What Addiction Science Got Wrong About Dopamine, with Dr. David Nutt | Flourishing After Addiction #45
"It's inconceivable there can be just a single chemical that mediates all the effects of what addicted drugs have. That was so patently daft."
I spoke with Dr David Nutt of @Drug_Science
on one of addiction scienceβs biggest errors: dopamine as the whole story. βPatently daft,β he says.
(We also talk psychedelics, drug development, and circuit models)
Read more and listen here: carlerikfisher.substack.com/p/what-addic...
16.12.2025 16:54 β
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This book is out TODAY! I put my whole heart into it. You can buy it wherever you buy books. www.penguinrandomhouse.com/books/725681...
03.06.2025 12:41 β
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and now tagging @owenflanagan.bsky.social now, who i didn't realize was on bluesky!
22.04.2025 16:54 β
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Thanks Josh!
22.04.2025 16:53 β
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-what makes a behavioral addiction βreal?β
-the ethics of addiction, how to connect morality and virtue to addiction recovery without reinforcing stigma.
And throughout, Owen shares about his own recovery process, including how it evolved over time and what heβs working on today.
22.04.2025 11:53 β
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We talk about:
-the spectrum of "powerlessness" in addiction and the finer points of self-control
-problems with traditional explanations of willpower
-critiques of the usual stories about dopamineβs role in addiction
-behavioral additions like sex, shopping, and video games
22.04.2025 11:53 β
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He brings that deep knowledge to bear on addiction to challenge oversimplified addiction narratives and offers what he calls an "ecumenical" approachβarguing that substance addictions are far more heterogeneous than we often recognize, with diverse causes, neural profiles, and lived experiences.
22.04.2025 11:53 β
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The book combines personal reflections with philosophical expertise to propose a new, integrated model for understanding substance addiction. Owen, Professor Emeritus at Duke, is internationally acclaimed for his work in cognitive science, ethics and the philosophy of psychology and neuroscience.
22.04.2025 11:53 β
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I posted a comment about the mutual aid comparisons here
25.03.2025 22:09 β
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Ooooh fascinating I look forward to reading this
22.03.2025 13:42 β
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This is why I was glad to see the post by Freddie, from someone with lived experience of what it's actually like to be manic/psychotic. I also wonder if Delano takes the subway.
19.03.2025 08:33 β
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I don't know what to call it either! But I do know that even in coaching, usually quite unregulated and to my mind less formal than peer support, orgs still have ethics guidelines about seeking outside help when a client is a danger to self or others.
18.03.2025 23:55 β
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I'd be interested in more on that concept. For example it seems like there is an important distinction between assessing 1. Whether gaming contributes to life domains (effect) versus 2. The intention with which one comes to a gaming session (initial motivation?)
14.03.2025 11:41 β
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Well done! To me, "gaming life fit" is the most interesting element here. I understand from the paper that you are still developing this measure. Conceptually it seems like rich and complicated ground to assess the subjective alignment of gaming with valued life domains.
14.03.2025 11:41 β
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It's very meaningful to hear from you, thanks for sharing. And glad you're ok these days.
09.02.2025 12:31 β
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relevant front page of FT today about the Trump memecoin today, which I discuss in my gambling essay
08.02.2025 16:34 β
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Thanks!
08.02.2025 16:18 β
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There are lessons here for how we protect ourselves as individuals, guide our children through a world increasingly littered with gambling dynamics, and build commonsense regulations that acknowledge gambling as a public health issue.
08.02.2025 15:57 β
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I describe how gamblingβs harms extend far beyond what we commonly understand, and how the gambling boom (a $150 billion industry!) reveals truths about the addiction in all of us. Modern tech has also transformed a simple wager into a highly targeted, always-on stream of micro-bets.
08.02.2025 15:57 β
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Opinion | The Price We Pay Betting on Sports
I have a new essay out in The New York Times today: "What Sports Betting Reveals About Addiction." I challenge some assumptions about addiction through the lens of Americaβs sports betting explosion, just in time for Super Bowl Sunday.
www.nytimes.com/2025/02/08/o...
08.02.2025 15:57 β
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Welcome!
06.02.2025 20:51 β
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Keith Humphreys and John Kelly setting the record straight
30.01.2025 20:36 β
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The Society for the Study of Addiction have just joined Bluesky. Please give them a follow! @ssa-addiction.bsky.social
29.01.2025 15:32 β
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I think Ian McGilchrist would agree, though he puts it all in left/right brain terms
27.01.2025 18:28 β
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