IgG4-related disease and other fibro-inflammatory conditions
www.nature.com/articles/s41...
IgG4-related disease and other fibro-inflammatory conditions
www.nature.com/articles/s41...
Mechanisms of prothrombotic cell activation by anti-β2GPI IgG. The diagram highlights the receptors most commonly linked to cell activation by β2GPI/anti-β2GPI IgG surface complexes, as well as some effectors known to be downstream of that activation. β2GPI: beta-2 glycoprotein I, LRP: low-density lipoprotein receptor-related protein, ROS: reactive oxygen species, TF: tissue factor, TLR: Toll-like receptor, and VWF, von Willebrand factor
Mechanisms of prothrombotic cell activation by anti-β2GPI IgG. The diagram highlights the receptors most commonly linked to cell activation by β2GPI/anti-β2GPI IgG surface complexes, as well as some effectors known to be downstream of that activation
#Rheumsky #Immunosky
Non-Criteria Obstetric Antiphospholipid Syndrome: Myth or Reality?
NC-OAPS: heterogeneous condition and ambiguously described in literature
#APS #OAPS #Pregnancy #autoimmune
Today is International Vasculitis Day!
Take a look at some of our articles on vasculitis:
Evidence-Based Guideline for the diagnosis and management of eosinophilic granulomatosis with polyangiitis bit.ly/4kjASRj
The new look of classification criteria for systemic vasculitis bit.ly/3GXJLlc
Behçet syndrome
🩸systemic #vasculitis, affects vessels of all calibers
🩺 venous #thrombosis with arterial #aneurysms, inflammatory parenchymal brain involvement, posterior #uveitis with retinal vasculitis, bipolar #ulcers and erythema nodosum
⁉️ controversy: pathergy test or HLA-B*51 in diagnosis
🧬Monogenic vasculitis: DADA2, HA20, SAVI, COPA, LAVLI, VEXAS—rare but real
🧠DADA2: Livedo racemosa, strokes, skin necrosis
🧠 HA20: Behçet-like—ulcers, uveitis, venous thrombosis.
🧠SAVI: Skin ulcers, nasal perforation
🧠COPA: Skin/intestinal vasculitis, ILD
🧠VEXAS
Arterial and venous thrombosis in systemic and monogenic vasculitis
⚠️ Be aware for early diagnosis‼️
🧬 Genetic testing vital—variable penetrance! Early strokes hint at diagnosis.
#vasculitis #thrombosis #monogenic #stroke #skin
www.nature.com/articles/s41...
🚨2024 American College of Rheumatology (ACR)
Guideline for the Screening, Treatment, and
Management of Lupus Nephritis
#Lupus #Nephritis #Guideline #Treatment #SLE
assets.contentstack.io/v3/assets/bl...
Consensus nomenclature and abbreviation for anti-synthetase syndrome: an IMACS project
🚩lack of uniform terminology and abbreviations = challenges in research and clinical practice
🏳️anti-synthetase syndrome and ASyS should be adopted as the standard nomenclature
academic.oup.com/rheumatology...
Remnant cholesterol predicts risk
of recurrent thrombosis beyond LDL‑cholesterol
in patients with antiphospholipid syndrome
🟠RC ➡️ increased risk of trombosis
🟠RC marker for thrombotic risk❓
🟠potential target
for therapeutic intervention.
bmcmedicine.biomedcentral.com/counter/pdf/...
EULAR recommendations for use of antirheumatic
drugs in reproduction, pregnancy, and lactation: 2024
update
🤰🏽👩🏽🍼
ard.eular.org/action/showP...
Consensus Recommendations for the Management of Neurosarcoidosis
www.neurology.org/doi/10.1212/...
Recommendations for the use of DMARDs in pregnancy and reproductive health for patients with rheumatic disease: A scoping review
acrjournals.onlinelibrary.wiley.com/doi/10.1002/...
To B or Not to B — the Role of B-Cell Depletion in Lupus Nephritis
www.nejm.org/doi/full/10....
IL-10 in Systemic Lupus Erythematosus: Balancing Immunoregulation and Autoimmunity
🔑involved in inflammatory and immune processes in SLE.
🔹IL-10 did not correlate with disease activity, organ in-
volvement, or treatment response.
www.mdpi.com/1422-0067/26...
A proposed clinical tool to identify high-risk patients for #monogenic #lupus: a pilot study
💡<5 years
💡cosanguinity
💡Family #SLE
💡elevated ANA
💡pancytopenia
💡cutaneus lesions
💡Low C1q
💡Recurrent infections
💡Failure to thrive
www.clinexprheumatol.org/abstract.asp...
Therapeutic approaches for
#SAPHO syndrome from the
perspective of pathogenesis:
a review of the literature
🔸Autoinflammatory
🔸cutaneous & osteoarticular
🔹ATB, tonsillectomy
🔹DMARDs
🔹Bisphosphonates
www.frontiersin.org/journals/imm...
British Association of Dermatologists and British Society for Rheumatology living guideline for managing people with Behçets 2024
👇🏼👀
academic.oup.com/bjd/article/...
Prognostic insights from symptom clustering analysis in systemic lupus erythematosus
1️⃣ Articular/mucocutaneous ➡️better survival
2️⃣Severe phenotype with renal involvement ➡️ poor prognosis
3️⃣Mixed connective tissue disease-like features with anti-U1-RNP antibodies
rmdopen.bmj.com/content/11/2...
Urine Protein Tests in Systemic Lupus Erythematosus:
What Do They Mean?
#SLE #Lupus #LN
www.jrheum.org/content/jrhe...
Autoinflammatory Diseases: A Revision
www.jrheum.org/content/51/9...
Antiphospholipid syndrome in pregnancy: a comprehensive literature review
🤍
bmcpregnancychildbirth.biomedcentral.com/articles/10....
A Phase 3 Trial of Upadacitinib for Giant-Cell Arteritis
📌In patients with giant-cell arteritis, upadacitinib at a dose of 15 mg — but not 7.5 mg — with a 26-week glucocorticoid taper showed efficacy superior to that of placebo with a 52-week glucocorticoid taper
www.nejm.org/doi/full/10....
Comparative Efficacy of Immunosuppressive Therapies in the Treatment of Diffuse Cutaneous Systemic Sclerosis
🔸MMF in dcSSc and show benefit especially in early-stage disease. 🔸High-risk ab for lung fibrosis ➡️ suitable for MMF treatment.
acrjournals.onlinelibrary.wiley.com/doi/full/10....
Thoracic Manifestations of ANCA-associated Vasculitis: Review of the 2022 American College of Rheumatology–European Alliance of Associations of Rheumatology Classification Criteria
#ANCA #Vasculitis
pubs.rsna.org/doi/10.1148/...
2024 American College of Rheumatology (ACR) Guideline for the Screening, Treatment, and Management of Lupus Nephritis
acrjournals.onlinelibrary.wiley.com/doi/10.1002/...
Familial Mediterranean Fever; Recent Advances, Future Prospectives
🤩 Wonderful review of #FMF, it’s a must!
www.mdpi.com/2075-4418/15...
Systemic lupus erythematosus: one year in review 2025
🔸New insights into immune dysregulation
🔸Emerging treatments: Promising therapies
🔸Real-world impact: Anifrolumab and belimumab
www.clinexprheumatol.org/article.asp?...
Pentose phosphate pathway metabolite restores T cell balance in SLE
#SLE #LUPUS
www.nature.com/articles/s41...
Low aCL levels are associated with:
📍IgG aCL: higher incidence of pregnancy-related complications
❓Should Screening for aCL in the first trimester be implemented into routine clinical practice?