Chris van der Gast

Interrogating microbiomes and metabolomes during P. aeruginosa infiltration and colonisation in CF respiratory tract infection at Manchester Metropolitan University on FindAPhD.com PhD Project - Interrogating microbiomes and metabolomes during P. aeruginosa infiltration and colonisation in CF respiratory tract infection at Manchester Metropolitan University, listed on FindAPhD.c...

PhD studentship @manmetuni.bsky.social applications now open! Interested in the mechanisms of microbial invasion in respiratory disease? This @cysticfibrosis.org.uk match funded PhD might be for you! www.findaphd.com/phds/project...

Resistance, resilience, and redundancy in the human gut microbiome at Newcastle University on FindAPhD.com PhD Project - Resistance, resilience, and redundancy in the human gut microbiome at Newcastle University, listed on FindAPhD.com

Project details can be found here: www.findaphd.com/phds/project...
The deadline for applications is Friday 27th February 2026

How to apply and application links are here (not via findaphd): www.needl.org.uk/apply/

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I have an open BBSRC PhD position in my lab at @northumbriauni.bsky.social to start Oct 2026

This exciting project will focus on the Resistance, resilience, & redundancy in the human gut microbiome

This is part in collaboration with the fantastic @stewartlab.bsky.social

Project details ⤵️

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Remodelling of cystic fibrosis respiratory microbiota in response to extended Elexacaftor/Tezacaftor/Ivacaftor therapy Background: Cystic fibrosis (CF) has profoundly changed since the introduction of CF Transmembrane Conductance Regulator modulator therapies (CFTRmt), a class of medications that improve function of t...

Excited to share our new work comparing the impact of long-term CFTR modulator therapy on #CF lung pathogens & respiratory microbiome within a large, multi-centre & multi-national cohort of adults living with #cysticfibrosis

www.medrxiv.org/content/10.1...

Investigating microbiota differences across chronic pancreatitis, influenced by lifestyle and genetic determinants - BMC Gastroenterology Chronic pancreatitis (CP) is a multifaceted and irreversible inflammatory condition that impacts both endocrine and exocrine pancreatic functions. Whilst there is evidence of a general intestinal micr...

Our new paper out on influence of chronic pancreatitis on the gut microbiome. What makes this more special is it is Ryan Marsh’s 1st as corresponding author.

doi.org/10.1186/s128...

The above is either the journal/publisher’s system issue or it’s a handling editor just not engaging their brain. Either way it is a very poor approach to peer review that clearly doesn’t value the reviewer. And if that is the case…

Got an invite to review a paper on Friday night from a well-known clinical journal. Followed by an abrupt & demanding reminder early Sunday morning

I wonder why it is increasingly difficult to get willing quality reviewers these days?🤷‍♂️

Unsurprisingly I declined the offer to review

GRAMPUS-CF | Discover Gut Insights Today Join the GRAMPUS-CF study to explore gut symptoms in cystic fibrosis and help develop personalized treatments. Enroll online or via CF centers.

Great to be in Queen's Univerity Belfast for the GRAMPUS-CF conference

This @cysticfibrosis.org.uk funded Strategic Research Centre is exploring ‘clusters’ of gut symptoms in #CysticFibrosis to see if they have common causes

More details on GRAMPUS #CF ⬇️ www.grampus-cf.org

Nontuberculous mycobacteria remodel lung microbiota in cystic fibrosis-associated respiratory infections | Microbiology Spectrum The influence of NTM infection in pwCF is still debated, and the extent of their contribution to mortality and morbidity is still questioned. Findings in this study highlight a link between the presen...

Our new paper out in Microbiology Spectrum:

Nontuberculous mycobacteria remodel lung microbiota in #cysticfibrosis associated respiratory infections

Driven by @dwrivett.bsky.social and Michelle Hardman.

From Michelle’s @cysticfibrosis.org.uk funded PhD work

#CF

doi.org/10.1128/spec...

Species turnover within cystic fibrosis lung microbiota is indicative of acute pulmonary exacerbation onset - Microbiome Background Acute pulmonary exacerbations (PEx) are associated with increased morbidity and earlier mortality for people living with cystic fibrosis (pwCF). The most common causes of PEx in CF are by b...

