useful and at times almost essential tool for timely and important exchange of information.”

Sunday Funday!

🧪Using this meme to Introduce a new feed "Skyentific Jokes" for all scientists with a sense of humor.🌌 Your new go-to spot for the most cosmic science jokes

bsky.app/profile/did:...
Tags: #ScienceJokes #lab&fun

Feedback welcome to refine the feeds & tags.

#AcademicSky #PhDSky

Während meiner Zeit in Schweden im Winter Vitamin D. Ansonsten nichts.

@danirabaiotti.bsky.social I‘d love to join What‘s Science - could dou add me, please?

Hi Bluesky, I‘m Julien, a physician-scientist trying to work out the influence of redox dysbalance in inborn errors of metabolism. Hoping to connect w/ clinicians & basic scientists alike! Really hoping to see an even better science twitter here.