22nd of December and I already got my first Christmas present 🎁

My first paper has been published in NAR as a Breakthrough article and I’m beyond excited ✨

A big thanks to everyone involved in this project, especially Jens Wöhnert and Hermann Schindelin @en-hxnu-enment.bsky.social !

⭐NAR Breakthrough! ⭐
🧬 A synthetic RNA forms a #G-quadruplex without a G-rich sequence, using a complex 3D fold and GTP as a ligand. This suggests G-quadruplexes may be far more widespread in biologically important RNAs. Read more: doi.org/10.1093/nar/...

#NARBreaktrhough #RNA #StructuralBiology

Variant mutation in SARS-CoV-2 nucleocapsid enhances viral infection via altered genomic encapsidation bioRxiv - the preprint server for biology, operated by Cold Spring Harbor Laboratory, a research and educational institution

1/n Very excited to share my lab's latest manuscript, 3 years after I started my independent group! This was a fantastic collaboration with Bryan Johnson and @themenacherylab.bsky.social , led by joint 1st authors Hannah Kubinski and Hannah Despres in my lab www.biorxiv.org/content/10.1...

biorxiv.org/content/10.1... Here’s a paper that was many years in the making. The idea that the climate can affect the thermodynamic mechanism of binding due to the temperature dependence of the entropy term is interesting- we see gradual shift in binding mode along evo trajectory…

Pre-print is up! SARS-2 produces a truncated N protein to antagonize multiple antiviral pathways. A very collaborative project in the @corcoranlab.bsky.social with @nogasharlin.bsky.social, Danyel Evseev, and Max Bui-Marinos, and of course the boss Jenn Corcoran

www.biorxiv.org/content/10.1...

Congratulations to our SPC facility user, Karthi Dhamotharan and the Schlundt Lab, for such an achievement on SARS-CoV-2 nucleocapsid protein and RNA binding 🦠🧬

Well done ! 👍

@embl.org @cssbhamburg.bsky.social

A core network in the SARS-CoV-2 nucleocapsid NTD mediates structural integrity and selective RNA-binding - Nature Communications The authors use solution-state NMR and X-ray crystallography to study mutations in the SARS-CoV-2 Nucleocapsid NTD, uncovering a network essential for protein integrity and the selectively of RNA bind...

Our work on how a conserved core network in the SARS-CoV-2 nucleocapsid NTD affects stability, RNA-binding affinity, and selectivity of the domain is now online.
www.nature.com/articles/s41...

Collage of SARS-CoV-2 structures released in the PDB this year

19 new SARS-CoV-2 structures this week, 696 this year (shown), for 4606 total available in the PDB.
Explore them all at rcsb.org/covid19