Our new paper out now in Microbiome: Species turnover within #cysticfibrosis lung microbiota is indicative of acute pulmonary exacerbation onset

doi.org/10.1186/s401...

#CF #microbiomeecology #microbiome

Our very own @hgavillet.bsky.social giving her talk today at #ECFS2025 in Milan on the impact of #kaftrio CFTR modulator therapy on the #CysticFibrosis lung microbiome

Our KAFPATH-CF study is a multi-national (UK, USA, & Canada) multi-centre long-term longitudinal study of adults with #CF

Our very own Ryan Marsh presenting his #CysticFibrosis gut microbiome & metabolomics data at the #ECFS2025 meeting in Milan

This is part of the wider @cysticfibrosis.org.uk funded GRAMPUS-CF strategic research centre

👀 here for more details www.grampus-cf.org

Personalized inhaled bacteriophage therapy for treatment of multidrug-resistant Pseudomonas aeruginosa in cystic fibrosis Nature Medicine - A novel personalized phage therapy strategy that selects phages for a predicted evolutionary trade-off may represent a viable alternative approach for the treatment of...

Fascinating and important study. May well be transformative in treatment of stubborn chronic lung infections such as by Pseudomonas aeruginosa in #cysticfibrosis and beyond

rdcu.be/ekdWf

Ryan Marsh from my group giving a great talk on our initial #CysticFibrosis gut microbiome findings from our GRAMPUS-CF strategic research centre @ the #ECFS Basic Science meeting in Italy

Final day of the European Young Investigators Meeting #EYIM for #cysticfibrosis in Paris

Delighted to be supporting as a ‘senior’ scientist

The #EYIM2025 presentations have been outstanding

The talent displayed at this meeting bodes well for future of #CF research

Helen giving her Rising Star talk @ the #RTI2025 meeting in Glasgow ⭐️

@hgavillet.bsky.social #CF #CysticFibrosis

What a a great place to meet & talk on new #cysticfibrosis respiratory & gut studies with the lovely folk from Manchester Paediatric #CF centre

Feeling genuinely inspired

Whitworth Art Gallery - Manchester

Helen a PDRA in my lab @northumbriauni.bsky.social has been recognised with the Rising Star award @ the upcoming Respiratory Infections Forum #RTI2025.

Well done Helen, what a great recognition!

rti-forum.org/2025/
@lenagroup4resp.bsky.social

Ah, the glamour of international travel. This red eye flight is so early I had to get up half an hour before I went to bed.

…. in Dartmouth 😂

That paper would be old enough to buy me and you a beer 🍺🍺😄

Microbiome ecology approaches reveal bacterial interactions underpin worse lung function in #CysticFibrosis

#CF Lung infections are not caused by 1 pathogen in isolation but instead by interplay of complex lung microbiota of many different microbes interacting with each other & the lung environment

GI pathophysiology and Gut microbiome. Survey closed hence posting.

Thanks Fabrice!

Bacterial interactions underpin worsening lung function in cystic fibrosis-associated infections | mBio Research studies have repeatedly demonstrated that chronic lung infection in cystic fibrosis is polymicrobial and consequently does not adhere to the single microbe-based Koch’s postulates. Despite th...

Fantastic to see our latest paper now published in mBio on how species interactions impact #cysticfibrosis respiratory infections ⤵️

#microbiomeecology #cf

Lovely way to finish the week

doi.org/10.1128/mbio...

I think it is @dralirobb.bsky.social. But I’ve been here like two minutes and am also trying to figure out what works 😄

After editing, this very short letter to New Scientist is even shorter now. But I think it gets the point across! @faecalmatters.bsky.social

That would be great. The other place is dying on its backside now

Impact of extended Elexacaftor/Tezacaftor/Ivacaftor therapy on the gut microbiome in cystic fibrosis There is a paucity of knowledge on the longer-term effects of CF transmembrane conductance regulator (CFTR) modulator therapies upon the gut microbiom…

Our latest paper now published in Journal of #cysticfibrosis

Impact of extended Kaftrio therapy on the gut #microbiome in #cf

Great work from Ryan Marsh (not yet in this place)

sciencedirect.com/science/arti...