Karsten Suhre

A genome-wide association study of mass spectrometry proteomics using a nanoparticle enrichment platform - Nature Genetics Genome-wide association analyses of blood plasma samples using a mass spectrometry-based platform illustrate the complementarity of different proteomics approaches for identifying protein quantitative...

Come and join me for a GenomeWeb webinar supported by Seer on

"Unbiased Plasma Proteomics Expands GWAS Insights"

Wednesday, March 11, 2026

12:00 PM Eastern Daylight Time

Register here:

event.on24.com/wcc/r/521498...

More details:
www.genomeweb.com/events

Identification of Protein Signatures Reflecting Latent Variation in Aptamer-Based Affinity Proteomics Accurate quantification of circulating proteins is critical for assessing biological variation and integrating proteomics with other omics to understand biological processes and disease mechanisms. Pr...

Using @somalogic.bsky.social affinity #proteomics data from three cohorts and #pQTL association strength as a readout we identify protein signatures reflecting latent variation in aptamer-based affinity proteomics.

Learn how HSP90 can act as a proxy for cell-lysis.

pubs.acs.org/doi/full/10....

Very interesting approach… how about extending this to data that also has ion mobility data?

Quantifying the ∼75–95% of Peptides in DIA-MS Data Sets that Were Not Previously Quantified We have developed a novel algorithm termed GoldenHaystack (GH) that was designed for enhanced peptide quantification of data-independent acquisition liquid-mass spectrometry (DIA-LC-MS) data files reg...

Quantifying the ∼75–95% of Peptides in DIA-MS Data Sets that Were Not Previously Quantified #JProteomeRes pubs.acs.org/doi/10.1021/...

Our paper is now available in the print edition of Proteomics:

"Comparative Analysis Between Olink-PEA and Alamar-NULISA Proteomic Technologies Applied to a Critically Ill COVID-19 Cohort"

dx.doi.org/10.1002/pmic...

A study on 1.7 million people in Hong Kong shows superior hybrid immunity to Covid in people who got vaccinated before infection vs. people who got infected first. "Our findings are a direct rebuttal to arguments for natural immunity," the authors write. doi.org/10.1016/j.va...

Howto 3D-print proteins and molecules from the PDB by KS MakerWorld: Download Free 3D Models How to print 3D protein and molecular structures - from virtual to physicalThis is a 3D print of an antibody bound to a protein, i.e. PDGF-B blocking antibody bound to PDGF-BB. Blue and red are two su...

Here a tutorial on how to easily 3D-print proteins and other macro-molecules:

makerworld.com/en/models/96...

WCM-Q study probes use of nanoparticles for human protein analysis Researchers at Weill Cornell Medicine-Qatar (WCM-Q) have published a study demonstrating the use of an advanced nanoparticle-based tool for analyzing human proteins in order to discover both their fun...

qatar-weill.cornell.edu/media-center...

Faecal metabolites as a readout of habitual diet capture dietary interactions with the gut microbiome - Nature Communications Here, by integrating faecal metabolomics, metagenomics, and habitual dietary data of two large human cohorts, the authors show that faecal metabolites reflect diet and gut microbiome interactions, pre...

Faecal metabolites as a readout of habitual diet capture dietary interactions with the gut microbiome.

By integrating faecal metabolomics, metagenomics, and dietary data Falchi et al. show that faecal metabolites capture mediations between diet and the gut microbiome

www.nature.com/articles/s41...

A genome-wide association study of mass spectrometry proteomics using a nanoparticle enrichment platform - Nature Genetics Genome-wide association analyses of blood plasma samples using a mass spectrometry-based platform illustrate the complementarity of different proteomics approaches for identifying protein quantitative...

Read our latest paper just published in Nature Genetics :

A genome-wide association study of mass spectrometry proteomics using a nanoparticle enrichment platform

www.nature.com/articles/s41...

Honestly - these days the most interesting part is often the exchange with the reviewers - great idea to make these public: our paper has 67 pages, they can be found here: static-content.springer.com/esm/art%3A10...

I agree, the Somalogic VTN pQTL is certainly such a case.

Suspense !

Our new #GWAS with MS #proteomics paper has been scheduled for publication in Nature Genetics on 27 November 2025 at 10:00 (London time) and will be available at the following URL: www.nature.com/articles/s41...

Genomics of drug target prioritization for complex diseases - Nature Reviews Genetics In this Review, Chen et al. discuss how the advancement and integration of large-scale genetic resources, multi-omics data and sophisticated computational tools are improving drug development pipeline...

Genomics of drug target prioritization for complex diseases - a Nature Reviews Genetics review:

www.nature.com/articles/s41...

Heterogeneity of Diabetes - NIDDK This Report outlines research Recommendations from the NIDDK’s Working Group of Council on Heterogeneity of Diabetes.

