Zachary L. Smith, DO, MSc. (Oxon)'s Avatar

Zachary L. Smith, DO, MSc. (Oxon)

@zachsmithgi.bsky.social

Academic Gastroenterologist and Clinical Trialist

171 Followers  |  147 Following  |  10 Posts  |  Joined: 15.01.2025
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Posts by Zachary L. Smith, DO, MSc. (Oxon) (@zachsmithgi.bsky.social)

This clip from @profgalloway.com resonates with something I recently wrote about rejection in academic medicine. substack.com/@trialisttri...

24.02.2026 11:52 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0

Circling back to this a year later…
@ebtapper.bsky.social I would argue that the data itself is good but it MUST be handled at the IPD level by statistical experts. I think >95% of studies using aggregate data and the TriNetX UI analytics are not believable. www.cghjournal.org/article/S154...

20.02.2026 22:47 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
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We Regret to Inform You... Lessons from the rejection pile

open.substack.com/pub/trialist...

20.02.2026 04:02 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
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The Opportunity Cost of Status Quo Science Why innovation in trial design matters for patients, clinicians, and the future of medicine

open.substack.com/pub/trialist...

05.10.2025 17:23 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
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Content being content: Tuning out the unrest of others TTT goes a bit sentimental about career mobility, institutional fit, and the quiet power of support

open.substack.com/pub/trialist...

24.07.2025 19:23 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
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Time to RESUME: Rekindling Trialist Tribulations Charting a new course for RESUME after PCORIβ€”and amid the current political climate

substack.com/@trialisttri...

24.07.2025 01:08 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0

β€œInstitutions don’t love you back” is a favorite of mine & one highlighted by Scott Galloway. I don’t have loyalty to my institution because it is an inanimate object. It can’t love me back. I have loyalty to people.

07.02.2025 05:05 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
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Researchers, trialists, and all, I've started a Substack publication called The Trialist Tribulations. The first edition drops tonight. I'd be grateful if you gave it a read. Please consider subscribing if you don't hate it. 🀞
#MedSky #AcademicSky #GISky open.substack.com/pub/trialist...

06.02.2025 02:02 β€” πŸ‘ 2    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0

Won’t be easy to tell a coffee lover they have a 50% chance of being randomized to no coffee for a number of years! That trial is gonna fail to meet its enrollment goal.

31.01.2025 21:24 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 2    πŸ“Œ 0
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Coming soon: The Trialist Tribulations The Trialist Tribulations is a new publication consisting of "weekly musings from the world of academic medicine."

open.substack.com/pub/trialist...

31.01.2025 04:40 β€” πŸ‘ 3    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0