Savvides Lab

Now published @cp-cellreports.bsky.social! Antibody-mediated TGF-β1 activation for the treatment of diseases caused by deleterious T cell activity: www.cell.com/cell-reports...
Fantastic collaboration & massive effort from Sophie Lucas Lab @ de Duve Institute. #CryoEM with @savvideslab.bsky.social.

02.09.2025 11:25 — 👍 10    🔁 4    💬 2    📌 0

Finally out @natcomms.nature.com
"Single-domain antibodies directed against hemagglutinin and neuraminidase protect against influenza B viruses".
Great collab between @savvideslab.bsky.social (we performed #CryoEM) and Xavier Saelens Lab, spearheaded by Arne Matthys.

www.nature.com/articles/s41...

10.07.2025 08:45 — 👍 11    🔁 6    💬 1    📌 0

Reanalysis of cryo-EM data reveals ALK-cytokine assemblies with both 2:1 and 2:2 stoichiometries The mechanistic understanding of the complex between ALK kinase and its cytokine ligand ALKAL2 has been complicated by reports of diverse stoichiometries (2:1 vs 2:2). This study reanalyzes cryo-EM da...

Delighted to share our reanalysis of cryo-EM data in EMPIAR-10930, now at:

journals.plos.org/plosbiology/... ;

revealing the ALK-ALKAL2 assembly with 2:1 stoichiometry and resolving the conundrum introduced by the originally reported 2:2 complex. ALK/LTK-cytokine signalling getting clearer!

13.04.2025 19:04 — 👍 3    🔁 3    💬 1    📌 0