Recommendations from the NIDDK’s Working Group of Council on Heterogeneity of Diabetes:

www.niddk.nih.gov/about-niddk/...

Pharma companies take note - human knockouts in bottleneck and consanguineous populations are up and coming.

Plasma Metabolic Outliers Identified in #Estonian Human Knockouts: www.mdpi.com/2218-1989/15...

citing our #Qatar study with @metabolon.bsky.social data:

www.cell.com/cell-genomic...

First Shape Found That Can’t Pass Through Itself | Quanta Magazine After more than three centuries, a geometry problem that originated with a royal bet has been solved.

Nic - look at this:

www.quantamagazine.org/first-shape-...

How did you mathematically generate these?

“Our study [in Cancer Discovery] suggests a new therapeutic approach to block metastasis before it starts, and help patients overcome triple negative breast cancer,” said Dr. Vivek Mittal (@MittalLab) from the Meyer Cancer Center and there EIPM.

news.weill.cornell.edu/news/2025/10...

🔬Inside the Core Lab: Driving Discovery in #Proteomics
Explore one of the key labs supporting cutting-edge proteomics research in Qatar. Meet the team and discover the advanced technologies driving biomedical breakthroughs.

Featured in the lead-up to #QPC2025 — where innovation meets collaboration.

Heterogeneity of Diabetes - NIDDK This Report outlines research Recommendations from the NIDDK’s Working Group of Council on Heterogeneity of Diabetes.

This Report outlines research Recommendations from the NIDDK’s Working Group of Council on Heterogeneity of #Diabetes, a result of tremendous effort and significant contributions from global investigators and #NIDDK staff.

www.niddk.nih.gov/about-niddk/...

Current landscape of plasma proteomics from technical innovations to biological insights and biomarker discovery - Communications Chemistry Plasma proteome profiling has surged as a promising avenue for biomarker discovery, yet comprehensive platform comparisons remain scarce. Here, the authors evaluate eight proteomics platforms, revealing key differences and complementary strengths, providing crucial insights for researchers into coverage trade-offs and implicating biomarker discovery and clinical applications.

A pretty comprehensive comparison of most actual #proteomics platforms:

Current landscape of plasma proteomics from technical innovations to biological insights and biomarker discovery

www.nature.com/articles/s42...

October's #LipidoftheMonth is a sterol that might be causing quite a buzz soon.
www.lipidmaps.org/updates/lipi...

Great initiative… Unfortunately I can already see all kinds of IRB and MTA paperwork around sharing and shipping these samples around. Have seen too much of this lately. Feels like the central aim of doing research these days is being compliant. But maybe I am overly pessimistic.

A standardized framework for circulating blood proteomics Nature Genetics - The field of blood proteomics faces an upsurge of data with the challenge of cross-study comparisons. This Perspective offers an in-depth analysis and proposes reference materials...

"A standardized framework for circulating
blood proteomics" ... it summarizes many of the challenges encountered in the field, although I miss any reference to genetic aspects of blood proteomics, i.e. cis-pQTLs to confirm target specificity and epitope effects

www.nature.com/articles/s41...

I have always been a proponent of hypothesis-free testing of metabolite rations: This paper is just great in how it takes it to the next level:

Untargeted pixel-by- pixel metabolite ratio imaging as a novel tool for biomedical discovery in mass spectrometry imaging

elifesciences.org/articles/96892

Qatar Investment Authority invests in quantum computing firm PsiQuantum The Qatari sovereign wealth fund adds yet another company to its set of “forward-looking, tech-led” investments. The Qatar Investment Authority (QIA) has invested in a quantum computing company seekin...

dohanews.co/qatar-invest...

This could be interesting…

Years ago I asked on Twitter why my heart rate would continue to climb even after I fixed the speed and incline on my treadmill. At the time, no one on Twitter could give me a satisfactory answer.
But now GPT4o was able to answer it and suggested approaches to quantify the phenomenon.

[ASAP] Understanding Data Analysis Steps in Mass-Spectrometry-Based Proteomics Is Key to Transparent Reporting Journal of Proteome ResearchDOI: 10.1021/acs.jproteome.5c00287

(J Proteom Res) [ASAP] Understanding Data Analysis Steps in Mass-Spectrometry-Based Proteomics Is Key to Transparent Reporting: Journal of Proteome ResearchDOI: 10.1021/acs.jproteome.5c00287 #MassSpecRSS

A nanobody specific to prefusion glycoprotein B neutralizes HSV-1 and HSV-2 - Nature A neutralizing nanobody specific to the prefusion conformation of herpes simplex virus glycoprotein B has cross-species activity and offers insights into virus neutralization, possible immunogens and ...

Prefusion gB of HSV bound with a neutralizing nanobody www.nature.com/articles/s41...